Article
Surgery
P. Bisagni, F. T. Armao, M. Longhi, M. Bastazza, G. Russo, G. Cipolla, M. A. Pedrazzini, S. Paglia
Summary: This study analysed the indications and outcomes of video-assisted thoracoscopic surgery (VATS) in COVID-19 patients with complications such as spontaneous pneumothorax, pneumatocele, and empyema. The study found that VATS can be considered an extreme yet effective treatment in patients who can tolerate general anaesthesia.
UPDATES IN SURGERY
(2023)
Article
Medicine, General & Internal
Fatima El Bozouiki, Mohamed Moumkin, Jihane El Melhaoui, Sanaa Hammi
Summary: Current evidence suggests that intrathoracic gas effusions, such as pneumomediastinum and pneumothorax, can occur in COVID-19 patients even without mechanical ventilation. This study reports 9 cases of spontaneous intrathoracic gas effusions in hospitalized COVID-19 patients without respiratory support. The incidence of spontaneous intrathoracic gas effusions is low at 0.5%, with various manifestations and outcomes.
Article
Medicine, General & Internal
Gokhan Corapli, Veysi Tekin
Summary: This study analyzed the characteristics and risk factors of patients hospitalized with COVID-19 who developed pneumothorax. It found that advanced age and male gender increase the risk of pneumothorax, while smoking, sepsis, and mechanical ventilation do not increase this risk. Additionally, the presence of comorbidity is associated with higher mortality rates in these patients.
Article
Respiratory System
Akira Iyoda, Yoko Azuma, Takashi Sakai, Satoshi Koezuka, Hajime Otsuka, Atsushi Sano
Summary: The novel clinical finding of the pulmonary delayed inflation (PDI) sign is mainly observed in patients aged 34 and younger, indicating a potential peripheral bronchial abnormality and association with bleb and bulla formation in young patients with spontaneous pneumothorax.
BMC PULMONARY MEDICINE
(2021)
Article
Medicine, General & Internal
Claudiu-Eduard Nistor, Daniel Pantile, Camelia Stanciu-Gavan, Adrian Ciuche, Horatiu Moldovan
Summary: This study compared the diagnosis and treatment of patients with COVID-19 pneumothorax and non-COVID-19 pneumothorax. The results showed that patients with COVID-19 pneumothorax had more severe clinical symptoms and a higher prevalence of respiratory comorbidities. Non-COVID-19 patients underwent surgical treatment to remove the air from the pleural cavity, while COVID-19 patients mainly received systemic treatment.
MEDICINA-LITHUANIA
(2022)
Article
Immunology
Xiaodong Tian, Ling Liu, Wenguo Jiang, He Zhang, Wenjun Liu, Jing Li
Summary: This study examined the antibody responses of 484 recovered patients to SARS-CoV-2, revealing that the majority of patients maintained antibodies against the virus post-recovery, with neutralization activities significantly correlated with antibody responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Kensuke Konagaya, Hiroyuki Yamamoto, Tomoki Nishida, Tomotaka Morita, Tomoyuki Suda, Jun Isogai, Hiroyuki Murayama, Hidemitsu Ogino
Summary: COVID-19-related pneumothorax is rare but has high mortality and treatment difficulty. This case report presents a patient with refractory pneumothorax and discusses the successful use of OWT and VAC therapy for controlling persistent air leaks. The case provides a new perspective and therapeutic option for combating COVID-19-related pneumothorax.
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Lisa Baumann Kreuziger, Michelle Sholzberg, Mary Cushman
Summary: COVID-19 patients are at higher risk of developing thrombosis, both microvascular and macrovascular. Therapeutic heparin may be beneficial for noncritically ill hospitalized patients, while prophylactic-dose heparin is recommended for critically ill patients. Collaborative research and funding have improved the care of hospitalized COVID-19 patients.
