Journal
ANTICANCER RESEARCH
Volume 40, Issue 4, Pages 1883-1890Publisher
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.14142
Keywords
Breast cancer; neoadjuvant chemotherapy; tumor-infiltrating lymphocyte
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Funding
- Basic Science Research Programs through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning, Republic of Korea [NRF-2018R1D1A1B07048831]
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Background/Aim: Neoadjuvant chemotherapy (NAC) can affect tumors and the tumor microenvironment. As changes in tumor-infiltrating lymphocytes (TILs) after NAC and the resulting clinical significance have not been clearly defined, we evaluated both in triple negative breast cancer (TNBC). Materials and Methods: TIL level was histologically analyzed in pre-NAC biopsy and post-NAC operation specimens from 104 TNBC cases with residual invasive carcinoma after NAC. Results: Forty-three cases (41.3%) showed decreases in TIL level, whereas 29 cases (27.9%) showed increases and no significant changes were found in 32 cases (30.8%). A decrease or increase in TIL levels corresponded to a better disease-free survival (DFS) as compared to unchanged levels. In multivariate analysis, a change in TIL level was an independent prognostic factor for DFS. Conclusion: We identified a prognostic significance of TIL changes after NAC. Assessment of TILs before and after NAC can provide valuable prognostic information for TNBC patients.
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