Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Xiaohui Yang, Xixia Liu, Fangshen Xu, Shunxian Ji, Yuchao Sun, Zhaojun Song, Jie Song, Yulian Wu, Jun Yin
Summary: In this study, degradable poly(lactic-co-glycolic acid) nerve guide conduits with microgroove or smooth inner surface were fabricated using a phase inversion-based dry-jet wet spinning method for the regeneration of recurrent laryngeal nerve (RLN). The results showed that the conduit with microgroove structure exhibited better cellular behavior and the ability to promote RLN regeneration in an animal model. This study contributes to the design and application of nerve guide conduits and tissue engineering in RLN injury repair.
MATERIALS & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Chisong Lee, Jinkyung Kim, Daniel Junmin Um, Youseong Kim, Hye Su Min, Jiwoo Shin, Jee Hye Nam, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Hyungil Jung
Summary: The study introduced a novel heat-melting method to fabricate hydrophobic PLGA DMNs for transdermal drug delivery, avoiding potentially harmful organic solvents. The implanted HMP-DMNs successfully separated from the patch within 10 minutes and released encapsulated molecules for nearly 4 weeks, demonstrating safe and effective sustained drug delivery without the use of organic solvents. This research offers an innovative approach to utilizing PLGA as a material for transdermal drug delivery systems.
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Article
Pharmacology & Pharmacy
Sankha Bhattacharya
Summary: Polymeric nanoparticles exhibit systematic and target-specific drug delivery properties, staying in the bloodstream for an extended period to enhance drug bioavailability and tissue distribution.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Nasrullah Jan, Asadullah Madni, Safiullah Khan, Hassan Shah, Faizan Akram, Arshad Khan, Derya Ertas, Mohammad F. Bostanudin, Christopher H. Contag, Nureddin Ashammakhi, Yavuz Nuri Ertas
Summary: This article discusses the preparation methods and applications of cell membrane-coated PLGA nanoparticles, as well as their role in cancer therapy, inflammation management, cardiovascular disease treatment, and infection control. It also highlights the challenges and future research directions of cell membrane-camouflaged nanoparticles.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Eva M. M. Eger, Seema Agarwal
Summary: This study focuses on the characterization and reprocessing ability of PLGA in the form of dynamic covalent networks. The synthesized networks with dynamic bonding and debonding have enhanced thermomechanical properties and maintain the potential for thermal reprocessing and recycling like thermoplastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Physical
Banendu Sunder Dash, Yu-Jen Lu, Shu-Hui Luo, Jyh-Ping Chen
Summary: In this study, we prepared PLGA@OMNP@CPT-11 nanoparticles and successfully delivered CPT-11 to U87 primary glioblastoma cells through dual targeting. The nanoparticles showed high drug release efficiency and cytotoxicity. In an orthotopic brain tumor model, intravenous injection of PLGA@OMNP@ CPT-11-CET followed by magnetic guidance resulted in the best treatment efficacy.
Review
Materials Science, Biomaterials
Jagan Mohan Dodda, Tomas Remis, Sadiku Rotimi, Yi-Cheun Yeh
Summary: This article provides an overview of PLGA-based conjugates in cancer research, focusing on their roles as targeted drug carriers and sustained drug controllers. The preparation and drug encapsulation of PLGA nanoparticles and FA-PEG-PLGA conjugates are discussed, with emphasis on the associated chemistries and biocompatibility. This review offers a deeper understanding of PLGA-conjugated materials for successful material design and biomedical applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Yu Sun, Abhishek Bhattacharjee, Melissa Reynolds, Yan Vivian Li
Summary: The study successfully prepared PLGA nanoparticles loaded with gentamicin using a double emulsion method, demonstrating excellent antibacterial properties and potential for fabricating smart wound dressings; by investigating the release profiles of nanoparticles prepared at different PLGA concentrations, the study revealed the involvement of multiple release mechanisms.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Biophysics
Ibrahima Youm, Matthew B. West, Xiangping Huang, Wei Li, Richard D. Kopke
Summary: The effects of sucrose on the physical stability, cellular entry pathways, and functional efficacy of PLGA-NPs were investigated in this study. The results showed that the addition of 10% sucrose significantly improved the physical stability and cellular uptake of HEI-101-NPs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Alastair Little, Alan M. Wemyss, David M. Haddleton, Bowen Tan, Zhaoyang Sun, Yang Ji, Chaoying Wan
Summary: The study investigates the effects of various reaction conditions on the synthesis of PLGA25, showing how factors such as reaction temperature, initiator concentration, and catalyst concentration impact the molecular weight, monomer conversion, and thermal properties.