Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 59, Issue 34, Pages 14265-14269Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004658
Keywords
alcohols; asymmetric catalysis; reduction; ruthenium; sulfones
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Funding
- Royal Society
- Advantage West Midlands (AWM)
- European Regional Development Fund (ERDF)
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The sulfone functional group has a strong capacity to direct the asymmetric transfer hydrogenation (ATH) of ketones in the presence of [(arene)Ru(TsDPEN)H] complexes by adopting a position distal to the eta(6)-arene ring. This preference provides a means for the prediction of the sense of asymmetric reduction. The sulfone group also facilitates the formation of a range of reduction substrates, and its ready removal provides a route to enantiomerically enriched alcohols that would otherwise be extremely difficult to prepare by direct ATH of the corresponding ketones.
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