Article
Endocrinology & Metabolism
Meghan S. Perkins, Renate Louw-du Toit, Hayley Jackson, Mishkah Simons, Donita Africander
Summary: This study found that the newer-generation progestin drospirenone has the weakest proliferation ability in breast cancer cells, while the older progestins medroxyprogesterone acetate and norethisterone have stronger abilities. Progestins play an important role in the risk and mechanism of breast cancer. Further research is needed to investigate the effects of different progestins on breast tissue and their suitability in breast cancer treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Johanna Simin, Habiba Khodir, Romina Fornes, Rulla M. Tamimi, Nele Brusselaers
Summary: This Swedish population-based matched cohort study investigated the association between menopausal hormones and the risk of all-cause, cardiovascular, and cancer-specific mortality. The results showed a slight decrease in the odds of all-cause and cancer-related mortality with the use of menopausal hormones, while the association with cardiovascular mortality was inconsistent. Estrogen-only therapy was associated with increased odds of all-cause and cardiovascular mortality among older women who began treatment at a later age.
Article
Medicine, Research & Experimental
Marie Shamseddin, Fabio De Martino, Celine Constantin, Valentina Scabia, Anne-Sophie Lancelot, Csaba Laszlo, Ayyakkannu Ayyannan, Laura Battista, Wassim Raffoul, Marie-Christine Gailloud-Matthieu, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, George Sflomos, Cathrin Brisken
Summary: The study found that different progestins have varied effects on breast epithelial cell proliferation, thereby influencing breast cancer risk. Androgenic progestins promote cell proliferation, while anti-androgenic progestins do not. These findings can help make more informed choices in hormonal contraception.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Yingxue Bai, Marina Ludescher, Gereon Poschmann, Kai Stuehler, Martine Wyrich, Julia Oles, Andre Franken, Mahdi Rivandi, Anna Abramova, Florian Reinhardt, Eugen Ruckhaeberle, Dieter Niederacher, Tanja Fehm, Michael A. Cahill, Nadia Stamm, Hans Neubauer
Summary: Combined menopausal hormone therapy is associated with increased breast cancer risk in postmenopausal women. PGRMC1 plays a crucial role in breast cancer cell proliferation and may contribute to breast cancer progression through interaction with prohibitins.
Article
Oncology
Johanna Simin, Qing Liu, Xinchen Wang, Katja Fall, Cecilia Williams, Steven Callens, Lars Engstrand, Nele Brusselaers
Summary: The study found that past use of estrogen-only therapy (E-MHT) was associated with lower CRC-specific and all-cause mortality, while current E-MHT users aged 70+ had higher all-cause mortality. Current estrogen combined progestin therapy (EP-MHT) was associated with higher CRC-specific mortality in older women, but not with all-cause mortality.
Article
Biochemistry & Molecular Biology
Florian Le Billan, Julie Perrot, Elena Carceller, Simon Travers, Say Viengchareun, Peter Kolkhof, Marc Lombes, Jerome Fagart
Summary: The study analyzed the effects of two MRAs on the aldosterone-induced transcriptome in a human renal cell line, revealing the regulation of hundreds of genes by aldosterone and the quantitative efficiency of finerenone on certain aldosterone-induced genes. The data provides insights into the mechanisms of MR signaling pathway and potential therapeutic targets for renal dysfunction.
Article
Biochemistry & Molecular Biology
Meghan Cartwright, Renate Louw-du Toit, Donita Africander
Summary: This study reveals the differential agonist efficacies and potencies of various progestins via different densities of PR-A in the same model system. It also suggests that the effects of these progestins are specific to each progestin and dependent on the density of the receptor. These findings have important implications for contraception and menopausal hormone therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Micaela Sundell, Anna-Clara Spetz Holm, Mats Fredrikson, Mats Hammar, Mikael Hoffmann, Jan Brynhildsen
Summary: Oral menopausal hormone therapy increases the risk of pulmonary embolism, while transdermal administration does not. First ever users have the highest risk, but recurrent treatment is associated with lower risk.
