Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling

The PHLPP2 phosphatase is a druggable driver of prostate cancer progression

(2019) Dawid G. Nowak et al.   JOURNAL OF CELL BIOLOGY

SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

(2019) Linzhang Huang et al.   NATURE

Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods

(2019) Emrah Eroglu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch2 and Proteomic Signatures in Mouse Neointimal Lesion FormationHighlights

(2018) Sarah M. Peterson et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SHP2 protects endothelial cell barrier through suppressing VE-cadherin internalization regulated by MET-ARF1

(2018) Jie Zhang et al.   FASEB JOURNAL

Cytochrome P450 1B1 Is Critical for Neointimal Growth in Wire‐Injured Carotid Artery of Male Mice

(2018) Kamalika Mukherjee et al.   Journal of the American Heart Association

Endothelial-Specific Cre Mouse Models

(2018) Sophie Payne et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Enigma proteins regulate YAP mechanotransduction

(2018) Ahmed Elbediwy et al.   JOURNAL OF CELL SCIENCE

PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

(2018) Qiuhua Yang et al.   Nature Communications

Thirty Years of Saying NO

(2016) Paul M. Vanhoutte et al.   CIRCULATION RESEARCH

Loss of MicroRNA-17∼92 in Smooth Muscle Cells Attenuates Experimental Pulmonary Hypertension via Induction of PDZ and LIM Domain 5

(2015) Tianji Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5

(2015) Yi Yan et al.   Nature Communications

Regulation of eNOS Enzyme Activity by Posttranslational Modification

(2014) Elke Heiss et al.   CURRENT PHARMACEUTICAL DESIGN

Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis

(2014) Jessilyn Dunn et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of an oral allosteric AKT inhibitor (MK-2206) on human nasopharyngeal cancer in vitro and in vivo

(2014) Yuanyuan Zhao et al.   Drug Design Development and Therapy

Cypher/ZASP Is a Novel A-kinase Anchoring Protein

(2013) Changsong Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of two genes potentially associated in iron-heme homeostasis in human carotid plaque using microarray analysis

(2013) Hanène Ayari et al.   JOURNAL OF BIOSCIENCES

MicroRNAs of the miR-17∼92 family are critical regulators of TFH differentiation

(2013) Seung Goo Kang et al.   NATURE IMMUNOLOGY

NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1

(2013) Y Yu et al.   ONCOGENE

Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation

(2012) Changjun Yang et al.   CARDIOVASCULAR RESEARCH

Suppression of survival signalling pathways by the phosphatase PHLPP

(2012) Audrey K. O’Neill et al.   FEBS Journal

LIM domains regulate protein kinase C activity: A novel molecular function

(2011) Andrés D. Maturana et al.   CELLULAR SIGNALLING

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

(2011) J R Molina et al.   ONCOGENE

Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

(2011) Y. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splice variants of Enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy

(2010) Tomoko Yamazaki et al.   CARDIOVASCULAR RESEARCH

Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy

(2010) Hongqiang Cheng et al.   CIRCULATION RESEARCH

Mst1 Is an Interacting Protein that Mediates PHLPPs' Induced Apoptosis

(2010) Meng Qiao et al.   MOLECULAR CELL

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

(2009) Huadong Pei et al.   CANCER CELL

Contribution of Insulin and Akt1 Signaling to Endothelial Nitric Oxide Synthase in the Regulation of Endothelial Function and Blood Pressure

(2009) J. David Symons et al.   CIRCULATION RESEARCH

AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633

(2009) Zhen Chen et al.   CIRCULATION RESEARCH

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

(2009) You-Yang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

ALP/Enigma PDZ-LIM Domain Proteins in the Heart

(2009) M. Zheng et al.   Journal of Molecular Cell Biology

Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study

(2009) Sara Hägg et al.   PLoS Genetics

Enigma homolog 1 scaffolds protein kinase D1 to regulate the activity of the cardiac L-type voltage-gated calcium channel

(2008) Andrés D. Maturana et al.   CARDIOVASCULAR RESEARCH

Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation

(2008) Kimio Satoh et al.   CIRCULATION

Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis

(2008) J Liu et al.   ONCOGENE