Journal
ANALYTICA CHIMICA ACTA
Volume 1105, Issue -, Pages 82-86Publisher
ELSEVIER
DOI: 10.1016/j.aca.2020.01.030
Keywords
Yeast; Mesoporous Titania; miRNA; Cancer; Electrochemical sensing detection
Categories
Funding
- Zhejiang Province Public Welfare Technology Application Research Project [LGF19E020002]
- Natural Science Foundation of Jiangsu Province [BK20181444]
- National Natural Science Foundation of China [51102152]
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Electrochemical sensing is an effective, low-cost technology for cancer detection. In this study, mesoporous TiO2 was prepared via biomimetic synthesis based on yeast cell templates, and used to prepare a modified electrode for the sensitive detection of pancreatic cancer miR-1290. The structure and the morphology of the TiO2 were characterized by X-ray diffraction (XRD), N-2 adsorption-desorption isotherm (NADI), Atomic force microscopy (AFM), and electron probe microanalysis (EPMA). As a sensing active material, the yeast-templated mesoporous TiO2 could detect pancreatic cancer miRNAs with single-nucleotide discrimination. The sample prepared by calcination at 400 degrees C showed the best electrochemical sensing activity. Moreover, compared with the blank electrode, the yeast mesoporous TiO2 sensing electrode could oxidize the pancreatic cancer microRNAs at a lower potential, which minimized the interference from oxygen evolution reaction at high potentials. (C) 2020 Elsevier B.V. All rights reserved.
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