Review
Obstetrics & Gynecology
Holly J. Pederson, Pelin Batur
Summary: This article discusses the challenges of addressing hormone needs in individuals at increased risk of breast cancer. The use of hormonal contraception in women is supported by observational and prospective studies, with additional benefits of reducing ovarian and endometrial cancer risk. Majority of data on menopausal hormone therapy in high-risk patients come from studies on BRCA1 and BRCA2 gene carriers who undergo early surgical menopause. Hormone therapy is shown to mitigate accelerated osteoporosis and cardiovascular disease in these patients without minimizing the benefits of risk-reducing surgery.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
Richard H. Cockrum, Jackie Soo, Sandra A. Ham, Kenneth S. Cohen, Shari G. Snow
Summary: This study evaluated the association between seven progestogens and incident acute venous thromboembolism (VTE) among women of reproductive age. Higher-dose progestogens, specifically norethindrone acetate and medroxyprogesterone acetate, were found to be significantly associated with increased odds of VTE. Further research on progestogen type, dose, and indication for use is warranted.
OBSTETRICS AND GYNECOLOGY
(2022)
Review
Oncology
JoAnn Pinkerton
Summary: Following the release of the Women's Health Initiative data, women began using compounded bioidentical hormone therapy (cBHT) believing it to be safer and more effective than traditional hormone therapy. New guidelines recommend government-approved hormone therapy for symptomatic healthy menopausal women under 60 years old or within 10 years of menopause. Government-approved hormone therapies similar to premenopausal hormones are available with extensive data on pharmacokinetics, safety, and efficacy. Non-Food and Drug Administration-approved cBHTs lack such data and should only be used for women with allergies or unavailable formulations. Pellet therapy with supraphysiologic hormone dosing raises safety concerns.
Review
Nanoscience & Nanotechnology
Namita Mahadik, Dwaipayan Bhattacharya, Akshaya Padmanabhan, Kalyani Sakhare, Kumar Pranav Narayan, Rajkumar Banerjee
Summary: Steroid hormone receptors, particularly the glucocorticoid receptor (GR), show potential as druggable targets for cancer treatment due to their aberrant expression patterns and context-specific regulation in cancer cells. Despite not fitting into the category of conventional cell surface receptors, efforts to develop SHR-targeted anticancer therapeutics, including nanodelivery systems and small molecules, are active in research.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Oncology
Lilah Khoja, Rachel Palmieri Weber, Penelope M. Webb, Susan J. Jordan, Aruna Muthukumar, Jenny Chang-Claude, Renee T. Fortner, Allan Jensen, Susanne K. Kjaer, Harvey Risch, Jennifer Anne Doherty, Holly R. Harris, Marc T. Goodman, Francesmary Modugno, Kirsten Moysich, Andrew Berchuck, Joellen M. Schildkraut, Daniel Cramer, Kathryn L. Terry, Hoda Anton-Culver, Argyrios Ziogas, Minh Tung Phung, Gillian E. Hanley, Anna H. Wu, Bhramar Mukherjee, Karen McLean, Kathleen Cho, Malcolm C. Pike, Celeste Leigh Pearce, Alice W. Lee
Summary: The study evaluated the association between hysterectomy and ovarian cancer, finding a complex relationship that is influenced by hormone therapy use and history of endometriosis. Adjustment for duration of hormone therapy use and endometriosis history is essential to fully understand the association between hysterectomy and ovarian cancer risk. The findings suggest that overall, hysterectomy is not a protective factor against ovarian cancer, but a potential inverse association exists for women with a history of endometriosis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
James R. Hilser, Jaana A. Hartiala, Intira Sriprasert, Naoko Kono, Zhiheng Cai, Roksana Karim, Joseph DeYoung, Wendy J. Mack, Howard N. Hodis, Hooman Allayee
Summary: The study found specific methylation differences in response to hormone therapy among women who were 10 or more years postmenopause. Further research is needed to determine the functional consequences of these changes on atherosclerosis progression and the protective effects of hormone therapy.
CLINICAL EPIGENETICS
(2022)
Article
Geriatrics & Gerontology
Cynthia A. Stuenkel
Summary: VMS in older women may persist into advanced age and increase cardiovascular disease risks. Nonhormonal treatment options are available for those who elect not to use, or are advised not to use, menopausal hormone therapies.
