Journal
BIOINFORMATICS
Volume 36, Issue 12, Pages 3907-3909Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btaa266
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Funding
- National Institutes of Health [GM084089, GM129069]
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Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is dynamically regulated under different growth and differentiation conditions. Here, we present a bioinformatics package, named APAlyzer, for examining 3'UTR APA, intronic APA and gene expression changes using RNA-seq data and annotated polyadenylation sites in the PolyA_DB database. Using APAlyzer and data from the GTEx database, we present APA profiles across human tissues.
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