Article
Endocrinology & Metabolism
I Converti, A. Palermo, A. Mancini, M. E. Maggiore, G. M. Tartaglia, E. Ferrara, F. Lorusso, A. Scarano, I. R. Bordea, C. Sforza, C. Maspero, M. Farronato, M. G. Cagetti, A. Patano, S. Ceci, A. Corriero, D. Hazballa, A. Gnoni, E. Gentile, A. Semjonova, K. Ferati, A. Bexheti-Ferati, M. F. Coscia, R. Del Prete, E. Xhajanka, At Pustina-Krasniqi, G. Malcangi
Summary: This study aimed to investigate the effects of intensive periodontal treatment on the salivary levels of oxidative stress in patients with moderate periodontitis. The results showed that intensive periodontal treatment significantly decreased the levels of nitric oxide and malondialdehyde, and increased the concentration of glutathione in salivary samples.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Iwona Olszewska-Czyz, Kristina Kralik, Marin Tota, Jelena Prpic
Summary: Periodontitis is a common oral disease caused by bacteria and immune responses. This study shows that the addition of hyaluronic acid to non-surgical periodontal therapy can increase antioxidants in saliva and improve the prognosis and results of periodontal therapy. Additionally, the levels of gingival inflammation and periodontal destruction are closely related to these markers.
Article
Dentistry, Oral Surgery & Medicine
Aysegul Sari, Vedat Davutoglu, Emrullah Bozkurt, Ibrahim Levent Taner, Kamile Erciyas
Summary: The study showed that periodontitis and atherosclerosis may increase systemic oxidative stress, with a more pronounced effect when they coexist. Periodontitis may be associated with increased systemic TOS and OSI values in patients with atherosclerosis.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Tanja Veljovic, Ivana Gusic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Ana Tadic, Snezana Brkic
Summary: Oxidative stress may serve as a link between diabetes mellitus and periodontitis. In this study, the salivary lipid peroxidation (LP) in periodontitis patients with and without type 2 diabetes was evaluated. The results showed that the improvement in clinical periodontal status following nonsurgical periodontal therapy is accompanied by a significant decrease in salivary LP in diabetes mellitus type 2 (DM2) patients, suggesting that periodontitis is the primary driver of the elevated salivary LP in this group.
Review
Health Care Sciences & Services
Gaia Viglianisi, Gianluca Martino Tartaglia, Simona Santonocito, Mariacristina Amato, Alessandro Polizzi, Marco Mascitti, Gaetano Isola
Summary: Periodontitis is a complex oral disease that causes destruction of periodontal tissues and tooth loss. The effective treatment of periodontitis and the affected periodontal tissues remain challenging. This study aims to explore new therapeutic strategies for personalized approaches in periodontitis through the use of oxidative stress biomarkers. ROS metabolisms and their role in periodontitis have been recently studied. The measurement of reactive oxygen metabolites (ROMs) in plasma has been used as an indicator of oxidizing capacity and the involvement of sulfur amino acid homocysteine (Hcy) in promoting free radical production has been observed. Thioredoxin (TRX) and peroxiredoxin (PRX) systems regulate ROS and antioxidant enzyme activities to counteract free radicals. The TRX system transduces redox signals for this purpose.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Tanja Veljovic, Milanko Djuric, Jelena Mirnic, Ivana Gusic, Aleksandra Maletin, Stojan Ivic, Marija Stojilkovic, Snezana Brkic
Summary: This study compared the SOD concentrations in saliva and plasma between patients with periodontitis and those with healthy periodontium, and evaluated the effect of nonsurgical periodontal therapy on salivary and plasma SOD in periodontitis patients. The results showed that SOD levels in the saliva of periodontitis patients were significantly higher compared to healthy individuals, and periodontal therapy led to a significant decrease in salivary SOD. These findings suggest that elevated salivary SOD may play a role in tissue protection against oxidative stress in periodontal disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Prima Buranasin, Hiromi Kominato, Koji Mizutani, Risako Mikami, Natsumi Saito, Kohei Takeda, Takanori Iwata
Summary: Diabetes mellitus is associated with periodontal disease and affects the efficacy of periodontal treatment. Increased reactive oxygen species (ROS) production in periodontal tissues of diabetic patients contributes to insulin resistance and impairs wound healing and tissue repair. Antioxidants and insulin resistance ameliorants may improve wound healing by inhibiting ROS production. This review comprehensively examines the latest evidence on ROS generation in periodontal tissues, particularly related to microbial challenge and diabetes, and discusses the impact of oxidative stress on wound healing in periodontal and dental implant therapies, as well as the potential benefits of administering antioxidants and anti-insulin resistance medications to counteract ROS production and inflammation.
