Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 20, Issue 7, Pages 1907-1910Publisher
WILEY
DOI: 10.1111/ajt.15909
Keywords
clinical research; practice; immunosuppressant; immunosuppression; immune modulation; infection and infectious agents; infection and infectious agents - viral; liver transplantation; hepatology
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Funding
- National Natural Science Foundation of China [81500665]
- Medical Health Science and Technology Project of Zhejiang Provincial Health Commission [2018ZD039]
- High Level Creative Talents from Department of Public Health in Zhejiang Province
- Zhejiang Key Research and Development Plan Emergency Project [2020C03123]
- Project of New Century 551 Talent Nurturing in Wenzhou
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Liver injury is common in patients with COVID-19, but little is known about its clinical presentation and severity in the context of liver transplant. We describe a case of COVID-19 in a patient who underwent transplant 3 years ago for hepatocellular carcinoma. The patient came to clinic with symptoms of respiratory disease; pharyngeal swabs for severe acute respiratory syndrome coronavirus 2 were positive. His disease progressed rapidly from mild to critical illness and was complicated by several nosocomial infections and multiorgan failure. Despite multiple invasive procedures and rescue therapies, he died from the disease. The management of COVID-19 in the posttransplant setting presents complex challenges, emphasizing the importance of strict prevention strategies.
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