Article
Nutrition & Dietetics
Lidia Daimiel, Victor Mico, Laura Diez-Ricote, Paloma Ruiz-Valderrey, Geoffrey Istas, Ana Rodriguez-Mateos, Jose Maria Ordovas
Summary: This pilot study found that the consumption of beer and non-alcoholic beer can differently modulate the levels of cardiometabolic microRNAs in plasma and macrophages, with microRNAs related to inflammation showing opposite trends after beer consumption compared to non-alcoholic beer consumption.
Article
Biochemistry & Molecular Biology
Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Cristina Gomez, Jose M. Gamez, Henrik E. Poulsen, Josep A. Tur, Antoni Sureda
Summary: This study aimed to assess the effects of a 2-year nutritional and lifestyle intervention on oxidative and inflammatory status in individuals at high cardiovascular disease risk. The results showed a greater reduction in abdominal obesity, blood pressure, and triglyceride levels after the intervention. Furthermore, an improvement in oxidative stress and proinflammatory status was observed.
Review
Cell Biology
Hannah Hinkley, Daniel A. Counts, Elizabeth Voncanon, Michael Lacy
Summary: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques within arterial walls. T cells play a pivotal role in the pathogenesis of atherosclerosis in which they help orchestrate immune responses and contribute to plaque development and instability. This article discusses the recognition of atherosclerosis-related antigens that may trigger T cell activation and the roles of diverse subsets of T cells in atherosclerosis.
Article
Immunology
Luxsena Sukumaran, Ken M. Kunisaki, Nicholas Bakewell, Alan Winston, Patrick W. G. Mallon, Nicki Doyle, Jane Anderson, Marta Boffito, Lewis Haddow, Frank A. Post, Jaime H. Vera, Memory Sachikonye, Caroline A. Sabin
Summary: HIV patients have a higher risk of cardiovascular diseases, which may be attributed to inflammation and immune activation. Three distinct inflammatory profiles were identified, and their associations with cardiovascular disease risk were assessed. The results showed that HIV patients with gut/immune activation and neurovascular inflammation profiles had higher cardiovascular disease risk compared to those with relatively low inflammation.
Review
Biochemistry & Molecular Biology
Vittoria Cammisotto, Cristina Nocella, Simona Bartimoccia, Valerio Sanguigni, Davide Francomano, Sebastiano Sciarretta, Daniele Pastori, Mariangela Peruzzi, Elena Cavarretta, Alessandra D'Amico, Valentina Castellani, Giacomo Frati, Roberto Carnevale
Summary: Oxidative stress, an imbalance between ROS and antioxidant system, is a common feature of many human disorders such as cardiovascular disease. Risk factors like smoking, hypertension, hypercholesterolemia, diabetes, and obesity are associated with an increased risk of cardiovascular disease due to elevated oxidative stress burden. Studies on antioxidant supplementation for oxidative stress-associated cardiovascular diseases have shown mixed results, sparking debate on their preventive and therapeutic value.
Review
Immunology
Wei Yu, Iqra Ilyas, Xuerui Hu, Suowen Xu, Hui Yu
Summary: Paeoniflorin, a bioactive monomer extracted from P. lactiflora Pall., has shown anti-atherosclerosis effects by regulating inflammation and immune-related pathway dysfunction in vascular endothelial cells, smooth muscle cells, and other cells. It has the potential to be a promising therapeutic agent for the treatment of atherosclerosis and its complications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Brandon Tejada, Roby Joehanes, Shih-Jen Hwang, Tianxiao Huan, Chen Yao, Jennifer E. Ho, Daniel Levy
Summary: The study found that higher inflammation scores were associated with smoking, older age, higher BMI, systolic blood pressure, lipids, and glucose levels, as well as greater odds of hypertension and diabetes. Additionally, higher baseline scores were linked to increased risk of new-onset cardiovascular disease events and all-cause mortality.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Medicine, General & Internal
Daniel Harding, Ming H. A. Chong, Nishant Lahoti, Carola M. Bigogno, Roshni Prema, Saidi A. Mohiddin, Federica Marelli-Berg
Summary: Dilated cardiomyopathy is a heart disease with unknown causes and limited treatment options. Immune dysfunction is believed to play a significant role in its development and progression. Current treatment focuses on symptom management and reducing the risk of sudden cardiac death.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Alexios S. Antonopoulos, Andreas Angelopoulos, Paraskevi Papanikolaou, Spyridon Simantiris, Evangelos K. Oikonomou, Konstantinos Vamvakaris, Alkmini Koumpoura, Maria Farmaki, Marialena Trivella, Charalambos Vlachopoulos, Konstantinos Tsioufis, Charalambos Antoniades, Dimitris Tousoulis
Summary: This study systematically explores the added value of biomarkers of vascular inflammation for cardiovascular prognostication on top of clinical risk factors.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Physiology
