Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 84, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/aji.13262
Keywords
endometrial stem cell; endometrium; estrogen; infertility; Intrauterine adhesion; TGF-beta 1
Categories
Funding
- National Natural Science Foundation of China [81302260, 31970798, 31671200]
- Shanghai Natural Science Foundation [7ZR1403200]
- NPFPC Key Laboratory of Reproduction Regulation [CX2017-2]
- Program for Zhuoxue of Fudan University
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Intrauterine adhesion (IUA), led by trauma to the basal layer, can prevent the endometrium from growing, resulting in complications in females, such as infertility and amenorrhea. Transforming growth factor-beta 1 (TGF-beta 1) plays a crucial role in inducing and promoting the differentiation and proliferation of mesenchymal cells, in the secretion of extracellular matrix-associated components, and is a major cytokine in initiating and terminating tissue repair downstream of the TGF-beta/Smad signaling pathway. Some evidence supports that TGF-beta 1 is closely associated with the occurrence and development of IUA, and is regarded as an early risk factor of disease recurrence. Furthermore, the role of TGF-beta 1 has been demonstrated to be potentially regulated by a variety of cytokines, hormones, enzymes, and microRNAs. This review provides an overview of the expression, function, and regulation of TGF-beta 1 in IUA, with a brief discussion and perspectives on its future clinical implications on the diagnosis and treatment of IUA.
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