Article
Engineering, Biomedical
Xue Bai, Hongyan Sun, Lina Jia, Junjie Xu, Peng Zhang, Deyuan Zhang, Yu Gu, Bo Chen, Lin Feng
Summary: This study found that gold nanoparticles (AuNPs) can partially protect children's cartilage from inflammatory damage. In a model of LPS-induced cartilage damage, AuNPs inhibited chondrocyte apoptosis and extracellular matrix degradation, resulting in reduced release of inflammatory cytokines and degradation factors. This leads to a decrease in cartilage destruction.
MATERIALS TODAY BIO
(2023)
Article
Biochemistry & Molecular Biology
Shikun Zhang, Binghui Liu, Wenjuan Wang, Luye Lv, Dunqin Gao, Mi Chai, Mansheng Li, Zhihong Wu, Yunping Zhu, Jie Ma, Ling Leng
Summary: Through large-scale quantitative proteomic analysis, this study identified differential expression of dermal ECM components in patients with keloids, which could contribute to keloid formation. The results indicate that skin mechanical properties and biological processes are disrupted in keloids, potentially involving multiple signaling pathways.
Article
Oncology
Qizhi Qin, Mario Gomez-Salazar, Robert J. Tower, Leslie Chang, Carol D. Morris, Edward F. McCarthy, Kang Ting, Xinli Zhang, Aaron W. James
Summary: The study reveals that NELL1, a secreted glycoprotein, plays a crucial role in sarcoma progression and prognosis by modulating cell invasion potential. Deletion of NELL1 significantly reduces metastasis and disease progression in osteosarcoma, both in human and mouse models. Further analysis shows that NELL1 loss alters the expression of matricellular proteins associated with cell signaling.
Article
Oncology
Pekka Rappu, Ujjwal Suwal, Elina Siljamaki, Jyrki Heino
Summary: It has been discovered that the citrullination of matrisome proteins occurs in human cancers, with variations between different tumors. Fibrinogen and fibronectin are the most frequently citrullinated proteins, which are typically associated with inflammation. Further analysis using three-dimensional cell cocultures suggests that cancer cells and fibroblasts cannot citrullinate matrisome proteins in the tumor stroma, and the citrullination of matrisome proteins may be protected in spheroid cultures.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesco Demetrio Lofaro, Barbara Cisterna, Maria Assunta Lacavalla, Federico Boschi, Manuela Malatesta, Daniela Quaglino, Carlo Zancanaro, Federica Boraldi
Summary: This study characterized the matrisome in the aging skeletal muscle for the first time, demonstrating significant statistical differences in several matrisome proteins between aged and adult muscle. The findings provide new insights into the mechanisms regulating myocellular behavior in aging and their contribution to age-related muscle dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Margaret Downs, Manveen K. Sethi, Rekha Raghunathan, Matthew D. Layne, Joseph Zaia
Summary: In this study, the matrisome proteins in Parkinson's disease (PD) were analyzed and significant differences were found in the expression of collagen proteins compared to control samples. Histological analysis supported these findings and showed similar trends in collagen abundance. The hydroxyprolination of collagen was less variable in PD compared to controls, and glycoproteomic changes were observed. Network topology-based analysis revealed the involvement of angiogenesis-related proteins in PD. Further studies with a larger cohort are needed to validate these results.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Elina A. Pietilae, Jordi Gonzalez-Molina, Lidia Moyano-Galceran, Sanaz Jamalzadeh, Kaiyang Zhang, Laura Lehtinen, S. Pauliina Turunen, Tomas A. Martins, Okan Gultekin, Tarja Lamminen, Katja Kaipio, Ulrika Joneborg, Johanna Hynninen, Sakari Hietanen, Seija Grenman, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpen, Joseph W. Carlson, Kaisa Lehti