Article
Multidisciplinary Sciences
Bin Yang, Junpeng Fan, Jia Huang, Ensong Guo, Yu Fu, Si Liu, Rourou Xiao, Chen Liu, Funian Lu, Tianyu Qin, Chao He, Zizhuo Wang, Xu Qin, Dianxing Hu, Lixin You, Xi Li, Tian Wang, Peng Wu, Gang Chen, Jianfeng Zhou, Kezhen Li, Chaoyang Sun
Summary: Persistent SARS-CoV-2 infection in COVID-19 patients is associated with immune suppression and reduced expression of ribosomal protein genes, as revealed by single-cell RNA sequencing and other data analysis.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Alvaro Planchuelo-Gomez, David Garcia-Azorin, Angel L. Guerrero, Margarita Rodriguez, Santiago Aja-Fernandez, Rodrigo de Luis-Garcia
Summary: Patients with persistent headache after COVID-19 resolution show diverse changes in brain structure, including both gray matter and white matter alterations. Compared to individuals without headache, these patients have lower cortical gray matter volume and thickness, accompanied by impaired white matter fiber bundles. Compared to migraine patients, those with persistent headache after COVID-19 recovery exhibit higher cortical volume and thickness in certain brain regions, as well as lower subcortical volume. The study suggests that persistent headache after COVID-19 resolution could be considered an intermediate state between normality and migraine.
JOURNAL OF NEUROLOGY
(2023)
Review
Infectious Diseases
Daniele Focosi, Fabrizio Maggi, Alessandra D'Abramo, Emanuele Nicastri, David J. Sullivan
Summary: After the third year of the COVID-19 pandemic, immunocompromised patients face persistent infection and ineffective treatment with standard antiviral monotherapy. Combined antiviral therapies can mitigate these consequences.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Sunil Sharma, Varun Badami, Edward Rojas, Rahul Sangani, Kyle Chapman, Carlo Avalon, Austin King, Sijin Wen
Summary: This study is a retrospective analysis of COVID-19 patients, aiming to assess the incidence of barotrauma and its impact on mortality. The results show a high incidence of barotrauma in COVID-19 patients, which is related to increased mortality.
Article
Behavioral Sciences
Marie-Luise Kieseler, Brad Duchaine
Summary: This article reports that COVID-19 can cause prosopagnosia, cognitive and speech impairments, and psychosis. A case study of a 28-year-old woman who contracted COVID-19 found that she experienced face recognition difficulties even after recovery, while other visual and memory abilities seemed unaffected. Survey data also showed that a majority of long COVID patients reported reductions in visual recognition and navigation abilities.
Article
Medicine, General & Internal
Mhd Baraa Habib, Ibrahim Mohammad Obeidat, Khaled Ali, Mohamed Abdelrazek, Mouhand F. H. Mohamed
Summary: This case illustrates the rare occurrence of bronchopleural fistula in COVID-19 pneumonia, even in the absence of risk factors or mechanical ventilation administration.
CLINICAL CASE REPORTS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Takahiro Nakagomi, Taichiro Goto, Yosuke Hirotsu, Rumi Higuchi, Toshiharu Tsutsui, Kenji Amemiya, Toshio Oyama, Hitoshi Mochizuki, Masao Omata
Summary: A 71-year-old man with drug-induced interstitial pneumonia and concurrent COVID-19 infection was found to have a pulmonary mass, indicating coexisting lung cancer. After one month of COVID-19 pneumonia resolution, the patient underwent elective upper lobectomy. However, postoperatively, there was an acute exacerbation of interstitial pneumonia, resulting in the patient's death on the fifteenth day. Despite the resolved COVID-19 infection, high levels of COVID-19-derived RNA were detected in the lung parenchyma sample, suggesting a potential local persistence of the virus and the risk of acute exacerbation of interstitial pneumonia due to secondary stressors such as surgery.