Sandra Gegunde, Amparo Alfonso, Rebeca Alvarino, Nadia Perez-Fuentes, Jeremias Bayon-Lorenzo, Eva Alonso, Raymundo Ocaranza-Sanchez, Rosa Alba Abellas-Sequeiros, Melisa Santas-Alvarez, Mercedes R. Vieytes, Carlos Juanatey-Gonzalez, Luis M. Botana
Summary: This study revealed that serum levels of cyclophilin A and C are elevated in patients with coronary artery disease regardless of the presence of cardiovascular risk factors. On the other hand, cyclophilin B levels are increased in male patients with hypertension, type 2 diabetes, or high glucose levels. All three cyclophilins were significantly correlated with cardiovascular risk factors, with cyclophilin B specifically associated with type 2 diabetes. Multivariate analysis further demonstrated the predictive value of cyclophilin A and C in the presence of coronary artery disease, along with other cardiovascular risk factors. Additionally, high levels of cyclophilin B, combined with hypertension or dyslipidemia, increased the risk of coronary artery disease in male patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Timoteo Marchini, Sara Malchow, Lourdes Caceres, Abed Al Hadi El Rabih, Sophie Hansen, Timothy Mwinyella, Lisa Spiga, Sven Piepenburg, Hauke Horstmann, Tijani Olawale, Xiaowei Li, Lucia Sol Mitre, Mark Colin Gissler, Heiko Bugger, Andreas Zirlik, Timo Heidt, Ingo Hilgendorf, Peter Stachon, Constantin von Zur Muehlen, Christoph Bode, Dennis Wolf
Summary: Using a novel assay, this study found that circulating human ApoB auto-antibodies are associated with cardiovascular risk factors but not with the clinical appearance of atherosclerosis. This finding suggests that humoral immune responses against ApoB are shaped by cardiovascular risk factors rather than the disease itself. This tool could be helpful for immune-based risk stratification in clinical atherosclerosis in the future.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop S. V. Shah, Jim D. Davies, Abdulrahim R. Mulla, Kerrie Woods, Joe Omigie, Anoop Shah, Mark W. Thursz, Paul Elliott, Harry M. Hemmingway, Bryan Williams, Folkert Asselbergs, Michael O. O'Sullivan, Graham Lord, Adam P. Trickey, Jonathan A. C. Sterne, Dorian M. Haskard, Narbeh Melikian, Darrel Francis, Wolfgang S. Koenig, Ajay M. Shah, Rajesh Kharbanda, Divaka Perera, Riyaz Patel, Keith Channon, Jamil Mayet, Ramzi Khamis
Summary: This study aimed to investigate the prognostic value of mildly elevated hsCRP in patients with suspected ACS. The results showed a positive relationship between hsCRP levels and mortality, beyond the predictive value of troponin. This suggests the potential utility of hsCRP as a prognostic marker and in selecting patients for novel inflammation-targeting treatments.
Article
Immunology
Laura Atehortua, Mirza Baig, Jamie Morris, Sarah Trentman, W. Sean Davidson, Carl J. Fichtenbaum, Claire A. Chougnet
Summary: Memory regulatory T cells in HIV patients have lower numbers and reduced responsiveness to high density lipoproteins, which may contribute to increased risk of cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alwin de Jong, Rob C. M. de Jong, Erna A. Peters, Ramon Arens, J. Wouter Jukema, Margreet R. de Vries, Paul H. A. Quax
Summary: The study found that PCAF deficiency led to a decrease in circulating FoxP3(+) regulatory T cells, but did not affect systemic inflammation or macrophage differentiation in atherosclerotic lesions. This suggests that PCAF regulates atherosclerosis by modulating FoxP3(+) regulatory T cell differentiation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Letter
Cardiac & Cardiovascular Systems
James S. Floyd, Colleen M. Sitlani, Margaret F. Doyle, Matthew J. Feinstein, Nels C. Olson, Susan R. Heckbert, Sally A. Huber, Russell P. Tracy, Bruce M. Psaty, Joseph A. C. Delaney
Article
Pharmacology & Pharmacy
Roseanne Offiah, Laila Aboulatta, Payam Peymani, Basma Aloud, Kaarina Kowalec, Christine Leong, Joseph Delaney, Jamie Falk, Silvia Alessi-Severini, Sherif Eltonsy
Summary: This study compares the utilization patterns of prescribed NSAIDs and opioids between males and females in Manitoba, Canada during the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Immunology
Stephanie A. Ruderman, Robin M. Nance, Lydia N. Drumright, Bridget M. Whitney, Andrew W. Hahn, Jimmy Ma, Lara Haidar, Sherif Eltonsy, Kenneth H. Mayer, Joseph J. Eron, Meredith Greene, William C. Mathews, Allison Webel, Michael S. Saag, Amanda L. Willig, Charles Kamen, Mary Mccaul, Geetanjali Chander, Edward Cachay, William B. Lober, Chintan Pandya, Francisco Cartujano-Barrera, Stephen B. Kritchevsky, Steven N. Austad, Alan Landay, Mari M. Kitahata, Heidi M. Crane, Joseph A. C. Delaney
Summary: This study developed a simple tool to assess the frailty risk among HIV patients and to screen high-risk individuals for appropriate clinical interventions.
