Article
Ophthalmology
Marianne O. Price, Francis W. Price
Summary: The purpose of this study was to evaluate the 15-year outcomes of Descemet stripping endothelial keratoplasty (DSEK). The results showed that DSEK provided excellent long-term visual rehabilitation and graft survival in this early cohort.
Article
Ophthalmology
Myriam S. Bohm, Adam Wylegala, Pia Leon, Stephan Ong Tone, Joseph B. Ciolino, Ula Jurkunas
Summary: The one-year outcomes of preloaded Descemet membrane endothelial keratoplasty (pDMEK) and non-preloaded DMEK (n-pDMEK) in patients with Fuchs endothelial corneal dystrophy were found to be similar. There were no significant differences in postoperative visual acuity, central corneal thickness, endothelial cell count, and complication rates between the two procedures. The study suggests that eye bank-prepared pDMEK tissues are a useful tool in treating endothelial dysfunction.
Article
Ophthalmology
Antonio Moramarco, Vito Romano, Rocco Luigi Modugno, Giulia Coco, Pietro Viola, Luigi Fontana
Summary: The purpose of this study was to evaluate the effectiveness and safety of the Yogurt technique for DMEK graft preparation. The results showed that the DMEK Tzamalis punch can be used as an effective and safe method for DMEK graft preparation, and it can be performed successfully by relatively inexperienced surgeons.
Article
Medicine, General & Internal
Marcus Ang, Feng He, Stephanie Lang, Charumathi Sabanayagam, Ching-Yu Cheng, Anshu Arundhati, Jodhbir S. Mehta
Summary: This study used machine learning analysis to examine factors associated with 10-year graft survival in Asian eyes undergoing Descemet stripping automated endothelial keratoplasty (DSAEK) or penetrating keratoplasty (PK). The results showed that BK, PK, male recipients, and poor pre-operative visual acuity were associated with graft failure. The study also found that DSAEK had a higher survival rate and lower incidence of complications compared to PK.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Itay Lavy, Nir Erdinest, Ayala Katzir, Naomi London, Eleanor Ngwe Nche, David Smadja
Summary: A novel technique for handling and centration of DMEK grafts is presented, which can reduce surgery time and endothelial cell loss. The technique was successfully used in 27 cases with complex ocular pathology, resulting in improved visual acuity and decreased central corneal thickness post-operatively.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Ting Wang, Peiyan Shi, Fengjie Li, Hua Gao, Suxia Li, Tong Liu, Weiyun Shi
Summary: The study suggests that treatment using FLS-DSEK is promising and may be considered a feasible choice for patients with endothelial dysfunction.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ashik Mohamed, Sunita Chaurasia, Sirisha Senthil, Nikhil S. Choudhari
Summary: This study evaluated the long-term outcomes of DSEK in 52 eyes with ICE syndrome, showing a success rate of approximately 60% at 5 years. Increased intraocular pressure post-DSEK was identified as a significant risk factor for graft failure, while the clinical variant of ICE syndrome did not influence graft survival.
Article
Ophthalmology
Chrishan Duminda Gunasekera, Angeli Christy Yu, Massimo Busin
Summary: This study reports the 22-year clinical outcome of a patient who underwent endokeratoplasty, showing excellent visual acuity and long-term graft survival.
Article
Ophthalmology
Indre Vasiliauskaite, Ruth Quilendrino, Lamis Baydoun, Korine van Dijk, Gerrit R. J. Melles, Silke Oellerich
Summary: The study found that 6-month endothelial cell density (ECD) affects DMEK graft survival, with early cell loss after DMEK negatively impacting long-term ECD outcomes and graft survival. Grafts with low 6-month ECD are at higher risk of failure within 5 years after DMEK.