Editorial Material
Obstetrics & Gynecology
Renee Heffron, Sharon L. Achilles, Laneta J. Dorflinger, Janet P. Hapgood, James Kiarie, Chelsea B. Polis, Petrus S. Steyn
Article
Immunology
Michele Tomasicchio, Malika Davids, Anil Pooran, Grant Theron, Liezel Smith, Lynn Semple, Richard Meldau, Janet Patricia Hapgood, Keertan Dheda
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Microbiology
Sigcinile Dlamini, Michael Kuipa, Kim Enfield, Salndave Skosana, John G. Woodland, Johnson Mosoko Moliki, Alexis J. Bick, Zephne van der Spuy, Michelle F. Maritz, Chanel Avenant, Janet P. Hapgood
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Immunology
Janet P. Hapgood
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2020)
Article
Biochemistry & Molecular Biology
Kim Enfield, Meghan Cartwright, Renate Louw-du Toit, Chanel Avenant, Donita Africander, Janet P. Hapgood
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Kim Enfield, Sigcinile Dlamini, Chanel Avenant, Michael Kuipa, Janet P. Hapgood
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Pharmacology & Pharmacy
Alexis J. Bick, Renate Louw-du Toit, Salndave B. Skosana, Donita Africander, Janet P. Hapgood
Summary: This study discusses the impact of different forms of hormonal contraception and progestins on side effects, reproductive cancers, and susceptibility to infectious diseases. The research highlights the lack of study on progestins used in hormonal contraception and emphasizes the need for greater understanding of these topics.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Maleshigo Komane, Chanel Avenant, Renate Louw-du Toit, Donita J. Africander, Janet P. Hapgood
Summary: This study compared the GR activities of several progestins and found that MPA, ETG, and NES have stronger binding affinities to GR and exhibit transactivation and transrepression activities, while LNG and NET show little to no activity in transactivation models but have some transrepressive activity.
Review
Biochemistry & Molecular Biology
Alexis J. Bick, Salndave B. Skosana, Chanel Avenant, Janet P. Hapgood
Summary: Quantification of serum progestin levels in clinical contraceptive studies is crucial for understanding progestin pharmacokinetics and improving the accuracy of self-reported contraceptive use. Current methods vary widely and lack standardization, leading to potential overestimation of progestin levels. Inter-individual and inter-study variation in maximum progestin concentrations post-injection highlights the need for standardized quantification methods and sampling time.
Article
Immunology
Alexis J. Bick, Chanel Avenant, Michele Tomasicchio, Zephne van der Spuy, Janet P. Hapgood
Summary: Both luteal phase progesterone levels and the use of the progestin-only contraceptive depo-medroxyprogesterone acetate (DMPA-IM) have been linked to increased S/HIV acquisition. The mechanisms underlying these associations are not well understood. This study found that DMPA-IM increases HIV-1 infection in a different manner than luteal phase hormones, involving the glucocorticoid receptor and changes in CCR5 and CD69 expression.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kim Enfield, Chanel Avenant, Janet P. Hapgood
Summary: This study compares the transcriptional responses of six widely-used progestogens via each progesterone receptor isoform. The results show that progestogens exhibit progestogen-specific potencies and efficacies through both PR isoforms. In addition, the study reveals that progestogen responses via PR-A are more potent and less efficacious than those via PR-B, independent of PR protein levels.
Article
Cell Biology
Johnson M. Moliki, Tawanda J. Nhundu, Leo Maritz, Chanel Avenant, Janet P. Hapgood
Summary: The pro-inflammatory cytokine CCL20 can be regulated by glucocorticoids and progestins, as well as other pro-inflammatory mediators, and this regulation can impact immune function and disease outcomes.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Letter
Medicine, General & Internal
Janet P. Hapgood
Article
Multidisciplinary Sciences
Roslyn M. Ray, Michelle F. Maritz, Chanel Avenant, Michele Tomasicchio, Sigcinile Dlamini, Zephne van der Spuy, Janet P. Hapgood
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)