Article
Oncology
Irene Bagaloni, Axel Visani, Sara Biagiotti, Annamaria Ruzzo, Mohsen Navari, Maryam Etebari, Lucia Mundo, Massimo Granai, Stefano Lazzi, Alessandro Isidori, Federica Loscocco, Jiejin Li, Lorenzo Leoncini, Giuseppe Visani, Mauro Magnani, Pier Paolo Piccaluga
Summary: The study revealed enhanced glucose metabolism in most lymphoma subtypes, with a general shift to aerobic glycolysis. Not only aggressive lymphomas, but also indolent ones like marginal zone lymphomas, showed this phenomenon. Metformin was shown to induce cell death in BL cells by affecting cellular metabolism.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Ke Xu, Na Yin, Min Peng, Efstathios G. Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H. Do, Kristelle J. Capistrano, Chun Chou, Christina S. Leslie, Ming O. Li
Summary: The Warburg effect, characterized by aerobic glycolysis, is an important metabolic feature of effector T cells, driving their responses through ATP production via LDHA. LDHA deficiency impairs T cell activation, proliferation, and differentiation by disrupting the PI3K-Akt-Foxo1 signaling pathway. This study highlights the crucial role of Warburg metabolism in regulating effector T cell responses.
Article
Medicine, Research & Experimental
Xiaojing Wang, Hongchao He, Wenbin Rui, Ning Zhang, Yu Zhu, Xin Xie
Summary: The study identified TRIM38 as a tumor suppressor in BLCA, which interacts with GLUT1 to regulate cell characteristics and glycolysis, providing a potential therapeutic target for BLCA treatment. Targeting the TRIM38/GLUT1 axis effectively suppresses BLCA growth and progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Chithravel Vadivalagan, Anand Krishnan, Siang-Jyun Chen, You-Cheng Hseu, Sathish Muthu, Rajib Dhar, Alaa A. A. Aljabali, Murtaza M. Tambuwala
Summary: Osteoporosis is a common disease in elderly people and currently lacks effective treatment options. Women after menopause are particularly prone to osteoporosis, and hormone-related pathways are considered important in combating the disease. Energy metabolism plays a key role in the development of osteoporosis, and understanding the energy pathways associated with the disease can provide clues for the development of treatment strategies.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Yi Xu, Lily Tran, Janet Tang, Vinh Nguyen, Elisabeth Sewell, Jeffrey Xiao, Christopher Hino, Samiksha Wasnik, Olivia L. Francis-Boyle, Ke K. Zhang, Linglin Xie, Jiang F. Zhong, David J. Baylink, Chien-Shing Chen, Mark E. Reeves, Huynh Cao
Summary: Acute myeloid leukemia (AML) is the most common form of blood cancer in adults, and downregulation of fructose-1,6-bisphosphatase 1 (FBP1) in cancer cells is associated with carcinogenesis and disease progression. However, restoration of FBP1 activity in cancer cells promotes apoptosis and prevents disease progression in solid tumors. In AML blasts, activation of FBP1 can induce cell death through mitochondrial reprogramming, highlighting the potential clinical application of FBP1-based therapies for AML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yi Wu, Keshi Chen, Linpeng Li, Zhihong Hao, Tianyu Wang, Yang Liu, Guangsuo Xing, Zichao Liu, Heying Li, Hao Yuan, Jianghuan Lu, Cheng Zhang, Jinye Zhang, Danyun Zhao, Junwei Wang, Jinfu Nie, Dan Ye, Guangjin Pan, Wai-Yee Chan, Xingguo Liu
Summary: This study reveals the critical role of Plin2-mediated lipid hydrolysis in embryonic stem cell pluripotency. The degradation of Plin2 facilitates lipid droplet mobilization, and excessive lipid hydrolysis leads to lipidomic remodeling, defects in mitochondrial structure and fatty acid oxidation, resulting in the loss of pluripotency.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Environmental Sciences
Yatao Du, Bin Wang, Zhenzhen Cai, Huihui Zhang, Bo Wang, Wei Liang, Guangdi Zhou, Fengxiu Ouyang, Weiye Wang