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Antonio Miceli, Andrea Attilio Moneta, Francesco Donatelli, Mattia Glauber
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Medicine, General & Internal
Gloria Santangelo, Alfonso Ielasi, Mariano Pellicano, Azeem Latib, Maurizio Tespili, Francesco Donatelli
Summary: Transcatheter aortic valve replacement has revolutionized the management of aortic valve disease in the past 15 years and has become the standard of care for patients with varying surgical risks. This review provides an update on the latest advancements in next-generation transcatheter heart valves and delivery systems.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Andrea Buono, Diego Maffeo, Giovanni Troise, Francesco Donatelli, Maurizio Tespili, Alfonso Ielasi
Summary: Aortic valve-in-valve (ViV) procedure is a valid treatment option for patients with bioprosthetic heart valve (BHV) degeneration. However, it is technically more challenging compared to native trans-catheter aortic valve replacement (TAVR). Multimodal imaging is crucial for diagnosis and pre-procedural planning.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Monica Barki, Alfonso Ielasi, Andrea Buono, Gabriele Maliandi, Mariano Pellicano, Marta Bande, Francesco Casilli, Francesca Messina, Giuseppe Uccello, Daniele Briguglia, Massimo Medda, Maurizio Tespili, Francesco Donatelli
Summary: In patients with severe symptomatic AS undergoing TAVR, the newly available BE Myval THV demonstrated comparable early clinical performance and safety to the commonly used SE Evolut R THV. It was associated with a lower rate of permanent pacemaker implantation and more than moderate paravalvular leak within 30 days and 6 months after the procedure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Antonio Miceli, Francesco Donatelli, Mattia Glauber, Claudio Napoli
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Andrea Montisci, Mattia Glauber, Antonio Miceli
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Andrea Montisci, Vittorio Palmieri, Maria Teresa Vietri, Silvia Sala, Ciro Maiello, Francesco Donatelli, Claudio Napoli
Summary: Big Data and its derived analysis techniques are considered a revolution in modern medicine, particularly in the field of cardiac surgery where it helps to uncover hidden associations and patterns. The use of predictive models based on Big Data has sparked interest in personalized medicine and highlighted the limitations of randomized controlled trials in representing the real world.
JOURNAL OF CARDIOTHORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Italo Calamai, Massimiliano Greco, Stefano Finazzi, Marzia Savi, Gaia Vitiello, Elena Garbero, Rosario Spina, Andrea Montisci, Silvia Mongodi, Guido Bertolini
Summary: Lung ultrasound (LUS) is a readily available, safe, and cost-effective technique for diagnosing and monitoring critically ill patients. Analysis of LUS reports from different ICUs revealed significant variations. Adoption of an integrated structured report promotes a systematic approach in scanning and reporting, potentially impacting the clinical applications of LUS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Filippo Cali, Matteo Pagnesi, Elisa Pezzola, Andrea Montisci, Marco Metra, Marianna Adamo
Summary: Papillary muscle rupture (PMR) is a rare but serious complication of acute myocardial infarction (AMI) with high mortality and morbidity. Surgery, the standard treatment, is associated with high perioperative risks due to unstable hemodynamics. However, percutaneous mitral transcatheter edge-to-edge repair (M-TEER) has been found to be safe and effective in reducing mitral regurgitation in post-AMI PMR patients, with low in-hospital mortality and complications.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Federico Pappalardo, Andrea Montisci
JOURNAL OF CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Andrea Montisci, Giulia Maj, Corrado Cavozza, Andrea Audo, Stefano Benussi, Fabrizio Rosati, Sergio Cattaneo, Lorenzo Di Bacco, Federico Pappalardo
Summary: Complex ascending and aortic arch surgery requires different cerebral protection strategies, including deep or moderate hypothermia and various cerebral perfusion techniques, to prevent brain damage. The etiology of the damage involves multiple factors, such as cerebral embolism, hypoperfusion, hypoxia, and inflammatory response. This narrative review describes the pathophysiology of cerebral damage during aortic surgery, analyzes the options for brain protection, and discusses the current systems of intraoperative brain monitoring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Vittorio Palmieri, Maria Teresa Vietri, Andrea Montalto, Andrea Montisci, Francesco Donatelli, Enrico Coscioni, Claudio Napoli
Summary: Cardiovascular (CV) risk factors and disease are increasingly reported among survivors of anticancer treatments. It is unclear if drugs used to prevent CV diseases in the general population are effective in survivors of anticancer treatments. Prognosis after cardiac surgery treatments may differ in survivors of anticancer treatments and require specific risk assessment.
Review
Computer Science, Information Systems
Vittorio Palmieri, Andrea Montisci, Maria Teresa Vietri, Paolo C. Colombo, Silvia Sala, Ciro Maiello, Enrico Coscioni, Francesco Donatelli, Claudio Napoli
Summary: This study explores the opportunities and limitations of using artificial intelligence (AI) and big data in the field of heart transplantation. The results show that AI performs well in predicting prognosis and diagnosing heart transplantation, but there are risks of bias, lack of external validation, and limited applicability. Therefore, more unbiased research and high-quality data are needed to support the use of medical AI in clinical decision-making.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Medda, Francesco Casilli, Marta Bande, Maurizio Tespili, Francesco Donatelli
Summary: TAVR is a treatment option for severe aortic valve stenosis, and may be a better choice for patients with a small aortic annulus. However, risks such as coronary obstruction and annulus rupture must be prevented.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)