Summary: The study reveals that platinum chemotherapy enhances resistance by changing cancer cell adhesion signaling and ECM. The heterogeneity of fibrotic ECM in primary tumors and metastatic sites of HGSC before and after chemotherapy provides insights into cancer aggressiveness and potential treatment strategies. The upregulation of COL6 in metastatic HGSCs post-chemotherapy contributes to resistance and relapse, highlighting the importance of targeting the ECM pathway for therapeutic intervention.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Melanie Salamito, Benjamin Gillet, Delfien Syx, Elisabeth Vaganay, Marilyne Malbouyres, Catherine Cerutti, Nicolas Tissot, Chloe Exbrayat-Heritier, Philippe Perez, Christophe Jones, Sandrine Hughes, Fransiska Malfait, Valerie Haydont, Sibylle Jager, Florence Ruggiero
Summary: NRF2 regulates the expression of extracellular matrix (ECM) genes in dermal fibroblasts, and its downregulation leads to reduced collagen synthesis and fibril deposition. ZNF469, a potential transcriptional regulator of collagen biosynthesis, is identified as a target of NRF2. These findings highlight the important role of NRF2 in maintaining dermal ECM homeostasis and provide potential targets for skin health and aging.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rebecca Preston, Qing-Jun Meng, Rachel Lennon
Summary: The circadian clock network in mammals is responsible for regulating various physiological processes in the body. Kidney disease is associated with the circadian system and extracellular matrix. Recent evidence suggests that cell-matrix interactions and the biomechanical properties of the matrix play a crucial role in regulating peripheral circadian rhythms. Studying the kidney matrisome can provide insights into the interactions between the extracellular matrix and intracellular time-keeping mechanisms.
Article
Engineering, Biomedical
Pengfei Guan, Can Liu, Denghui Xie, Shichao Mao, Yuelun Ji, Yongchang Lin, Zheng Chen, Qiyou Wang, Lei Fan, Yongjian Sun
Summary: Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation and limb growth defects in children. The researchers developed an exosome-derived hydrogel that directly supplements extracellular matrix and inhibits inflammation to promote cartilage repair. The hydrogel significantly enhanced extracellular matrix synthesis and facilitated growth plate injury repair through ECM remodeling.
BIOACTIVE MATERIALS
(2022)
Article
Polymer Science
Alexandros Chremos, Jack F. Douglas, Peter J. Basser, Ferenc Horkay
Summary: This study computationally investigates a composite hydrogel as a biomimetic model to mimic the unique load-bearing properties of articular cartilage, and reveals that the emergence of prestress in the composite gels is primarily caused by the stiffness of the polymer matrix and the asymmetry in the enthalpic interactions.
Article
Biochemistry & Molecular Biology
Aleksander M. Haack, Christopher M. Overall, Ulrich auf dem Keller
Summary: The extracellular matrix (ECM) is composed of proteins secreted by cells and plays a crucial role in maintaining tissue homeostasis and cellular control. Aberrant signaling through the ECM can lead to various pathological conditions. Therefore, characterizing the components of the ECM and developing novel therapeutics are of great importance.
Article
Biochemical Research Methods
Yungang He, Pingmeng Deng, Ying Yan, Luying Zhu, Hongying Chen, Ting Li, Yong Li, Jie Li
Summary: This study investigates the role of tumor extracellular matrix (ECM) in the progression of oral squamous cell carcinoma (OSCC). The findings show significant differences between tumor ECM and normal ECM, and demonstrate the influence of tumor ECM on OSCC cell proliferation, apoptosis, migration, and macrophage polarization. This study highlights the importance of tumor ECM in understanding the mechanisms of OSCC and improving treatment outcomes.
JOURNAL OF PROTEOMICS
(2022)
Article
Oncology
Elisa Holstein, Annalena Dittmann, Anni Kaariainen, Vilma Pesola, Jarkko Koivunen, Taina Pihlajaniemi, Alexandra Naba, Valerio Izzi
Summary: Mutations play a crucial role in the oncogenic process by altering regulatory pathways and leading to uncontrolled cell proliferation. While mutations in intracellular proteins are well understood, less is known about mutations in extracellular matrix-associated proteins. This study highlights the specificity of mutations affecting post-translational modification sites in the extracellular matrix and their potential impact on the tumor microenvironment.
