Article
Psychology, Developmental
Eszter Szekely, Alexander Neumann, Hannah Sallis, Alexia Jolicoeur-Martineau, Frank C. Verhulst, Michael J. Meaney, Rebecca M. Pearson, Robert D. Levitan, James L. Kennedy, John E. Lydon, Meir Steiner, Celia M. T. Greenwood, Henning Tiemeier, Jonathan Evans, Ashley Wazana
Summary: This study found that prenatal maternal general affective symptoms and pregnancy-specific worries can independently have adverse effects on offspring psychopathology, further supporting the need for specific interventions during pregnancy.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Krzysztof Kotlarz, Magda Mielczarek, Yachun Wang, Jinhuan Dou, Tomasz Suchocki, Joanna Szyda
Summary: In this study, mixed linear models were applied to analyze the whole transcriptome expression in the livers and adrenal tissues of Sprague-Dawley rats subjected to heat stress. The models explained a significant proportion of the gene expression changes, with certain genes, such as PNKD and TRIP12, being identified as particularly significant. Furthermore, the analysis revealed differences in transcript expression for genes like SUCO and PLEC between the heat-stress group and the control group. Additionally, several Gene Ontologies and one Reactome pathway were found to be significant in liver function regulation.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Wen-Qiong Wei, Hong Sun, Ya-Juan Chen, Xiao-Wen Liu, Rui Zhou, Yi Li, Xin-Wen Liu
Summary: This study identified the association between ADHD and excitatory neurons in the midbrain, visual cortex, and frontal lobe regions through the integration of genetic variants and gene expression data.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Jiayi Li, Wilaiwan Wisessmith Durose, Junko Ito, Akiyoshi Kakita, Yohei Iguchi, Masahisa Katsuno, Kazuo Kunisawa, Takeshi Shimizu, Kazuhiro Ikenaka
Summary: Remyelination is crucial in demyelinating disorders, but can be hindered during chronic disease states. Cystatin F is a key regulator of demyelination and remyelination. Factors such as ELAVL-1 and miR29a play important roles in modulating cystatin F expression, potentially serving as therapeutic targets for demyelinating disorders.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Engineering, Civil
Yukari Jessica Tham, Takaaki Hashimoto, Kaori Karasawa
Summary: This study identifies two dimensions underlying benefit perception and three dimensions underlying risk perception of conditionally/fully automated vehicles. The perception that AVs would decrease harm positively influenced people's intention to use AVs, while the perception of increased convenience had a positive effect on intention to use fully automated vehicles, and the perception of risk to ease of use had a negative effect.
Article
Oncology
Emilio Ugalde-Morales, Felix Grassmann, Keith Humphreys, Jingmei Li, Mikael Eriksson, Nicholas P. Tobin, Ake Borg, Johan Vallon-Christersson, Per Hall, Kamila Czene
Summary: The study revealed an inverse association between higher TC and more aggressive tumor characteristics, potentially influenced by gene expression.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Weijie Gu, Fangning Wan, Jun Chen, Hualei Gan, Beihe Wang, Yu Wei, Guiming Zhang, Jiaquan Zhou, Xuefei Ding, Peipei Zhang, Shengming Jin, Qinghua Xu, Dingwei Ye, Yao Zhu
Summary: This study developed and validated a novel molecular tool for individualized treatment of squamous cell carcinoma (SCC) in patients with node-positive penile SCC. Through the discovery, development, and validation stages, the methylation panel demonstrated significant progress in survival prediction and risk stratification.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Omar Dzaye, Alexander C. Razavi, Erin D. Michos, Martin Bodtker Mortensen, Zeina A. Dardari, Khurram Nasir, Albert D. Osei, Allison W. Peng, Ron Blankstein, John H. Page, Michael J. Blaha
Summary: This study aimed to determine the relationship between coronary artery calcium (CAC) scores and atherosclerotic cardiovascular disease (ASCVD) mortality rates. The study found that primary prevention individuals with increased CAC burden may have ASCVD mortality rates equivalent to persons with stable secondary prevention-level risk.
Article
Acoustics
Jakob Bergner, Juergen Peissig
Summary: This study attempts to identify acoustic dimensions that vary between different acoustic environments and reveals 8 statistically relevant independent dimensions for the description of acoustic environments.
Review
Biochemistry & Molecular Biology
Cosmin Tirdea, Sorin Hostiuc, Horatiu Moldovan, Alexandru Scafa-Udriste
Summary: Acute myocardial infarction is still a leading cause of death globally. This review aims to compile information on genes associated with AMI and conducted a big data analysis. It identified 28 genes that are closely associated with an increased risk for AMI, including LTA, LGALS2, LDLR, and APOA5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Min Zhang, Xiaheng Deng, Ziyan Jiang, Zhiping Ge
Summary: This study revealed the transcriptome classification of preeclampsia cases and identified the genomic characteristics and their correlation with clinical features among different subgroups. The results showed that preeclampsia can be classified into three subgroups: typical, early stage, and proinflammatory subgroups. Potential hub genes and miRNAs were also discovered.
Article
Behavioral Sciences
Sally I-Chun Kuo, Jessica E. Salvatore, Peter B. Barr, Fazil Aliev, Andrey Anokhin, Kathleen K. Bucholz, Grace Chan, Howard J. Edenberg, Victor Hesselbrock, Chella Kamarajan, John R. Kramer, Dongbing Lai, Travis T. Mallard, John I. Nurnberger, Gayathri Pandey, Martin H. Plawecki, Sandra Sanchez-Roige, Irwin Waldman, Abraham A. Palmer, Danielle M. Dick
Summary: Genetic predispositions and environmental influences both play an important role in adolescent externalizing behavior. Results indicate that in the European ancestry sample, externalizing polygenic scores were directly associated with adolescent externalizing behavior and indirectly via peer substance use. However, no significant polygenic association nor indirect effects of genetic risk were observed in the African ancestry group.
Article
Environmental Sciences
Felix M. Onyije, Ann Olsson, Friederike Erdmann, Corrado Magnani, Eleni Petridou, Jacqueline Clavel, Lucia Miligi, Audrey Bonaventure, Daniela Ferrante, Sara Piro, Susan Peters, Roel Vermeulen, Hans Kromhout, Joachim Schuz
Summary: This study investigated the association between parental occupational exposures and the risk of childhood leukemia. The findings suggest a possible link between high paternal occupational exposure to crystalline silica and childhood leukemia. However, there were no significant associations observed for other occupational carcinogens. More research is needed to confirm these findings and explore the mechanistic pathways.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Behavioral Sciences
Valentina Carpentieri, Luca Cerniglia, Silvia Cimino, Mariangela Pucci, Esterina Pascale, Claudio D'Addario, Walter Adriani
Summary: By studying the methylation dynamics of two CpG motifs within the DAT gene, different patterns of cross-correlation were found in individuals with internalizing and externalizing symptoms, while low-risk individuals showed a potential for both patterns. The aim of the study was to identify a specific methylation pattern of DAT as a biomarker for early detection of psycho-pathological deviations.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Neurosciences
Chloe J. Jordan, Zheng-Xiong Xi
Summary: Understanding risk factors for substance use disorders (SUD) is crucial for medication development in SUD treatment. This article reviews recent progress in identifying candidate genes contributing to drug use and addiction using transgenic approaches. The authors highlight the importance of genetic factors in conveying vulnerability to drug use and discuss future research directions in identifying addiction-related risk genes.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)
