Article
Biochemistry & Molecular Biology
Yiying Zhu, Zhangxun Zhao, Minggao Xue, Dan Wang, Guifeng Su, Xiaoman Ju, Qihong Yang, Shaohua Zhang, Dongmei Fan, Huifang Zhu, Min Yu, Yan Li, Lingmei Kong, Hongyu Zhou
Summary: Activation of the NKG2D receptor can enhance the sensitivity of leukemia cells to NK cell cytotoxicity, and this can be achieved through the use of drugs such as Ciclopirox Olamine (CPX). CPX can increase the expression of NKG2D ligands (NKG2DLs) on leukemia cells, thereby enhancing the efficacy of NK cell-mediated immunotherapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Abrar Ul Haq Khan, Melinda Blimkie, Doo Seok Yang, Mandy Serran, Tyler Pack, Jin Wu, Ji-Young Kang, Holly Laakso, Seung-Hwan Lee, Yevgeniya Le
Summary: LDR significantly influenced the proportion, proliferation, activation, and function of immune cells, particularly NK and T cells, but had no noticeable impact on mammary cancer development. The study also demonstrated the modulation of the cross-talk between NKG2D receptor and its ligands by LDR exposure at different time points.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Alessandro Mormino, Germana Cocozza, Giulia Fontemaggi, Sergio Valente, Vincenzo Esposito, Antonio Santoro, Giovanni Bernardini, Angela Santoni, Francesco Fazi, Antonello Mai, Cristina Limatola, Stefano Garofalo
Summary: HDAC8 plays a key role in glioma growth and tumor microenvironment by regulating immune response. Inhibition of HDAC8 reduces tumor volume and controls glioma migration by increasing the acetylation of alpha-tubulin. Additionally, HDAC8 modulates the immunogenicity of the tumor microenvironment by regulating gene transcription of NKG2D ligands.
Article
Immunology
Fangming Wang, Xuejiao Dong, Jing Wang, Feiya Yang, Donghua Liu, Jianlin Ma, Shuai Liu, Dehua Chang, Nianzeng Xing
Summary: The study shows that large-scale ex vivo expanded NK cells exhibit significant cytotoxicity against prostate cancer and demonstrate excellent therapeutic efficacy in a preclinical mouse model of castration-resistant prostate cancer.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Cell Biology
Reem Alkhayer, Viviane Ponath, Miriam Frech, Till Adhikary, Johannes Graumann, Andreas Neubauer, Elke Pogge von Strandmann
Summary: This study identifies the transcription factor KLF4 as associated with the MICA promoter, and demonstrates that pharmacological activation of KLF4 leads to increased expression of MICA in AML cells. The small compound APTO253, which activates KLF4, also inhibits MYC expression and causes DNA damage in AML cells. The induction of MICA expression renders AML cells more susceptible to NK cell-mediated killing, suggesting a potential therapeutic approach for targeting AML cells.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Carolina Hernandez, Karen Toledo-Stuardo, Paulina Garcia-Gonzalez, Macarena Garrido-Tapia, Karina Kramm, Jose Alejandro Rodriguez-Siza, Marcela Hermoso, Carolina H. Ribeiro, Maria Carmen Molina
Summary: Stimulation of human gastric adenocarcinoma cells with H. pylori promotes the expression of NKG2DL, leading to an immune response that may contribute to either gastric tissue damage or tumor immune evasion. The upregulation of MICA and ULBP4 on the surface of stimulated cells enables NK cell cytotoxic activation, suggesting a potential role in anti-tumor immunity.
Article
Biochemistry & Molecular Biology
Elisabetta Vulpis, Luisa Loconte, Chiara Cassone, Fabrizio Antonangeli, Giulio Caracciolo, Laura Masuelli, Francesca Fazio, Maria Teresa Petrucci, Cinzia Fionda, Alessandra Soriani, Cristina Cerboni, Marco Cippitelli, Angela Santoni, Alessandra Zingoni
Summary: Natural Killer (NK) cells are innate cytotoxic lymphoid cells that play a crucial role in cancer immunosurveillance. The secretion of NKG2D ligands (NKG2DLs) through extracellular vesicles (EVs) is a mechanism used by cancer cells to evade NKG2D-mediated immunosurveillance. This study investigates the spreading of NKG2DLs through EV-mediated cross-dressing on multiple myeloma (MM) cells and the potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Yimin Tong, Gansheng Shi, Gaowei Hu, Xiaoyou Hu, Lin Han, Xiaofeng Xie, Yongfen Xu, Rong Zhang, Jing Sun, Jin Zhong
Summary: Studies have shown that photoactivated nanosized TiO2 can efficiently inhibit viral infections under low irradiation conditions. It is particularly effective against hepatitis C virus and can also partially inhibit other viruses. Mechanistically, the photoactivated TiO2 attacks the viral RNA genome, leading to virus inactivation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Shaojun Zhang, Wenze Huang, Lili Ren, Xiaohui Ju, Mingli Gong, Jian Rao, Lei Sun, Pan Li, Qiang Ding, Jianwei Wang, Qiangfeng Cliff Zhang
Summary: Comparative analysis revealed common and virus-specific host responses, identifying vRNA-associated proteins that either promote or restrict viral infection. The study highlighted how SARS-CoV-2 hijacks the host factor IGF2BP1 to stabilize vRNA and enhance viral translation. Interactome-informed drug repurposing led to the identification of potential broad-spectrum antivirals, including Cepharanthine and Trifluoperazine, with efficacy against the emerging SARS-CoV-2 B.1.351 variant.
