Article
Endocrinology & Metabolism
Fei Li, Li-Zhong Yan, Yi-Fan Zhang, Zhou-Jun Lin, Yin Li, Xiao Han, Lu Sun, Xiao-Lin Pei, Ya Feng, Qiao Liu, Juan Yang, Qiao Wu, Di Shao, Cheng-Gang Li
Summary: The aim of this study was to explore targeting ASAH1 as a new therapeutic mechanism for CRC. The study found that ASAH1 expression was higher in CRC tissues than normal tissues, and inhibiting ASAH1 reduced the proliferation of CRC cells and protected mice from CRC onset and progression in a xenograft tumor model. Additionally, ASAH1 was possibly associated with autophagy activation in DLD-1 cells. Therefore, ASAH1 has the potential to be developed as a potential therapeutic target for preclinical studies in CRC.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Multidisciplinary Sciences
Bin Tang, Xiaoxue Lu, Yanan Tong, Yuyang Feng, Yilan Mao, Guodong Dun, Jing Li, Qiaolin Xu, Jie Tang, Tao Zhang, Ling Deng, Xiaoyi He, Yuanzhi Lan, Huaxing Luo, Linghai Zeng, Yuanyuan Xiang, Qian Li, Dongzhu Zeng, Xuhu Mao
Summary: Persistent Fusobacterium nucleatum infection promotes the development of colorectal cancer (CRC) by inducing the expression of microRNA-31 (miR-31). F. nucleatum infection inhibits autophagy by miR-31 through inhibiting syntaxin-12 (STX12) and enhances intracellular survival of F. nucleatum. Overexpression of miR-31 in CRC cells promotes tumorigenicity by targeting eIF4EBP1/2, while miR-31 knockout mice are resistant to colorectal tumor formation. These findings highlight miR-31 as a potential diagnostic biomarker and therapeutic target in CRC patients with F. nucleatum infection.
Article
Biochemistry & Molecular Biology
Jinyu Shi, Li Zhou, Hui-Si Huang, Liyuan Peng, Na Xie, Edouard Nice, Li Fu, Cen Jiang, Canhua Huang
Summary: This study reveals that oxiconazole exhibits anti-tumor effect against colorectal cancer (CRC) by inducing autophagy arrest and subsequent apoptosis. Mechanistically, oxiconazole downregulates the antioxidant enzyme peroxiredoxin-2 (PRDX2) to initiate autophagy, leading to growth suppression of CRC cells. The combination of oxiconazole and oxaliplatin achieves an improved anti-tumor effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Oncology
Hongyan Xi, Shuo Wang, Beibei Wang, Xuelan Hong, Xueping Liu, Meichao Li, Ruxia Shen, Qixiu Dong
Summary: Autophagy and apoptosis are important cellular processes that are closely connected and mutually regulated. The balance between autophagy and apoptosis is crucial for cell functionality and survival. Disruption of this balance can lead to disease, particularly tumor formation.
Article
Oncology
Jiali Wang, Tiangong Wang, Shiyun Hu, Jinyun Li, Chao Ni, Meng Ye
Summary: In this study, we identified that hsa_circ_0043278 was significantly downregulated in colorectal cancer tumor samples (P < 0.0001) and cell lines (P < 0.05). The area under the receiver operating characteristic curve was 0.71, showing a sensitivity of 0.72 and specificity of 0.70 (P = 0.0006). Moreover, overexpression of hsa_circ_0043278 inhibited proliferation and migration while promoting apoptosis in colorectal cancer cells.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Microbiology
Dan-Ni Wang, Jin-Jing Ni, Jian-Hui Li, Ya-Qi Gao, Fang-Jing Ni, Zhen-Zhen Zhang, Jing-Yuan Fang, Jie Lu, Yu-Feng Yao
Summary: Increasing evidence indicates that bacteria play a role in promoting tumorigenesis, yet the mechanisms remain poorly understood. This study reveals that Salmonella infection induces changes in the acetylation of host cell proteins, including CDC42. Decreased acetylation of CDC42 impairs its interaction with PAK4, leading to reduced cell apoptosis and enhanced migration and invasion ability. Furthermore, low CDC42 acetylation predicts a poor prognosis in colorectal cancer patients. These findings suggest that bacterial infection promotes tumorigenesis by modulating CDC42 acetylation.