Article
Immunology
Kristina M. Crothers, Robin M. Nance, Bridget N. Whitney, Barbara R. Harding, Susan J. Heckbert, Matthew C. Budoff, William Mathews, Laura R. Bamford, Edward J. Cachay, Joseph Eron, Sonia D. Napravnik, Richard C. Moore, Jeanne Keruly, Amanda Willig, Greer J. Burkholder, Matthew S. Feinstein, Michael M. Saag, Mari M. Kitahata, Heidi Crane, Joseph A. C. Delaney, CNICS
Summary: This study utilized data from a multicenter observational study to investigate the relationship between chronic obstructive pulmonary disease (COPD) and cardiovascular disease in people with HIV. The results showed that COPD is associated with an increased risk of myocardial infarction (MI), including both type 1 (T1MI) and type 2 (T2MI). This suggests the need for further research on strategies to prevent MI in individuals with COPD.
Article
Immunology
Andrew W. Hahn, Stephanie A. Ruderman, Robin M. Nance, Bridget W. Whitney, Sherif Eltonsy, Lara Haidar, Joseph A. C. Delaney, Lydia N. Drumright, Jimmy Ma, Kenneth H. Mayer, Conall O. 'Cleirigh, Sonia Napravnik, Joseph J. Eron, Katerina Christopoulos, Laura Bamford, Edward Cachay, Jeffrey M. Jacobson, Amanda Willig, Karen Cropsey, Geetanjali Chander, Heidi M. Crane, Rob J. Fredericksen
Summary: This study examined demographics, patterns of use, depression, and panic symptoms associated with vaporized nicotine (VN) and combustible cigarette (CC) use among people with HIV (PWH). The results showed that VN users were younger, had a higher proportion of White individuals, and were more likely to also use CC. Former CC users had a higher frequency of VN use. PWH using VN had higher rates of depression and panic disorder. Further research is needed to understand the role of VN in self-medication and cigarette substitution.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Nursing
Stephanie A. Ruderman, Allison R. Webel, Amanda L. Willig, Lydia N. Drumright, Annette L. Fitzpatrick, Michelle C. Odden, John D. Cleveland, Greer Burkholder, Christine H. Davey, Julia Fleming, Thomas W. Buford, Raymond Jones, Robin M. Nance, Bridget M. Whitney, L. Sarah Mixson, Andrew W. Hahn, Kenneth H. Mayer, Meredith Greene, Michael S. Saag, Charles Kamen, Chintan Pandya, William B. Lober, Mari M. Kitahata, Paul K. Crane, Heidi M. Crane, Joseph A. C. Delaney
Summary: Modifications to Fried's frailty phenotype (FFP) are common. We evaluated a self-reported modified frailty phenotype (Mod-FP) used among people with HIV (PWH). The Mod-FP has good performance in measuring frailty among PWH and is reasonable to use when the gold standards of observed assessments (i.e., weakness and slowness) are not feasible.
JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
(2023)
Article
Public, Environmental & Occupational Health
Sari L. Reisner, Bridget M. Whitney, Heidi M. Crane, Kenneth H. Mayer, Chris Grasso, Robin M. Nance, Tonia Poteat, W. Chris Mathews, Katerina Christopoulos, Michael J. Mugavero, Geetanjali Chander, Joseph J. Eron, Mari M. Kitahata, Joseph A. C. Delaney, Rob J. Fredericksen
Summary: A study conducted in a U.S. HIV care cohort revealed differences in HIV health outcomes and co-morbidities between transgender women (TW) and cisgender men and women (CM, CW).
