Journal
CARDIOVASCULAR RESEARCH
Volume 110, Issue 2, Pages 165-177Publisher
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvw046
Keywords
Abdominal aortic aneurysm; Micro-RNAs; Human studies; Animal models
Categories
Funding
- British Heart Foundation
- European Research Council
- Universite Nice Sophia Antipolis
- Societe de Chirurgie Vasculaire et Endovasculaire de Langue Francaise
- Fondation pour la Recherche Medicale
- British Heart Foundation [RG/15/11/31593] Funding Source: researchfish
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Abdominal aortic aneurysm (AAA) is a major health concern and may be associated with high rates of mortality linked to acute complications. Diagnosis and treatment are, respectively, based on imaging and surgical techniques. Drug-based therapies are still mostly ineffective, which highlight a real unmet need. Major pathophysiological mechanisms leading to aneurysm formation involve inflammatory processes, degradation of the extracellular matrix, and loss of smooth muscle cells. However, the precise cellular and molecular pathways are still poorly understood. Recently, microRNAs have emerged as major intracellular players in a wide range of biological processes, and their stability in extracellular medium within microvesicles has led to propose them as mediators of intercellular crosstalk and as potential biomarkers and therapeutic targets in a variety of disease settings. To date, several studies have been performed to address the involvement of micro-RNAs (miRs) in aneurysm formation and complications. Here, we discuss the roles and implications of miRs in animal models and their relevance to human AAA.
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