Review
Microbiology
Ruben Gonzalez, Santiago F. Elena
Summary: The microbiome has a significant impact on viral infections by modulating host defense responses and immunity, thus influencing the outcome of pathogen infections. Understanding the interaction between microbiome and pathogenic viruses can lead to new strategies to fight viral infections and improve antiviral therapies.
Review
Plant Sciences
Rui Li, Yongfang Yang, Hao Lou, Weicheng Wang, Jianbin Yan, Xiaoyi Shan, Daoxin Xie
Summary: Plants and microbial pathogens engage in fierce warfare, with jasmonate playing a key role. Pathogens manipulate jasmonate to disrupt hormonal signaling balance for efficient infection of host plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Medicine, General & Internal
Laura Strobel, Kilian Vomstein, Christiana Kyvelidou, Susanne Hofer-Tollinger, Katharina Feil, Ruben-Jeremias Kuon, Susanne Ebner, Jakob Troppmair, Bettina Toth
Summary: In this study, we found that compared to sRPL patients, sCtrls had higher numbers of CD56(+) and CD56(dim)CD16(bright) cells. Furthermore, sRPL patients had lower numbers of CD56(dim)CD16(bright)NKG2D(+) and CD56(dim)CD16(bright)NKp46(+) compared to sCtrls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Nayoung Kim, Mi Yeon Kim, Woo Seon Choi, Eunbi Yi, Hyo Jung Lee, Hun Sik Kim
Summary: GSK-3 alpha primarily restrains the expression of activating receptor ligands on target cells, reducing their susceptibility to NK cells, suggesting a potential strategy to enhance tumor cell susceptibility to NK cells.
Article
Microbiology
Kiera L. Clayton, Geetha Mylvaganam, Alonso Villasmil-Ocando, Heather Stuart, Marcela Maus, Mohammad Rashidian, Hidde L. Ploegh, Bruce D. Walker
Summary: NK cells target HIV-infected CD4(+) T cells and use ADCC to eliminate the infected targets. However, HIV-infected macrophages resist NK cell killing and skew the response towards cytokine production instead of cytolytic contents. This evasion of cytolytic function by HIV-infected macrophages highlights the importance of eliminating them in HIV cure efforts.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
P. Moussa, G. Abrahamsen, N. Fodil, R. P. Gopalakrishnan, M. Mancini, E. Dissen, P. C. Saether, S. A. Wiltshire, G. A. Boivin, G. Caignard, A. Spurkland, S. M. Vidal
SCIENTIFIC REPORTS
(2015)
Review
Biochemistry & Molecular Biology
Mathieu Mancini, Silvia M. Vidal
Article
Immunology
Mathieu Mancini, Gregory Caignard, Benoit Charbonneau, Anne Dumaine, Nila Wu, Gabriel A. Leiva-Torres, Steve Gerondakis, Angela Pearson, Salman T. Qureshi, Robert Sladek, Silvia M. Vidal
JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Mathieu Mancini, Benoit Charbonneau, David Langlais, Silvia M. Vidal
Summary: This study explored the role of the c-Rel transcription factor in driving HSE in HSV-1 infected mice, revealing early signs of HSE development in high-responding Rel(C307X) mice before clinical symptoms appeared, with pathological cell infiltration occurring at the onset of HSE. These findings suggest that c-Rel acts as an early regulator of viral and host responses during mouse HSE.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Barbara C. Mindt, Sai Sakktee Krisna, Claudia U. Duerr, Mathieu Mancini, Lara Richer, Silvia M. Vidal, Steven Gerondakis, David Langlais, Joerg H. Fritz
Summary: The NF-kappa B subunit c-Rel is crucial for effective innate pulmonary type 2 immune responses, regulated by IL-33-induced expression and nuclear translocation. Intrinsic deficiency of c-Rel in ILC2s does not affect development or homeostatic numbers, but alters activation status and the expression of key stimulatory receptors and type 2 signature cytokines. Rel(-/-) mice suggest that c-Rel promotes acute ILC2-driven allergic airway inflammation, highlighting its potential as a therapeutic target for allergic asthma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Rayoun Ramendra, Mathieu Mancini, Jose-Mauricio Ayala, Lin Tze Tung, Stephane Isnard, John Lin, Jean-Pierre Routy, Anastasia Nijnik, David Langlais
Summary: The study demonstrates that BDG induces glutathione synthesis and metabolism in monocytes, which is a major promoter of the acute functional response of monocytes to infections.
FRONTIERS IN IMMUNOLOGY
(2021)