Article
Endocrinology & Metabolism
Nels C. Olson, Margaret F. Doyle, Petra Buzkova, Sally A. Huber, Ian H. de Boer, Colleen M. Sitlani, Russell P. Tracy, Bruce M. Psaty, Kenneth J. Mukamal, Joseph A. Delaney
Summary: The relationship between senescent lymphocytes and diabetes is uncertain. This study found no significant associations between frequencies of naive, memory, and senescent T cells and memory B cells and the risk of incident diabetes in older adults.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Article
Infectious Diseases
Lydia N. Drumright, Robin M. Nance, Stephanie A. Ruderman, Jimmy Ma, Bridget M. Whitney, Andrew Hahn, Rob J. Fredericksen, Brandon Luu, William B. Lober, Richard D. Moore, Matthew J. Budoff, Jeanne C. Keruly, Katerina Christopoulos, Sarah Puryear, Amanda Willig, Karen Cropsey, William C. Mathews, Edward Cachay, Laura Bamford, Joseph J. Eron, Sonia Napravnik, Kenneth H. Mayer, Conall O'Cleirigh, Mary E. Mccaul, Geetanjali Chander, Matthew J. Feinstein, Michael S. Saag, Mari M. Kitahata, Susan R. Heckbert, Heidi M. Crane, Joseph A. C. Delaney
Summary: People with HIV have a higher risk of myocardial infarction, with a greater proportion of type 2 MI due to oxygen demand-supply mismatch compared with type 1 resulting from atherothrombotic plaque disruption. HIV-positive individuals report a higher prevalence of cigarette and alcohol use. However, the impact of smoking and alcohol consumption on MI type among people living with HIV is not well studied.
Article
Clinical Neurology
Rizwan Kalani, Traci M. Bartz, Bruce M. Psaty, Mitchell S. V. Elkind, James S. Floyd, Robert E. Gerszten, Ali Shojaie, Susan R. Heckbert, Joshua C. Bis, Thomas R. Austin, David L. Tirschwell, Joseph A. C. Delaney, W. T. Longstreth
Summary: Plasma proteomics study in a cohort of older adults identified N-terminal probrain natriuretic peptide (NTproBNP) and macrophage metalloelastase (MMP12) as independent risk factors for ischemic stroke (IS). Additionally, associations between plasma proteins and specific types of IS were observed, as well as a novel protein associated with IS risk in individuals with left atrial dysfunction.
Article
Health Policy & Services
R. J. Fredericksen, E. Fitzsimmons, L. N. Drumright, S. Loo, S. Dougherty, S. Brown, J. Pearce, R. M. Nance, B. M. Whitney, S. Ruderman, C. O'Cleirigh, K. Cropsey, K. H. Mayer, M. J. Mugavero, J. A. C. Delaney, H. M. Crane, A. Hahn
Summary: Evidence suggests limited efficacy of vaporized nicotine (VN), such as e-cigarettes, in aiding tobacco cessation. People with HIV (PWH) have higher smoking rates and greater morbidity, emphasizing the need for effective tobacco cessation tools. Interviews with PWH revealed limited understanding of VN's content and health effects, and its unsuccessful replication of the desired effects of smoking tobacco cigarettes (TC).
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Pediatrics
Laila Aboulatta, Kaarina Kowalec, Christine Leong, Joseph A. Delaney, Jamie Falk, Silvia Alessi-Severini, Dan Chateau, Qier Tan, Katherine Kearns, Christina Raimondi, Christine Vaccaro, Alekhya Lavu, Lara Haidar, Payam Peymani, Sherif Eltonsy
Summary: This study aimed to assess the changes in preterm birth and stillbirth rates before and during the COVID-19 pandemic, and evaluate the potential effect of socioeconomic status (SES). The study used administrative health databases from Manitoba, Canada, and found that the risk of preterm birth increased by 7.7% and stillbirth rates increased by 33% during the pandemic. Socioeconomic status had an impact on preterm birth rates.
BMJ PAEDIATRICS OPEN
(2023)
Article
Immunology
Stephanie A. Ruderman, Michelle C. Odden, Allison R. Webel, Annette L. Fitzpatrick, Paul K. Crane, Robin M. Nance, Lydia N. Drumright, Bridget M. Whitney, Lyndsey Sarah Mixson, Jimmy Ma, Amanda L. Willig, Lara Haidar, Sherif Eltonsy, Kenneth H. Mayer, Conall O'Cleirigh, Karen L. Cropsey, Joseph J. Eron, Sonia Napravnik, Meredith Greene, Mary McCaul, Geetanjali Chander, Edward Cachay, William B. Lober, Stephen B. Kritchevsky, Steven Austad, Alan Landay, Chintan Pandya, Francisco Cartujano-Barrera, Michael S. Saag, Charles Kamen, Andrew W. Hahn, Mari M. Kitahata, Joseph A. C. Delaney, Heidi M. Crane
Summary: smoking status and duration are associated with incident and worsening frailty among people with HIV.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)