Summary: Various research groups have shown that TCS can increase the biosynthesis of steroid hormones in different types of cells, but the exact toxic mechanism at a molecular level is still unclear. This study focuses on how TCS affects energy metabolism to increase steroidogenesis in human ovarian cells, demonstrating a shift in glucose flow towards steroid hormone biosynthesis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Jianxu Wei, Xiaomeng Zhang, Zhuo Zhang, Xinxin Ding, Yuan Li, Yi Zhang, Xue Jiang, Hongbo Zhang, Hongchang Lai, Junyu Shi
Summary: Metabolic energy can be a therapeutic target for bone tissue engineering by manipulating osteoblastic differentiation of bone marrow mesenchymal stem cells (BMSCs). Curcumin can activate glucose transporter 1 (GLUT1) to promote osteogenic differentiation of BMSCs and enhance bone regeneration. Cholesterol/lipid raft (Cho/LR) acts as a sensor to trigger GLUT1 switch, facilitating bone regeneration. These findings have significant implications for bone tissue engineering.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Andrew Blum, Kate Mostow, Kailey Jackett, Estelle Kelty, Tenzing Dakpa, Carly Ryan, Engda Hagos
Summary: The study indicates that KLF4 plays a role in regulating cell metabolism and promoting energy production, which may be beneficial for cancer treatment.
Review
Biochemistry & Molecular Biology
Chaithanya Chelakkot, Vipin Shankar Chelakkot, Youngkee Shin, Kyoung Song
Summary: Cancer cells undergo metabolic reprogramming to adopt a glycolysis-dominant metabolic profile, providing them with a survival advantage and contributing to a pro-cancerous tumor environment. This metabolic switch also leads to increased resistance to chemotherapy and radiation. Immune cells in the tumor microenvironment also exhibit a similar metabolic shift, leading to competition with cancer cells for nutrients. Targeting enhanced glycolysis in cancer cells has shown promise in improving treatment efficacy, but effective strategies are still lacking. This review highlights the importance of metabolic reprogramming in cancer cells and the potential of targeting it to enhance conventional cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaojian Tang, Fengli Li
Summary: This study aimed to investigate the role of EMILIN2 in ovarian cancer and its related mechanisms. The results showed that down-regulated EMILIN2 was associated with poor prognosis in ovarian cancer, while its overexpression could regulate the metabolic phenotype of ovarian cancer cells. Furthermore, the expression of EMILIN2 was epigenetically regulated by its promoter region methylation, and p53 was found to regulate the expression of EMILIN2 and the Warburg effect in ovarian cancer cells through the p53/EMILIN2 axis.
JOURNAL OF BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Guoli Hu, Yilin Yu, Deepika Sharma, Shondra M. Pruett-Miller, Yinshi Ren, Guo-Fang Zhang, Courtney M. Karner
Summary: Reactive oxygen species (ROS) negatively impact osteoblast differentiation and bone formation by inhibiting the stability of the RUNX2 protein, which is a molecular sensor of the osteoblast REDOX environment. The synthesis of glutathione (GSH) is essential in neutralizing ROS and establishing a proosteogenic REDOX environment. Antioxidant therapy can stabilize RUNX2 and improve bone development in certain bone disorders.
Article
Pharmacology & Pharmacy
Isobel C. C. Jones, Revathy Carnagarin, Jo Armstrong, Daphne P. L. Lin, Mia Baxter-Holland, Mina Elahy, Crispin R. R. Dass
Summary: It has been found that PEDF can influence the insulin signaling pathway by inhibiting the phosphorylation of insulin receptor and insulin receptor substrate in skeletal myocytes. Moreover, PEDF can promote the transdifferentiation of adipocytes into osteoblasts, leading to bone formation in vitro and in vivo. Additionally, PEDF is associated with the anticancer drug doxorubicin and cellular metabolism.