Article
Medicine, General & Internal
Saiqing Li, Zihao Liu, Binjia Sun, Zelin Zhao, Haiou Wang, Qinxiang Zheng, Wei Chen
Summary: This study compares the outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) performed using an intraocular lens injector (injector) versus the Busin glide in patients with iridocorneal endothelial (ICE) syndrome. The results show that both techniques were successful in delivering the graft and improving visual acuity. However, the injector group had significantly less endothelial cell loss compared to the Busin group. No surgery-related complications were observed in either group. The use of a graft injector may offer safer and more successful graft attachment without the need for anterior chamber irrigation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Jeffrey L. Tapley, Jordan R. Hill, Alex J. Bauer, Megan M. W. Straiko, Michael D. Straiko, Mark A. Terry
Summary: The study aimed to compare the 6-month endothelial cell loss and graft survival in eyes that did not require a postoperative rebubble with eyes that did require a rebubble after DMEK surgery. The results showed that eyes requiring a rebubble had higher rates of endothelial cell loss and lower graft survival at 6 months postoperative, with higher rebubble rates in eyes with failed penetrating keratoplasty and pseudophakic bullous keratopathy.
Article
Ophthalmology
Lanxing Fu, Emma J. Hollick
Summary: The 10-year DSEK survival rate was 79% for all eyes, and 92% for Fuchs endothelial dystrophy. Preoperative glaucoma, previous glaucoma surgery, and regrafts were significant risk factors for graft failure.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Nicolas Cesario Pereira, Jose Alvaro Pereira Gomes, Camile Tonin, Fabiana Orondjian Verardo, Rodolpho Sueiro Felippe, Adriana dos Santos Forseto
Summary: DMEK is an effective treatment for endothelial dysfunction in children under the age of 8, with high success rates and improvements in visual acuity and corneal status post-surgery. Visual stimulation therapy was initiated promptly in all children following surgery, and graft clarity was maintained throughout the follow-up period.
Article
Ophthalmology
Andreas Viberg, Branka Samolov, Berit Bystroem
Summary: The study compares the outcomes of different posterior lamellar corneal transplant procedures for Fuchs endothelial corneal dystrophy, taking into consideration preoperative patient characteristics. The results show that all three surgical methods improved visual acuity in the majority of patients, but DMEK and phacoemulsification plus DSAEK achieved higher levels of visual acuity after 2 years, and phacoemulsification plus DSAEK had a superior graft survival rate. The choice of surgical method should be personalized, considering not only the corneal condition but also each patient's complete medical status and postoperative medical care.
Article
Medicine, General & Internal
Antonio Cano-Ortiz, Alvaro Sanchez-Ventosa, Vanesa Diaz-Mesa, Timoteo Gonzalez-Cruces, Marta Villalba-Gonzalez, Alberto Villarrubia-Cuadrado
Summary: The study finds that using a 3D visualization system for surgery allows the surgeon to be in a more comfortable position. Observing the surgical field on a large screen has advantages for surgical assistance and instruction. Additionally, the study shows that there is a short learning curve for successful use of the 3D visualization system in DMEK and DSO procedures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Renuka S. Birbal, Sorcha Ni Dhubhghaill, Lamis Baydoun, Lisanne Ham, Vincent J. A. Bourgonje, Isabel Dapena, Silke Oellerich, Gerrit R. J. Melles
Article
Ophthalmology
Renuka S. Birbal, Sorcha Ni Dhubhghaill, Vincent J. A. Bourgonje, Jennifer Hanko, Lisanne Ham, Martine J. Jager, Stefan Bohringer, Silke Oellerich, Gerrit R. J. Melles
Letter
Ophthalmology
Renuka S. Birbal, Jack S. Parker, Korine van Dijk, Silke Oellerich, Isabel Dapena, Gerrit R. J. Melles
ACTA OPHTHALMOLOGICA
(2020)
Article
Ophthalmology
Silke Oellerich, Lisanne Ham, Laurence E. Frank, Sandra Gorges, Vincent J. A. Bourgonje, Lamis Baydoun, Korine Van Dijk, Gerrit R. J. Melles
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Renuka S. Birbal, Lamis Baydoun, Lisanne Ham, Alina Miron, Korine Van Dijk, Isabel Dapena, Martine J. Jager, Stefan Bohringer, Silke Oellerich, Gerrit R. J. Melles
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Aytan Musayeva, Eitan Livny, Diana C. Dragnea, Lisanne Ham, Indre Vasiliauskaite, Sorcha Ni Dhubhghaill, Korine van Dijk, Silke Oellerich, Gerrit R. J. Melles
Article
Ophthalmology
Indre Vasiliauskaite, Maloeke de Jong, Ruth Quilendrino, Jacqueline van der Wees, Silke Oellerich, Gerrit R. J. Melles
Summary: The study evaluated the suitability of corneas from septic donors for transplantation by analyzing discard rates and clinical outcomes of DMEK. The results showed that with strict adherence to donor screening protocols, the use of corneas from septic donors for DMEK does not seem to increase the risks for recipients and can expand the donor pool for corneal tissue.
