The Impact of Primary Tumor Surgery on Survival in HER2 Positive Stage IV Breast Cancer Patients in the Current Era of Targeted Therapy

End-of-study analysis from the phase III, randomized, double-blind, placebo (Pla)-controlled CLEOPATRA study of first-line (1L) pertuzumab (P), trastuzumab (H), and docetaxel (D) in patients (pts) with HER2-positive metastatic breast cancer (MBC).

(2019) Sandra M. Swain et al.   JOURNAL OF CLINICAL ONCOLOGY

Subcutaneous vs Intravenous Trastuzumab for Patients With ERBB2-Positive Early Breast Cancer

(2019) Christian Jackisch et al.   JAMA Oncology

Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01

(2018) Atilla Soran et al.   ANNALS OF SURGICAL ONCOLOGY

De Novo Stage 4 Metastatic Breast Cancer: A Surgical Disease?

(2018) Thanh U. Barbie et al.   ANNALS OF SURGICAL ONCOLOGY

Survival Impact of Locoregional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancers in a Large Multicentric Cohort Study: A Propensity Score-Matched Analysis

(2018) Elvire Pons-Tostivint et al.   ANNALS OF SURGICAL ONCOLOGY

Racial/ethnic differences in the outcomes of patients with metastatic breast cancer: contributions of demographic, socioeconomic, tumor and metastatic characteristics

(2018) Jin-Xiao Ren et al.   BREAST CANCER RESEARCH AND TREATMENT

FDA Approval Summary: Pertuzumab for adjuvant treatment of HER2-positive early breast cancer

(2018) Lynn J. Howie et al.   CLINICAL CANCER RESEARCH

Safety profile of subcutaneous trastuzumab for the treatment of patients with HER2-positive early or locally advanced breast cancer: primary analysis of the SCHEARLY study

(2018) Milvia Zambetti et al.   EUROPEAN JOURNAL OF CANCER

Significance of primary lesion resection in Stage IV breast cancer

(2017) Tadahiko Shien et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

The impact of surgical excision of the primary tumor in stage IV breast cancer on survival: a meta-analysis

(2017) Shuangshuang Lu et al.   Oncotarget

Surgical Resection of the Primary Tumor in Women With De Novo Stage IV Breast Cancer

(2017) Whitney O. Lane et al.   ANNALS OF SURGERY

Clinicopathological and surgical factors associated with long-term survival in patients with HER2-positive metastatic breast cancer

(2016) K. Harano et al.   BREAST CANCER RESEARCH AND TREATMENT

Initial Surgery and Survival in Stage IV Breast Cancer in the United States, 1988-2011

(2016) Alexandra Thomas et al.   JAMA Surgery

Racial differences in outcomes for patients with metastatic breast cancer by disease subtype

(2015) Ines Vaz-Luis et al.   BREAST CANCER RESEARCH AND TREATMENT

Locoregional treatment versus no treatment of the primary tumour in metastatic breast cancer: an open-label randomised controlled trial

(2015) Rajendra Badwe et al.   LANCET ONCOLOGY

Racial disparities in treatment patterns and clinical outcomes in patients with HER2-positive metastatic breast cancer

(2013) Hope S. Rugo et al.   BREAST CANCER RESEARCH AND TREATMENT

The impact of comorbidity on cancer survival: a review

(2013) Mette Sogaard et al.   Clinical Epidemiology

Locally recurrent or metastatic breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2012) F. Cardoso et al.   ANNALS OF ONCOLOGY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Surgery of the primary tumor does not improve survival in stage IV breast cancer

(2011) Laura Dominici et al.   BREAST CANCER RESEARCH AND TREATMENT

Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stage IV breast cancer in the era of targeted therapy

(2010) Heather B. Neuman et al.   CANCER

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Prognosis of Women With Metastatic Breast Cancer byHER2Status and Trastuzumab Treatment: An Institutional-Based Review

(2009) Shaheenah Dawood et al.   JOURNAL OF CLINICAL ONCOLOGY

Perioperative Use of β-blockers and COX-2 Inhibitors May Improve Immune Competence and Reduce the Risk of Tumor Metastasis

(2008) Marganit Benish et al.   ANNALS OF SURGICAL ONCOLOGY

Matched Pair Analyses of Stage IV Breast Cancer with or Without Resection of Primary Breast Site

(2008) B. Cady et al.   ANNALS OF SURGICAL ONCOLOGY

Breast surgery in stage IV breast cancer: impact of staging and patient selection on overall survival

(2008) Andrea C. Bafford et al.   BREAST CANCER RESEARCH AND TREATMENT

Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy

(2008) Madhuri Kakarala et al.   JOURNAL OF CLINICAL ONCOLOGY