Article
Endocrinology & Metabolism
Linlin Zhang, Kecheng Zhu, Jingzun Xu, Xiaojing Chen, Chunxiang Sheng, Deng Zhang, Yuying Yang, Lihao Sun, Hongyan Zhao, Xiao Wang, Bei Tao, Libin Zhou, Jianmin Liu
Summary: CBP and p300, as important histone acetyltransferases, have been found to affect bone density and strength. The study further demonstrates that CBP/p300 HAT regulates osteogenic gene expression by modulating transcription of beta-catenin and Stat1. These findings reveal an epigenetic mechanism responsible for maintaining bone homeostasis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Immunology
Ivan J. Cohen, Fresia Pareja, Nicholas D. Socci, Ronglai Shen, Ashley S. Doane, Jazmin Schwartz, Raya Khanin, Elizabeth A. Morris, Elizabeth J. Sutton, Ronald G. Blasberg
Summary: This study reveals an inverse relationship between tumor glycolysis and immune infiltration in a large cohort of multiple solid tumor types.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chang-Hwan Seong, Norika Chiba, Joji Kusuyama, Muhammad Subhan Amir, Nahoko Eiraku, Sachiko Yamashita, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi
Summary: BMP9 induces periodic increases of Hes1 mRNA and protein expression in osteoblasts through an autocrine negative feedback mechanism, which is significantly inhibited by an ALK inhibitor and overexpression of inhibitory Smad7. The transcriptional activation of Hes1 by BMP9 in osteoblasts is dependent on two Smad-binding sites in the upstream region of the gene.
Article
Cell Biology
Joji Kusuyama, Ana Barbara Alves-Wagner, Royce H. Conlin, Nathan S. Makarewicz, Brent G. Albertson, Noah B. Prince, Shio Kobayashi, Chisayo Kozuka, Magnus Moller, Mette Bjerre, Jens Fuglsang, Emily Miele, Roeland J. W. Middelbeek, Yang Xiudong, Yang Xia, Lea Garneau, Jayonta Bhattacharjee, Celine Aguer, Mary Elizabeth Patti, Michael F. Hirshman, Niels Jessen, Toshihisa Hatta, Per Glud Ovesen, Kristi B. Adamo, Eva Nozik-Grayck, Laurie J. Goodyear
Summary: Poor maternal diet increases the risk of obesity and type 2 diabetes in offspring, while maternal exercise improves their metabolic health. The increase in placenta-derived SOD3 through maternal exercise activates an AMPK/TET signaling axis in the fetal offspring liver, resulting in improved glucose tolerance and liver function. This cross talk between SOD3 and offspring liver provides a central mechanism for enhancing offspring metabolic health.
Article
Oncology
Li-Min Zhu, Hai-Xia Shi, Masahiro Sugimoto, Kenjiro Bandow, Hiroshi Sakagami, Shigeru Amano, Hai-Bin Deng, Qing-Yu Ye, Yun Gai, Xiao-Li Xin, Zhen-Ye Xu
Summary: Feiyanning formula (FYN) is a traditional Chinese medicine prescription used for treating lung cancer for over 20 years. Through network pharmacological analysis, it was found that FYN can inhibit lung cancer growth by activating the mitochondrial pathway and inducing apoptosis in cancer cells, supporting the validity of the prediction.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Joji Kusuyama, Nathan S. Makarewicz, Brent G. Albertson, Ana Barbara Alves-Wagner, Royce H. Conlin, Noah B. Prince, Christiano R. R. Alves, Krithika Ramachandran, Chisayo Kozuka, Yang Xiudong, Yang Xia, Michael F. Hirshman, Toshihisa Hatta, Ryoichi Nagatomi, Eva S. Nozik, Laurie J. Goodyear
Summary: Maternal exercise is a promising intervention to reduce the transmission of multigenerational metabolic dysfunction caused by maternal obesity. It benefits offspring health through DNA demethylation of critical hepatic genes. The effects of maternal obesity and exercise on histone methylation in offspring are not known.
Article
Biochemistry & Molecular Biology
Norika Chiba, Yukie Noguchi, Chang Hwan Seong, Tomokazu Ohnishi, Tetsuya Matsuguchi
Summary: This study reveals the important role of EGR1 in BMP9-induced osteoblast differentiation, enhancing SMAD1/5 phosphorylation.