Article
Biochemical Research Methods
Melissa Dussoyer, Adeline Page, Frederic Delolme, Patricia Rousselle, Alexander Nystroem, Catherine Moali
Summary: Four protocols for enriching ECM proteins in adult mouse back skin all led to significant enrichment (up to 65%) of matrisome proteins, with decellularization and solubility profiling protocols yielding the best results. Skin matrisome proteins exhibit diverse solubility and abundance profiles.
JOURNAL OF PROTEOMICS
(2022)
Article
Engineering, Biomedical
Pierluca Pitacco, Joanna M. Sadowska, Fergal J. O'Brien, Daniel J. Kelly
Summary: This study demonstrates the use of 3D bioprinting to engineer mechanically-reinforced cartilaginous templates for large bone defect regeneration. The study found that hypertrophic grafts engineered using TGF-beta 3 and BMP-2 supported higher levels of blood vessel infiltration and accelerated bone regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Pedro J. Diaz-Payno, Maria Kalogeropoulou, Iain Muntz, Esther Kingma, Nicole Kops, Matteo D'Este, Gijsje H. Koenderink, Lidy E. Fratila-Apachitei, Gerjo J. V. M. van Osch, Amir A. Zadpoor
Summary: A 4D biofabrication method for cartilage engineering is reported, which uses a smart multi-material system to create shape-changing constructs. By printing two different ink formulations with differential swelling, the scaffold self-bends to achieve the desired shape. High cell viability is demonstrated in a bioprinted formulation with human bone marrow cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Xavier Barcelo, Kian F. Eichholz, Ines F. Goncalves, Orquidea Garcia, Daniel J. Kelly
Summary: This study demonstrates a biofabrication strategy using inkjet bioprinting to engineer fibrocartilage tissues with user-defined collagen architectures. The scaffold architecture was found to influence the spatial organization of the collagen network, and higher aspect ratios supported the formation of structurally anisotropic tissues. This technology could potentially provide new treatment options for damaged and diseased meniscal tissue.
ACTA BIOMATERIALIA
(2023)
Article
Cell & Tissue Engineering
Ross Burdis, Gabriela S. Kronemberger, Daniel J. Kelly
Summary: Engineering clinically relevant musculoskeletal tissues at a human scale is challenging. Scaffold-free approaches for engineering cartilage tissues have shown promise, but the absence of a supporting scaffold or hydrogel hinders large-scale tissue development.
TISSUE ENGINEERING PART C-METHODS
(2023)
Article
Biotechnology & Applied Microbiology
Selcan Guler, Kian Eichholz, Farhad Chariyev-Prinz, Pierluca Pitacco, Halil Murat Aydin, Daniel J. Kelly, Ibrahim Vargel
Summary: In this study, a biocompatible and bioactive scaffold for bone tissue engineering (BTE) was fabricated using poly(glycerol sebacate) (PGS) and decellularized bone extracellular matrix (deB ECM). The optimized scaffold showed improved initial cell attachment, osteogenesis, mechanical strength, degradation rate, pH change, and wettability. The small-pore-sized and 28% (w/w) bone-inserted scaffolds demonstrated better osteogenic differentiation of mesenchymal stem cells (MSCs).
BIOENGINEERING-BASEL
(2023)
Article
Engineering, Biomedical
Lianne C. Shanley, Olwyn R. Mahon, Sinead A. O'Rourke, Nuno G. B. Neto, Michael G. Monaghan, Daniel J. Kelly, Aisling Dunne
Summary: Recent studies have shown that immune cells undergo metabolic reprogramming upon activation, and exploiting this process has therapeutic potential. This study demonstrates for the first time that the size of hydroxyapatite particles can impact macrophage metabolism, with micron-sized particles promoting a pro-inflammatory phenotype through glycolysis. This highlights immunometabolism as a targetable aspect of the immune response for therapeutic benefit and informs intelligent biomaterial design.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Fiona E. Freeman, Pere Dosta, Lianne C. Shanley, Natalia Ramirez Tamez, Cristobal Riojas J. Javelly, Olwyn R. Mahon, Daniel J. Kelly, Natalie Artzi
Summary: This study investigates the potential of miR-29b to suppress osteosarcoma tumors and normalize bone dysregulation caused by the tumor. The delivery of miR-29b along with systemic chemotherapy significantly decreases tumor burden, increases mouse survival, and decreases osteolysis, thereby normalizing bone homeostasis.
