Combinatorial pathway engineering for optimized production of the anti-malarial FR900098

Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor

(2015) Ryan E. Cobb et al.   CHEMICAL COMMUNICATIONS

Employing a combinatorial expression approach to characterize xylose utilization in Saccharomyces cerevisiae

(2014) Luke N. Latimer et al.   METABOLIC ENGINEERING

Functional optimization of gene clusters by combinatorial design and assembly

(2014) Michael J Smanski et al.   NATURE BIOTECHNOLOGY

Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly

(2013) Farnaz F. Nowroozi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Multivariate modular metabolic engineering of Escherichia coli to produce resveratrol from l-tyrosine

(2013) Junjun Wu et al.   JOURNAL OF BIOTECHNOLOGY

Expression-level optimization of a multi-enzyme pathway in the absence of a high-throughput assay

(2013) Michael E. Lee et al.   NUCLEIC ACIDS RESEARCH

Combinatorial Design of a Highly Efficient Xylose-Utilizing Pathway in Saccharomyces cerevisiae for the Production of Cellulosic Biofuels

(2012) Byoungjin Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biocatalyst development by directed evolution

(2012) Meng Wang et al.   BIORESOURCE TECHNOLOGY

Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy

(2012) Junjun Wu et al.   METABOLIC ENGINEERING

Modular control of multiple pathways using engineered orthogonal T7 polymerases

(2012) Karsten Temme et al.   NUCLEIC ACIDS RESEARCH

Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions

(2012) Surisetti Suresh et al.   TETRAHEDRON

NewN-Acetyltransferase Fold in the Structure and Mechanism of the Phosphonate Biosynthetic Enzyme FrbF

(2011) Brian Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Threat of Artemisinin-Resistant Malaria

(2011) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deciphering the Late Biosynthetic Steps of Antimalarial Compound FR-900098

(2010) Tyler W. Johannes et al.   CHEMISTRY & BIOLOGY

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Biosynthesis of Phosphonic and Phosphinic Acid Natural Products

(2009) William W. Metcalf et al.   Annual Review of Biochemistry

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Cloning, Expression, and Biochemical Characterization of Streptomyces rubellomurinus Genes Required for Biosynthesis of Antimalarial Compound FR900098

(2008) Andrew C. Eliot et al.   CHEMISTRY & BIOLOGY