Article
Biochemistry & Molecular Biology
Kotone Naitoh, Yuta Orihara, Hiroshi Sakagami, Takumi Miura, Keitaro Satoh, Shigeru Amano, Kenjiro Bandow, Yosuke Iijima, Kota Kurosaki, Yoshihiro Uesawa, Masashi Hashimoto, Hidetsugu Wakabayashi
Summary: This study reveals the antitumor potential of 4,6,8-trimethyl azulene amide derivatives against oral malignant cells and their relatively lower neurotoxicity compared to commonly used anticancer drugs. Compounds 7 and 15 may serve as potential lead compounds for novel anticancer drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Muhammad Subhan Amir, Norika Chiba, Chang Hwan Seong, Joji Kusuyama, Nahoko Eiraku, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi
Summary: BMP9 increases the expression of HIF-1α protein in osteoblasts under normoxic conditions, and this induction is mediated by the PI3K-AKT signaling pathway and the inhibition of PHD-mediated protein degradation. It also promotes osteoblast differentiation by inducing the expression of PDK1.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ana B. Alves-Wagner, Joji Kusuyama, Pasquale Nigro, Krithika Ramachandran, Nathan Makarewicz, Michael F. Hirshman, Laurie J. Goodyear
Summary: Recent pre-clinical studies have found that exercise before and during pregnancy can improve the risk of metabolic diseases transmitted from obese mothers to offspring. This study further demonstrates that exercise by grandmothers can have beneficial effects on the metabolic health of their grandoffspring, including improvements in glucose tolerance, reduction in fat mass, and improved liver metabolic function.
MOLECULAR METABOLISM
(2022)
Article
Dentistry, Oral Surgery & Medicine
Tomokazu Ohnishi, Toshiaki Nakamura, Kaori Shima, Kazuyuki Noguchi, Norika Chiba, Tetsuya Matsuguchi
Summary: Periodontitis increases the expression of TMPRSS2 in gingival keratinocytes, which is responsible for activating the fusion protein of SARS-CoV-2. Analysis of gene expression and experimental models showed increased TMPRSS2 expression in gingiva of periodontitis patients. Further investigation identified transcription factors such as ESR1 that are associated with TMPRSS2 expression.
JOURNAL OF ORAL BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Janos Negyesi, Peter Negyesi, Tibor Hortobagyi, Sai Sun, Joji Kusuyama, Rita M. Kiss, Ryoichi Nagatomi
Summary: This study examined the effects of handedness and task complexity on motor skill acquisition and interlimb transfer. The results showed that right-handed participants performed the motor sequence task faster with their right hand. However, handedness did not affect motor skill acquisition or transfer regardless of task complexity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kenjiro Bandow, Avi Smith, Jonathan Garlick
Summary: TREM2 is the causative gene for Nasu-Hakola disease, associated with bone cysts and leukoencephalopathy, and is also linked to the onset of Alzheimer's disease. TREM2 is expressed on immune cells and can be shed from the cell membrane as soluble TREM2 (sTREM2). Research has shown that sTREM2 has cytokine-like functions in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Dermatology
Kenjiro Bandow, Avi Smith, Trishawna Watkins, Sasha Shenk, Behzad Gerami-Naini, Jonathan. A. A. Garlick
Summary: This study investigated the role of chemokines in a three-dimensional skin-equivalent tissue model and found that CCL20 promotes the synthesis of collagen Type I during myofibroblast differentiation. Knocking down the CCL20 gene in fibroblasts decreased collagen Type I synthesis and stromal thickness.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osorio Leiria, Matthew Spite, Yu-Hua Tseng
Summary: The study found that cold exposure can improve obesity-induced inflammation and insulin resistance, and enhance glucose tolerance. The beneficial effects are dependent on brown adipose tissue (BAT) and liver. The researchers discovered that cold and beta 3-adrenergic stimulation promote the production of MaR2 from BAT, which reduces inflammation in obesity, particularly targeting macrophages in the liver.