Article
Surgery
Isabel M. A. Bruggenwirth, Marjolein van Reeven, Indre Vasiliauskaite, Danny van der Helm, Bart van Hoek, Alexander F. Schaapherder, Ian P. J. Alwayn, Aad P. van den Berg, Vincent E. de Meijer, Sarwa Darwish Murad, Wojciech G. Polak, Robert J. Porte
Summary: The study found that donors with diabetes mellitus are associated with poorer early post-liver transplant outcomes. Recipients of liver transplants from donors with diabetes had a higher incidence of hepatic artery thrombosis and lower 90-day graft survival compared to those from non-diabetic donors. Further research is needed to explore the increased risk of hepatic artery thrombosis after liver transplantation from donors with diabetes.
TRANSPLANT INTERNATIONAL
(2021)
Review
Ophthalmology
Daniele Spinozzi, Alina Miron, Marieke Bruinsma, Isabel Dapena, Viridiana Kocaba, Martine J. Jager, Gerrit R. J. Melles, Sorcha Ni Dhubhghaill, Silke Oellerich
Summary: Research has focused on developing new treatment options to increase the availability of healthy endothelial grafts as a replacement for traditional corneal transplantation. Both surgery-based and cell-based approaches have emerged as important alternatives to traditional techniques.
ACTA OPHTHALMOLOGICA
(2021)
Article
Ophthalmology
Indre Vasiliauskaite, Sorcha Ni Dhubhghaill, Lisanne Ham, Korine Van Dijk, Silke Oellerich, Gerrit R. J. Melles
Summary: The study analyzed the occurrence of cataract extraction after DMEK in phakic eyes and the impact of phacoemulsification post-DMEK on ECD. Phacoemulsification after DMEK provided good CDVA outcomes, did not cause graft detachment, and led to an acceptable decrease in ECD.
JOURNAL OF REFRACTIVE SURGERY
(2021)
Article
Ophthalmology
Indre Vasiliauskaite, Ruth Quilendrino, Lamis Baydoun, Korine van Dijk, Gerrit R. J. Melles, Silke Oellerich
Summary: The study found that 6-month endothelial cell density (ECD) affects DMEK graft survival, with early cell loss after DMEK negatively impacting long-term ECD outcomes and graft survival. Grafts with low 6-month ECD are at higher risk of failure within 5 years after DMEK.
Review
Ophthalmology
Ozlem Evren Kemer, Emine Esra Karaca, Silke Oellerich, Gerrit Melles
Summary: Endothelial keratoplasty has become a preferred treatment over traditional penetrating keratoplasty due to its faster and more predictable visual recovery with lower rejection rates. Descemet membrane endothelial keratoplasty (DMEK) is now considered the gold standard for various corneal conditions, with ongoing studies focusing on new techniques and modifications for challenging cases.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Cell & Tissue Engineering
Daniele Spinozzi, Alina Miron, Jessica T. Lie, Mehrdad Rafat, Neil Lagali, Gerrit R. J. Melles, Sorcha Ni Dhubhghaill, Isabel Dapena, Silke Oellerich
CELL TRANSPLANTATION
(2020)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)