ACE-domain selectivity extends beyond direct interacting residues at the active site

Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization

(2019) Zakir Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP

(2019) Duo-Yao Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structures of sampatrilat and sampatrilat-Asp in complex with human ACE - a molecular basis for domain selectivity

(2018) Gyles E. Cozier et al.   FEBS Journal

Angiotensin-converting enzyme in innate and adaptive immunity

(2018) Kenneth E. Bernstein et al.   Nature Reviews Nephrology

Molecular Basis for Multiple Omapatrilat Binding Sites within the ACE C-Domain: Implications for Drug Design

(2018) Gyles E. Cozier et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Design and Development of a Potent and Selective Novel Diprolyl Derivative That Binds to the N-Domain of Angiotensin-I Converting Enzyme

(2017) Stephen Fienberg et al.   JOURNAL OF MEDICINAL CHEMISTRY

The influence of angiotensin converting enzyme mutations on the kinetics and dynamics of N-domain selective inhibition

(2016) Lizelle Lubbe et al.   FEBS Journal

Diffraction-geometry refinement in theDIALSframework

(2016) David G. Waterman et al.   Acta Crystallographica Section D-Structural Biology

Current challenges in peptide-based drug discovery

(2014) Laszlo Otvos et al.   Frontiers in Chemistry

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fragment-based design for the development of N-domain-selective angiotensin-1-converting enzyme inhibitors

(2013) Ross G. Douglas et al.   CLINICAL SCIENCE

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)

(2013) Christopher J. Yates et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme

(2012) Rajni K. Sharma et al.   BIOLOGICAL CHEMISTRY

A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis

(2012) Hong Xu et al.   PLoS One

Presenting your structures: theCCP4mgmolecular-graphics software

(2011) S. McNicholas et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The N Domain of Human Angiotensin-I-converting Enzyme

(2010) Colin S. Anthony et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme

(2009) Wendy L. Kröger et al.   BIOCHEMISTRY

Aβ42-to-Aβ40- and Angiotensin-converting Activities in Different Domains of Angiotensin-converting Enzyme

(2009) Kun Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiotensin-Converting Enzyme C-Terminal Catalytic Domain Is the Main Site of Angiotensin I Cleavage In Vivo

(2007) Sebastien Fuchs et al.   HYPERTENSION