Article
Pharmacology & Pharmacy
Xiaocong Xiang, Yunhong Tian, Jiani Hu, Rong Xiong, Matthew Bautista, Li Deng, Qiuju Yue, Yuqi Li, Wei Kuang, Junfeng Li, Kang Liu, Chunlei Yu, Gang Feng
Summary: Fangchinoline (Fan) induces apoptosis and autophagy in colorectal cancer cells by activating the AMPK/mTOR/ULK1 signaling pathway, inhibiting tumor growth both in vitro and in vivo, and showing potential as a promising anticancer agent.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yu Gan, Xiaoying Li, Shuangze Han, Li Zhou, Wei Li
Summary: This study confirmed the inhibitory effect of bergenin on colorectal cancer cells both in vivo and in vitro. Bergenin significantly reduced the viability and colony formation of CRC cells, and promoted apoptosis. Bergenin inhibited the Akt/GSK3 beta signaling and promoted the interaction between FBW7 and Mcl-1, resulting in the ubiquitination and degradation of Mcl-1. In vivo studies showed that bergenin reduced tumor size and weight without toxicity to vital organs in mice.
Article
Chemistry, Medicinal
Xiang Lu, Chaoran Zhu, Chongwei Zhang, Xiujun Li, Zhenqiang Yu, Zhenzhong Zhang, Xiufang Shi
Summary: In this study, scopoletin derivatives were synthesized and evaluated for their antiproliferative activity against four cancer cell lines. Compound 5c showed the highest potency with improved activity compared to the parental scopoletin.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Junshan Wang, Zhixuan Ding, Wei Shu, Ying Zhuge
Summary: This study reveals that kinetochore-associated protein 1 (KNTC1) plays a crucial role in the genesis and progression of colorectal cancer. Inhibition of KNTC1 can suppress proliferation, cell cycle and migration of colorectal cancer cells, while promoting apoptosis. Therefore, KNTC1 may serve as an early diagnostic indicator of precancerous lesions.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Xiaojing Fu, Wenwen Zhao, Kangkang Li, Jingyi Zhou, Xuehong Chen
Summary: The study reveals the anticancer effects of cryptotanshinone (CPT) in colorectal cancer (CRC) by activating autophagy signaling mediated by ER stress. CPT selectively inhibits the growth and proliferation of HCT116 and SW620 cells while having little effect on SW480 cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Hariprasad Thangavel, Kezia Lizardo, Dhanya Dhanyalayam, Sonia De Assis, Jyothi F. Nagajyothi
Summary: Breast cancer is one of the most diagnosed cancer types, and the association between obesity and breast cancer risk varies by age. A short-term high-fat diet delays tumorigenesis, while a regular diet may increase tumor occurrence and metastasis in young mice. It suggests that the pathogenesis of breast cancer is regulated by diet composition, adipogenesis, and loss of body fat, which differs between young and post-menopausal subjects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Xiaoming Zhao, Tianzhuo Sui, Zhendong Fu, Leichao Zhang, Yiyao Gao, Liping Wang, Hui Zhang
Summary: Taisui, a functional food with rich medicinal value in ancient Chinese books, has shown potential as an anticancer agent for colorectal cancer. It inhibits cancer cell proliferation by inducing S-phase arrest, apoptosis, and autophagy, while regulating related proteins. Taisui fermentation broth induces apoptosis and autophagy in HCT116 cells by regulating reactive oxygen species-mediated JNK/p38 signaling. In addition, it inhibits tumor growth in a mouse xenograft model.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Ainaz Mihanfar, Saber Ghazizadeh Darband, Shirin Sadighparvar, Mojtaba Kaviani, Mohammad Mirza-Aghazadeh-Attari, Bahman Yousefi, Maryam Majidinia
Summary: This study demonstrates the inhibitory effects of syringic acid on proliferation and induction of apoptosis in human colorectal cancer cells, as well as its reduction of tumor volume and incidence in a rat model of colorectal cancer.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Hee Dong Jeon, Yo-Han Han, Jeong-Geon Mun, Dae Hwan Yoon, Yeong Gyeong Lee, Ji-Ye Kee, Seung-Heon Hong
Summary: The study found that dehydroevodiamine (DHE) has potential therapeutic effects on lung metastasis of colorectal cancer (CRC) and proliferation of CRC cells. DHE suppresses cell viability, induces apoptosis and autophagy, and regulates cell migration and invasion.
