Article
Chemistry, Physical
Murat Yigit, Nihat Sireci, Selami Guenal, Muhittin Onderci, Namik Ozdemir, Ali Arinc, Beyhan Yigit, Ismail Ozdemir
Summary: A series of new silyl-substituted benzimidazolium salts were synthesized and characterized. The crystal structure of 2c was determined by single-crystal X-ray diffraction. The synthesized compounds showed effective antibacterial activity against various bacterial strains and yeast strains.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Marta Malinowska, Diana Sawicka, Katarzyna Niemirowicz-Laskowska, Przemyslaw Wielgat, Halina Car, Tomasz Hauschild, Agnieszka Hryniewicka
Summary: The study found that newly synthesized imidazolium salts showed excellent activity against various pathogenic fungi and bacteria, with a broad spectrum of compatibility, making them universal antifungal agents. Initial safety assessments revealed no toxicity at effective concentrations against pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Hryniewicka, Katarzyna Niemirowicz-Laskowska, Przemyslaw Wielgat, Halina Car, Tomasz Hauschild, Jacek W. Morzycki
Summary: The novel dehydroepiandrosterone-derived imidazolium salts exhibit high antimicrobial activity against Gram-positive bacteria and Candida albicans, with good compatibility with host cells. Additionally, these compounds have immunoprotective properties.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jon Andrade del Olmo, Leyre Perez-Alvarez, Miguel Angel Pacha-Olivenza, Leire Ruiz-Rubio, Oihane Gartziandia, Jose Luis Vilas-Vilela, Jose Maria Alonso
Summary: Different polymeric antibacterial coatings were developed and analyzed for Ti6Al4V surface covering in this study, showing good cytocompatibility and antibacterial properties, which confirms their effectiveness against bacterial infections for future applications in protecting biomedical implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Subhankar Sarkar, Rana Chatterjee, Anindita Mukherjee, Debosmita Mukherjee, Narayan Chandra Mandal, Sachinta Mahato, Sougata Santra, Grigory Zyryanov, Adinath Majee
Summary: The use of imidazolium zwitterionic molten salt as an organocatalyst for ball-milling synthesis of 4-hydroxy-3-thiomethylcoumarin derivatives has shown to be efficient and convenient. The method offers mild conditions, wide substrate scope, and good scalability.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Hongying Tang, David Aili, Kang Geng, Jian Gao, Qingfeng Li, Nanwen Li
Summary: Polymers containing organic cations are promising materials for high temperature polymer electrolyte membranes due to their high PA retention and wider operation temperature range. However, the stability of these organic cations needs further investigation. By designing and preparing model cations, assessing their stability, and using a blend membrane with PBI and PA, significant progress has been made in developing durable high-performance HT-PEMs for green energy conversion.
JOURNAL OF POWER SOURCES
(2021)
Article
Chemistry, Organic
Ismat Nawaz, Muqadas Bashir, Rahman Shah Zaib Saleem, Ghayoor Abbas Chotana
Summary: This review focuses on the utilization and transformation of N-sulfonyl functionalized imidazolium and benzimidazolium salts as reagents for transferring functional groups onto organic molecules. The different classifications of these salts based on the functional groups they transfer are discussed, and their importance in biomedical and materials science is highlighted.
TETRAHEDRON LETTERS
(2023)
Article
Engineering, Environmental
Bo Liu, Jianghua Li, Zhongtian Zhang, James D. Roland, Bruce P. Lee
Summary: This study presents a novel hydrogel with pH responsive antibacterial activity. The hydrogel contains a pH responsive and reversible catechol-boronate linkage, which exhibits antimicrobial property under acidic conditions and becomes non-cytotoxic under basic conditions. The hydrogel can recover its antibacterial property when exposed to acidic pH. The strategy using catechol-Cl and phenylboronic acid provides a new approach for designing hydrogels with pH responsive antibacterial activity and reduced cytotoxicity.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Organic
Xiaofei Yi, Zongxiang Zhao, Manman Wang, Wenquan Yu, Junbiao Chang
Summary: In this study, an intramolecular sp3 C-H amination reaction of aniline derivatives was established using molecular iodine under transition-metal-free conditions. The reaction yielded 1,2-fused or 1,2-disubstituted benzimidazoles in an efficient and scalable fashion. This synthetic process also produced novel benzimidazolium frameworks and bioactive compounds.
Review
Biochemistry & Molecular Biology
Tianxi Li, Lulu Li, Fangyuan Du, Lei Sun, Jichao Shi, Miao Long, Zeliang Chen
Summary: This review focuses on antifungal peptides isolated from various microorganisms, outlining their antifungal activity, toxic effects, and mechanisms of action, as well as common solutions to mitigate their toxicity. This work serves as a useful reference for further clinical research and the development of safe antifungal drugs with high efficiencies and broad application spectra.
Article
Chemistry, Physical
Yun Ran, Yong Liu, Hong Sun, Hanfang Zhang, Haixia Dong, Yaoguo Yang, Ning Zhao, Jian Xu
Summary: A simple surface modification method was reported to improve the chemical stability and antibacterial performance of Cu2O nanoparticles, leading to potential applications in the preparation of antibacterial membranes.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Carlos J. Carrasco, Francisco Montilla, Eleuterio Alvarez, Agustin Galindo, Maria Perez-Aranda, Eloisa Pajuelo, Ana Alcudia
Summary: In this study, novel one-dimensional or two-dimensional coordination polymers were synthesized and their antimicrobial properties were evaluated. The results showed that complexes 2a and 2b' exhibited the best antimicrobial activity against the tested pathogens.
DALTON TRANSACTIONS
(2022)
Article
Microbiology
Ana Gomes, Lucinda J. Bessa, Iva Fernandes, Luisa Aguiar, Ricardo Ferraz, Claudia Monteiro, M. Cristina L. Martins, Nuno Mateus, Paula Gameiro, Catia Teixeira, Paula Gomes
Summary: This study presents novel ionic liquid/PP4 conjugates with potent antibacterial and collagenesis-inducing effects. These conjugates exhibit activity against multidrug-resistant bacterial strains and both Gram-positive and Gram-negative bacteria, as well as antimicrobial activity in simulated wound fluid. Additionally, they demonstrate comparable or stronger collagen formation effects compared to Matrixyl. These findings support the development of IL-KTTKS conjugates as promising topical treatments for complicated skin and soft tissue infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Ashley L. Cunningham, Orhi Esarte Palomero, Bradley J. Voss, M. Stephen Trent, Bryan W. Davies
Summary: Otilonium bromide, a poorly absorbed oral medication used for irritable bowel syndrome, has been found to have broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. This suggests that otilonium bromide could be a new option for intestinal antimicrobial therapy targeting enteric pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Nanoscience & Nanotechnology
Hamdi Ben Halima, Thibaut Zwingelstein, Vincent Humblot, Boris Lakard, Lydie Viau
Summary: A strategy was developed to prepare antibacterial surfaces by electropolymerization of a pyrrole-functionalized imidazolium ionic liquid bearing a halometallate anion. The antibacterial properties of the monomer [PyC(8)MIm]Br-ZnCl2 were evaluated and the films obtained by incorporation of [PyC(8)MIm]Br-ZnCl2 showed excellent antibacterial properties. The antibacterial activities of the different PPy films were determined both by the halo inhibition method and by the colony forming units (CFUs) counting method over time.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Namik Ozdemir, Murat Kaloglu, Nazan Kaloglu, Nevin Gurbuz, Ismail Ozdemir
Summary: A newly synthesized organic salt and its complexes were characterized by a combination of experimental and computational methods, revealing high kinetic stability of the compounds.
INORGANIC AND NANO-METAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Murat Kaloglu, Nazan Kaloglu, Selami Gunal, Ismail Ozdemir
Summary: N-Heterocyclic carbene-based silver complexes (Ag-NHCs) are widely used in medicinal and pharmaceutical chemistry research due to their low toxicity. In this study, ten Ag-NHC complexes containing benzimidazol-2-ylidene ligand were synthesized and showed effective antimicrobial activity against microorganisms, making them potential metallopharmaceutical agents.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Dilek Turker, Elvan Ustun, Selami Gunal, Hatice Yildiz, Serpil D. Dusunceli, Ismail Ozdemir
Summary: New N-heterocyclic carbene precursors and silver-NHC complexes were synthesized and characterized, showing promising antibacterial activities against standard bacterial and fungal strains. The compounds were also analyzed using density functional theory (DFT)/time-dependent DFT and docking methods.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Medicinal
Murat Yigit, Yeliz Demir, Duygu Barut Celepci, Tugba Taskin-Tok, Ali Arinc, Beyhan Yigit, Muhittin Aygun, Ismail Ozdemir, Ilhami Gulcin
Summary: A series of new imidazolium salts were successfully synthesized and their structures were identified using various techniques. The experimental results showed that these imidazolium salts exhibited strong inhibition abilities, which are of great significance for the treatment of Alzheimer's disease, epilepsy, glaucoma, and leukemia.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Multidisciplinary
Serpil Demir Dusunceli, Mehmet Hanifi Sahan, Murat Kaloglu, Elvan Ustun, Ismail Ozdemir
Summary: In this study, a series of quinoxaline-bridged bis(benzimidazolium) salts were synthesized and their photophysical properties were investigated. The salts exhibited moderate-to-high activity in the palladium-catalyzed cross-coupling reactions.
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2022)
Article
Chemistry, Inorganic & Nuclear
Mert Olgun Karatas, Tuba Keskin, Namik Ozdemir, Hasan Kucukbay, Suat Tekin, Ahmet Mansur, Selami Gunal, Suleyman Sandal
Summary: In this study, Ag, Rh, and Ir complexes of a silyl-substituted NHC ligand were synthesized and their biological properties were investigated. The results showed that these complexes exhibited comparable or better cytotoxicity against cancer cells and antimicrobial activity compared to standard drugs.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Emine O. Karaca, Zeynebe Bingol, Nevin Gurbuz, Ismail Ozdemir, Ilhami Gulcin
Summary: A series of vinyl functionalized 5,6-dimethylbenzimidazolium salts were synthesized and evaluated for their inhibition ability against various enzymes. The compounds showed effective inhibition profiles and may contribute to the development of new drugs for global disorders.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Zeyneb Belhi, Huseyin Karci, Muhammet Dundar, Nevin Gurbuz, Ilknur Ozdemir, Ahmet Koc, Abdelkrim Cheriti, Ismail Ozdemir
Summary: This study synthesized and characterized 1,3-dialkyl-5,6-dimethyl-benzimidazolium salts and their silver complexes. Four novel silver(I)-N-heterocyclic carbene complexes were synthesized and characterized. The antimicrobial and antitumor activities of the synthesized compounds were evaluated in vitro, and the results showed that silver(I)-NHC complexes exhibit antimicrobial activity and certain complexes possess broad-spectrum antimicrobial activity. The synthesized compounds were also evaluated for their anticancer properties and compared with cisplatin.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ibrahim S. S. Al Nasr, Waleed S. S. Koko, Tariq A. A. Khan, Nevin Gurbuz, Ismail Ozdemir, Naceur Hamdi
Summary: A series of RuCl2(p-cymene)(NHC) complexes were synthesized and their structures were determined. These complexes exhibited potent enzyme inhibitory, antioxidant, antimicrobial, anticancer, and antiparasitic properties. Among them, complex 3d showed the highest inhibitory activity against AchE, excellent antimicrobial activity, and promising cytotoxic and antiparasitic activities. Further research on its mode of action and in vivo evaluation is recommended.
Article
Chemistry, Physical
Chaymae Bourhou, Hind Benouda, Reda Bellaouchi, Mohammed Merzouki, Elmehdi Fraj, Tarik Harit, Allal Challioui, Abdeslam Asehraou, Rachid Touzani, Ismail Ozdemir, Boufelja Bouammali
Summary: This study involves the synthesis of novel Bis(arylidene-2-[(tetrazol-5-yl)]alkane derivatives and their evaluation for antibacterial and antifungal activities. The compounds showed moderate yields and their structures were determined through spectroscopic analyses. In vitro testing revealed antimicrobial properties against various bacterial and fungal strains. Docking study further confirmed the interactions of the compounds with the active site in Staphylococcus aureus.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Namik Ozdemir, Funda Dogan Karabekmez, Emine Ozge Karaca, Nevin Gurbuz, Ismail Ozdemir
Summary: A new N-coordinated benzimidazole ruthenium(II) complex was successfully synthesized and fully characterized using FT-IR, 1H and 13C NMR spectroscopy. The molecular structure was confirmed through X-ray crystallography. Theoretical structure and spectroscopic data were obtained using density functional theory and compared with experimental results. The complex exhibited activity in the N-alkylation of aromatic amines with arylmethyl alcohols under neat conditions in the presence of KOBut. (c) 2023 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Erdem Atalay Cetinkaya, Ahmet Koc, Hatice Kubra Koc, Hande Karabiyik, Hasan Karabiyik, Elvan Ustun, Ismail Ozdemir
Summary: This study synthesized six new 5,6-dimethylbenzimidazolium ligand precursors functionalized by using 2-naphthylmethyl and their silver complexes. The molecules were characterized by various spectroscopic techniques. One silver complex was found to be dimeric through X-ray crystallography analysis. Some of the synthesized compounds exhibited significant antimicrobial activity. In addition, molecular docking analysis was performed for all optimized ligands and complexes.
Article
Chemistry, Medicinal
Elvan Ustun, Neslihan Sahin, Ilknur Ozdemir, Selami Gunal, Nevin Gurbuez, Ismail Ozdemir, David Semeril
Summary: Two series of silver(I) nitrate complexes, bis(1-alkylbenzimidazole)silver(I) nitrate and bis(1-alkyl-5,6-dimethylbenzimidazole)silver(I) nitrate, were synthesized and characterized. These complexes showed moderate antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as good antifungal activity against Candida albicans and Candida glabrata. Molecular docking and reactivity descriptor calculations were also performed.
ARCHIV DER PHARMAZIE
(2023)