Article
Biochemistry & Molecular Biology
Maria-Alexandra Martu, Petra Surlin, Luminita Lazar, George Alexandru Maftei, Ionut Luchian, Dorin-Nicolae Gheorghe, Elena Rezus, Vasilica Toma, Liliana-Georgeta Foia
Summary: This study analyzed the effects of three different periodontal disease treatment possibilities on clinical periodontal indexes and oxidative stress markers in gingival crevicular fluid. The results showed that periodontal therapy improved these measurements, with laser and photodynamic therapy treatment providing additional benefits.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Microbiology
Tian-Jiao Li, Yi-hang Hao, Ya-ling Tang, Xin-hua Liang
Summary: Emerging evidence indicates a strong connection between periodontal diseases, including oral cancer. The pathogens responsible for periodontal diseases play a crucial role in the development of oral cancer by directly interacting with the host's epithelium and indirectly creating an inflammatory environment conducive to carcinogenesis. Additionally, the functional properties of the oral microbial community are associated with cancer development. Maintaining oral hygiene is essential for preventing oral diseases, particularly oral cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Biagio Rapone, Elisabetta Ferrara, Erda Qorri, Mir Faeq Ali Quadri, Gianna Dipalma, Antonio Mancini, Massimo Del Fabbro, Antonio Scarano, Gianluca Tartaglia, Francesco Inchingolo
Summary: The study suggests that intensive periodontal treatment may improve endothelial function in diabetic patients, but there were no significant benefits observed in the lipid profile.
Review
Biochemistry & Molecular Biology
Nansi Lopez-Valverde, Beatriz Pardal-Pelaez, Antonio Lopez-Valverde, Javier Flores-Fraile, Silvia Herrero-Hernandez, Bruno Macedo-de-Sousa, Julio Herrero-Payo, Juan Manuel Ramirez
Summary: The natural product propolis has been shown to be effective and safe in treating periodontal disease. Research indicates that propolis can reduce probing pocket depth and improve treatment outcomes.
Review
Immunology
Qingsong Jiang, Yuxi Zhao, Yusen Shui, Xuedong Zhou, Lei Cheng, Biao Ren, Zhu Chen, Mingyun Li
Summary: Late-onset periodontitis is closely related to the interactions between neutrophils and periodontal pathogens, where the balance between neutrophils and the microbial community is crucial. Neutrophils clear pathogens mainly through phagocytosis and release mechanisms, while pathogens evade neutrophil-mediated killing through various strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ahmed Chaudhry, Nur Karyatee Kassim, Siti Lailatul Akmar Zainuddin, Haslina Taib, Hanim Afzan Ibrahim, Basaruddin Ahmad, Muhammad Hafiz Hanafi, Azreen Syazril Adnan
Summary: This study found that inflammatory biomarkers levels were higher in patients with chronic kidney disease (CKD) and chronic periodontitis (CP). After non-surgical periodontal therapy (NSPT), the levels of inflammatory biomarkers in CKD patients significantly reduced, and they showed a good response to the treatment. Therefore, it is important to screen and monitor the periodontal health of CKD patients.
Article
Dentistry, Oral Surgery & Medicine
Praveen Sharma, Anthony Fenton, Irundika H. K. Dias, Brenda Heaton, Caroline L. R. Brown, Amneet Sidhu, Mutahir Rahman, Helen R. Griffiths, Paul Cockwell, Charles J. Ferro, Iain L. Chapple, Thomas Dietrich
Summary: The study found a causal relationship between periodontal inflammation and renal function, mediated by systemic oxidative stress. Periodontal inflammation represents an occult source of oxidative stress in patients with CKD, and periodontal therapy may potentially improve outcomes in CKD by reducing systemic inflammatory/oxidative stress burden.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