ADVANCED MATERIALS
(2023)
Article
Biophysics
Farhad Chariyev-Prinz, Alex Szojka, Nuno Neto, Ross Burdis, Michael G. Monaghan, Daniel J. Kelly
Summary: Mechanical stimulation can modulate the chondrogenic differentiation of stem/progenitor cells, but its effect on functional articular cartilage engineering using human mesenchymal stem cells (hMSCs) may not be necessary if other culture conditions have been optimized. This study investigated the impact of cell seeding densities and fibrin concentrations on chondrogenesis of hMSCs and found that high cell densities were more supportive of sGAG deposition, while lower fibrin concentrations promoted more robust chondrogenesis. Mechanical stimulation had limited effect on cartilage-specific matrix production, except when hMSCs were first primed with TGF-beta 3. These findings suggest that mechanical stimulation may not be essential for engineering functional articular cartilage grafts, but can be used to understand tissue response to mechanical loading in vivo.
JOURNAL OF BIOMECHANICS
(2023)
Article
Engineering, Biomedical
Ian T. Whelan, Ross Burdis, Somayeh Shahreza, Emad Moeendarbary, David A. Hoey, Daniel J. Kelly
Summary: Endochondral ossification (EO) is a critical biological process for bone development and healing. However, understanding of this process is limited, preventing effective treatment of dysregulated EO. The lack of predictive in vitro models is a key factor, and microphysiological systems offer an advanced platform for research. In this study, a microphysiological model of vascular invasion into developing/regenerating bone was developed, mimicking the process of EO. This model successfully replicated key events in EO and could be used for further research and drug testing.
Editorial Material
Engineering, Biomedical
Daniel J. Kelly, Marcy Zenobi-Wong
Article
Multidisciplinary Sciences
Sebastien J. P. Callens, Daniel Fan, Ingmar A. J. van Hengel, Michelle Minneboo, Pedro J. Diaz-Payno, Molly M. Stevens, Lidy E. Fratila-Apachitei, Amir A. Zadpoor
Summary: The organization of bone cells in landscapes with varying curvatures was studied, revealing a preference for local concavities, multicellular bridging, and collective stress fiber orientation.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Xavier Barcelo, Orquidea Garcia, Daniel J. Kelly
Summary: The meniscus is a crucial tissue in the knee joint, but its limited regenerative capacity has driven the development of tissue engineering approaches. In this study, melt electrowriting was used to create structured scaffolds, and enzymatic treatment was employed to enhance collagen network maturity. This resulted in the development of engineered meniscus tissues with improved mechanical properties.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Piotr Gierlich, Claire Donohoe, Kevin Behan, Daniel J. Kelly, Mathias O. Senge, Ligia C. Gomes-da-Silva
Summary: A pH-sensitive hydrogel formulation was developed for intratumoral injection, enabling sustained release of photosensitizers and achieving optimal therapeutic outcomes through multiple light exposures.
Article
Engineering, Biomedical
Ross Burdis, Xavier Barcelo Gallostra, Daniel J. Kelly
Summary: Scaffold-free tissue engineering can generate more hyaline-like cartilage tissue compared to single-cell scaffold-free approaches. Temporal enzymatic treatment can enhance microtissue fusion and tissue remodeling, leading to the formation of a denser and more biomimetic zonal collagen network. This study demonstrates that using biological building blocks can be improved by using temporal enzymatic treatment during graft development.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Kian F. Eichholz, Pierluca Pitacco, Ross Burdis, Farhad Chariyev-Prinz, Xavier Barcelo, Brooke Tornifoglio, Ryan Paetzold, Orquidea Garcia, Daniel J. Kelly
Summary: This study demonstrates the potential of integrating different additive manufacturing approaches, specifically MEW and FDM, for the development of regenerative biomaterials. By leveraging the advantages of these two methods, hybrid MEW-FDM constructs are able to achieve enhanced bone healing outcomes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
