Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus

Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90

(2020) Adolfo Cuesta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

More than 80 clinical trials launch to test coronavirus treatments

(2020) Amy Maxmen   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Repurposing Clinical Drugs as AdoMetDC Inhibitors Using the SCAR Strategy

(2020) Yan Zhang et al.   Frontiers in Pharmacology

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of Covalent Ligands via Noncovalent Docking by Dissecting Covalent Docking Based on a “Steric-Clashes Alleviating Receptor (SCAR)” Strategy

(2016) Yuanbao Ai et al.   Journal of Chemical Information and Modeling

Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71

(2016) Lanjun Zhang et al.   JOURNAL OF MOLECULAR RECOGNITION

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay

(2015) Chenzeng Liao et al.   Scientific Reports

Cathepsin C Inhibitors: Property Optimization and Identification of a Clinical Candidate

(2014) Mark Furber et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigating the Proteome Reactivity and Selectivity of Aryl Halides

(2014) D. Alexander Shannon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Drug discovery considerations in the development of covalent inhibitors

(2013) Robert Mah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deconstructing the Drug Development Process: The New Face of Innovation

(2010) K I Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS