Article
Biochemistry & Molecular Biology
Francisco J. Corpas
Summary: This article discusses the significant change in the perception of hydrogen sulfide (H2S) in living organisms over the past three decades. Once considered toxic, H2S is now recognized as a multifunctional signaling molecule involved in various physiological processes in animal and plant cells. The article introduces a series of research papers highlighting the relevance of H2S in plant and mammalian research, as well as future directions for investigations.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Eugenia Piragine, Valentina Citi, Kim Lawson, Vincenzo Calderone, Alma Martelli
Summary: After its discovery in the central nervous system, the physiological role of H2S has been extensively studied, especially in the control of vascular tone. Natural molecules derived from plants like garlic and rocket have shown slow H2S-releasing properties and potential as tools for hypertension management.
Review
Chemistry, Medicinal
Eugenia Piragine, Vincenzo Calderone
Summary: Type 2 diabetes is a common age-related metabolic disorder with increasing interest in the pharmacological modulation of endogenous H2S-system due to its role in pathogenesis and prevention of complications. H2S-releasing molecules could be a promising strategy in clinical management and prevention of macro- and micro-vascular complications associated with hyperglycemia, while naturally occurring H2S-donors from dietary organosulfur compounds have potential therapeutic benefits.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Pawan Faris, Sharon Negri, Delia Faris, Francesca Scolari, Daniela Montagna, Francesco Moccia
Summary: Hydrogen sulfide (H2S) is an endogenous gaseous molecule studied for its toxicity, but recent research has shown its relevance as a signaling molecule with potential implications in clinical disorders and cancer. This article provides an overview of H2S's properties, enzymatic pathways, and role as a signaling molecule. It also discusses the potential of H2S-releasing agents as therapeutic tools, the paradoxical role of H2S in tumor biology, and the use of H2S levels as cancer biomarkers. Additionally, it describes the preclinical applications of H2S-releasing compounds in assessing their anti-cancer impact.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Hideo Kimura
Summary: Initially considered a toxic gas, further research has shown that H2S has physiological roles and can act as a signaling molecule, working in synergy with NO to relax vascular smooth muscle. H2Sn, produced by 3MST, regulate the activity of ion channels and enzymes, and even affect tumor growth.
Article
Chemistry, Multidisciplinary
Xianghua Wu, Yuxun Lu, Bo Liu, Yu Chen, Junfeng Zhang, Ying Zhou
Summary: Hydrogen sulfide (H2S) serves as a crucial signaling molecule in biological systems and can be utilized as a trigger for new drug release, benefiting cancer bio-imaging and therapy. The designed fluorescent theranostic prodrug compound can specifically react with H2S, releasing active therapeutic components, showing potential for cancer treatment.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Mrinmoy Maiti, Shin A. Yoon, Yujin Cha, K. K. Athul, Sankarprasad Bhuniya, Min Hee Lee
Summary: The endogenous H2S-driven theranostic H2S-Gem selectively activates and releases active gemcitabine in cancer cells, while producing fluorescence signals. Compared to the mother chemotherapeutic gemcitabine, H2S-Gem shows better inhibition of cancer cell growth and provides a unique approach for tracking and delivering chemotherapeutic agents to tumor areas without the need for tumor-directive ligands.
CHEMICAL COMMUNICATIONS
(2021)
Editorial Material
Endocrinology & Metabolism
Emeline Joulia, Christian M. Metallo
Summary: Methionine restriction influences tumour growth and ageing processes by affecting various metabolic processes. Ji et al. demonstrate that methionine restriction decreases the production of hydrogen sulfide (H2S), which impairs H2S-mediated immune signaling and leads to increased cancer progression in immunocompetent mice.
Article
Chemistry, Analytical
Junbin Li, Ying Zhou, Lifei Song, Sheng Yang, Qianqian Wang, Yibo Zhou, Xiao-Bing Zhang, Zhihe Qing, Ronghua Yang
Summary: In this study, a nanobeacon sensitive to hydrogen sulfide (H2S) was developed for monitoring in situ antioxidant fluctuation during epilepsy. The nanobeacon revealed that H2S levels were elevated during mild epilepsy but significantly suppressed during severe epilepsy. This research provides important insights into the pathology of epilepsy.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bingchen Yu, Ting Kang, Yuan Xu, Yiqing Liu, Yaru Ma, Bowen Ke
Summary: Persulfide prodrugs, such as hydrogen persulfide (H2S2), show increased pharmacological activities and reduced toxicity compared to hydrogen sulfide (H2S), indicating their potential as better therapeutic options.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Christopher H. Switzer, Jon M. Fukuto
Summary: It has been found that hydrogen sulfide, hydropersulfides, and other polysulfide species are biochemically interconnected. The unique chemistry of hydropersulfides suggests that they may possess protective properties to help cells withstand oxidative and electrophilic stress. However, hydropersulfides and polysulfides can also generate oxidative and electrophilic stress as well. This article discusses the chemistry, biochemistry, and physiological implications of hydropersulfides and polysulfides, particularly their potential protective properties against various stresses and their role as stressors or signaling agents.
Article
Chemistry, Multidisciplinary
Yafu Wang, Xiaoli Zhao, Yuehua Chen, Tony D. James, Ge Wang, Hua Zhang
Summary: Naphthalimide-based fluorescent probes with dual locked fluorescence were developed. These probes demonstrated a highly sensitive off-on fluorescence response by synergistic changes of the molecular structure and conformation in the presence of H2S and DNA. They were capable of monitoring DNA damage and evaluating apoptosis induced by H2S in living cells.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mark R. Hellmich, Celia Chao, Katalin Modis, Ye Ding, John R. Zatarain, Ketan Thanki, Manjit Maskey, Nadiya Druzhyna, Ashley A. Untereiner, Akbar Ahmad, Yu Xue, Haiying Chen, William K. Russell, Jianmei Wang, Jia Zhou, Csaba Szabo
Summary: The upregulation of CBS in cancer cells has been identified as a tumor-promoting factor, leading to the synthesis of a novel CBS-targeting prodrug YD0251 with higher efficacy in inhibiting tumor growth compared to the prototypical CBS inhibitor AOAA. The prodrug was successful in suppressing tumor growth in vivo with low toxicity, and a potential plasma marker for CBS-expressing tumors was identified for potential future theranostic applications to match CBS inhibitor therapy with high-CBS expressors.
Editorial Material
Plant Sciences
Jian Chen, Heng Zhou, Yanjie Xie
Summary: Research shows that hydrogen sulfide signaling regulates plant responses to adverse conditions by impacting persulfidation and phosphorylation of proteins, modulating the coordination of abscisic acid and H2S signaling in drought responses.
TRENDS IN PLANT SCIENCE
(2021)
Article
Chemistry, Applied
Qikai Ju, Zhen Qiao, Ningning Wei, Yanru Zhang
Summary: In this study, a near-infrared fluorescent probe DCM-NBD is introduced, which shows super-fast response to H2S and has the potential for biological imaging.
Article
Cardiac & Cardiovascular Systems
Erifili Venieri, Constantina Aggeli, Aris Anastasakis, Helen Sambatakou, Christodoulos Stefanadis, Dimitrios Tousoulis
Summary: This study assessed the mitral valve in HCM patients and found that patients with and without obstruction share some common anatomic features, but those with obstruction have unique characteristics that may contribute to LVOT obstruction.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Letter
Medicine, General & Internal
Ioannis Doundoulakis, Dimitris Tsiachris, Konstantinos A. Gatzoulis, Christodoulos Stefanadis, Konstantinos Tsioufis
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Peripheral Vascular Disease
Shane A. Phillips, Kendra Osborn, Chueh-Lung Hwang, Ahmad Sabbahi, Mariann R. Piano
Summary: Oxidative stress is implicated in the development of many ethanol-induced pathologies, contributing to endothelial dysfunction and cardiovascular diseases such as hypertension. Ethanol consumption may alter vascular cell function and microvascular function, increasing the risk for hypertension. Data from human investigations have shown an association between alcohol consumption, changes in blood pressure, and hypertension risk.
CURRENT HYPERTENSION REVIEWS
(2021)