Journal
ANALYTICA CHIMICA ACTA
Volume 1108, Issue -, Pages 61-69Publisher
ELSEVIER
DOI: 10.1016/j.aca.2020.02.053
Keywords
Multicolor electrochromism sensor; Visualized detection; Bioanalysis; CEA detection
Categories
Funding
- National Natural Science Foundation of China [21777046]
- Guangzhou Construction and sharing of Technological Innovation Platform, Guangzhou, China [201509090001]
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In this work, a multicolor visual immunoassay platform was developed. The photoelectric effects of Ag(2)SNPs@ZnO NTs made the color changes of PANI/PB, which enabled visual inspection of CEA. Under the visible light excitation, Ag(2)SNPs@ZnO NTs generates electron-holes. Where, photoelectrons will pass electrical circuit to PB and photoinduced holes will oxidize PANI, which making the PANI/PB composite changes from emerald green-blue-purple-black colors. When CEA was incubated, the migration rate of photogenerated carriers is slowed down owing to the steric hindrance, resulting in different color changes of PANI/PB. In addition, the average green channel of PANI/PB read by photoshop has a certain correlated linear relationship with the concentration of CEA. Meanwhile, we can observe the color transformation of PANI/PB with our own eyes. By integrating advantages of photoelectrochemistry and colorimetry, the linear range of CEA detection was 0.1-20 ng/mL, and the detection limit was 0.05 ng/mL (S/N = 3). More importantly, this multicolor sensing method is very convenient, simple and low-cost. The photocarriers-modulated colorimetric strategy also provides a novel idea for visual portable platform design in clinical diagnosis. (C) 2020 Elsevier B.V. All rights reserved.
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