Journal
BIOCONJUGATE CHEMISTRY
Volume 31, Issue 4, Pages 1088-1092Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.0c00175
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Funding
- Ministe`re de l'Enseignement Superieur et de la Recherche
- Centre National de la Recherche Scientifique (CNRS)
- Conseil Regional de Bourgogne [20159205AAO033S04139/BG0003203]
- French Research National Agency (ANR) via project JCJC SPID [ANR-16CE07-0020]
- French Research National Agency (ANR) via project JCJC WazaBY [ANR-18-CE18-0012]
- GEFLUC Grenoble Dauphine Savoie
- FLI (France Life Imaging)
- CNRS Mission for Transversal and Interdisciplinary Initiatives
- Fondation pour la Recherche Medicale (FRM) [FRM ECO201806006861]
- Plan Cancer funding [C18038CS]
- Universite de Bourgogne through the Plan d'Actions Regional pour l'Innovation (PARI)
- European Union through the PO FEDER-FSE Bourgogne 2014/2020 programs
- German Research Council (DFG) [1203/12-3]
- Conseil Regional de Bourgogne through the Plan d'Actions Regional pour l'Innovation (PARI)
- Agence Nationale de la Recherche (ANR) [ANR-18-CE18-0012] Funding Source: Agence Nationale de la Recherche (ANR)
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A simple NIR-II emitting water-soluble system has been developed and applied in vitro and in vivo. In vitro, the fluorophore quickly accumulated in 2D and 3D cell cultures and rapidly reached the tumor in rodents, showing high NIR-II contrast for up to 1 week. This very efficient probe possesses all the qualities necessary for translation to the clinic as well as for the development of NIR-II emitting materials.
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