Article
Biophysics
Keyi Luo, Hang Wu, Yongkang Chen, Jinfeng Li, Lingling Zhou, Fan Yang, Mingxian Huang, Xiao An, Shige Wang
Summary: Radiotherapy is a common treatment for cancer, but tumors with a hypoxic environment often show resistance to it, leading to potential recurrence and metastasis. Therefore, strategies to enhance radiotherapy efficiency are crucial for effective cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Sung-Won Shin, Kyungmi Yang, Miso Lee, Jiyoung Moon, Arang Son, Yeeun Kim, Suha Choi, Do-hyung Kim, Changhoon Choi, Nohyun Lee, Hee Chul Park
Summary: The study found that MFN may overcome radioresistance by alleviating hypoxia and enhancing antitumor immunity in the tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Haijun Wang, Dianlong Jia, Dandan Yuan, Xiaolei Yin, Fengjiao Yuan, Feifei Wang, Wenna Shi, Hui Li, Li-Min Zhu, Qing Fan
Summary: This study presents a novel approach for translational tumor theranostics by integrating Her2 targeting, diagnosis, and RT sensitization into a single platform using nanocarriers. The developed nanoparticles demonstrated biodegradability and localized production of O-2 in a simulated tumor microenvironment, efficiently inhibited tumor growth, and improved radiosensitization. The incorporation of Z(Her2) endowed these nanoparticles with Her2-dependent binding ability and effective tumor homing and penetration, highlighting their potential for precise enhanced chemo-radiotherapy of Her2-positive ovarian tumors.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Wei Qian, Shi Zhang, Chuan Tong, Jordi Sardans, Josep Penuelas, Xiaofei Li
Summary: This study summarizes the dissolved oxygen concentrations in northwestern and southern Hong Kong as well as Mirs Bay over the past three decades and analyzes the crucial factors driving hypoxia in these areas. The results suggest that local productivity and water stratification are the main drivers of hypoxia formation and maintenance.
JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yilin Wan, Lian-Hua Fu, Chunying Li, Jing Lin, Peng Huang
Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Yi Pan, Longcai Liu, Xiaozhou Mou, Yu Cai
Summary: Cancer is a major disease with complex pathological processes that greatly affect human welfare. Hypoxia, caused by an imbalance between oxygen supply and consumption, is a natural characteristic of most solid tumors and a significant obstacle for cancer therapy. Various strategies have been developed to exploit tumor hypoxia, including alleviating hypoxia and utilizing it for targeted delivery and diagnostic imaging. Nanomedicine strategies have shown promising progress in both conquering and utilizing hypoxia to combat cancer, and the development of emerging nanomaterials holds potential for future clinical translation.
Article
Chemistry, Multidisciplinary
Zhenbang Cao, Liang Zhang, Jianxin Liu, Dong Wang, Kang Liang, Yu Chen, Zi Gu
Summary: A dual enzyme-mimicking radical generator has been developed to enhance the efficacy of photodynamic therapy by in situ generation of oxygen and radical oxygen species. The metal organic framework-based radical generator nanoparticles exhibit catalase-like and peroxidase-like activities specifically at the tumor microenvironment, leading to increased reactive oxygen species levels and improved anti-cancer effects.
Article
Medicine, Research & Experimental
Meng Lyu, Mingzhu Chen, Lujie Liu, Daoming Zhu, Xianjia Wu, Yang Li, Lang Rao, Zhirong Bao
Summary: This study developed a biomimetic nanotheranostic platform to enhance the efficacy of interstitial brachytherapy (BT) for cancer. By utilizing the targeting capabilities of nanoparticles, the treatment successfully evaded immune clearance and specifically accumulated in tumor tissues, resulting in improved therapeutic outcomes.
Review
Biochemistry & Molecular Biology
Liang Hong, Jiangmin Li, Yali Luo, Tao Guo, Chenshuang Zhang, Sha Ou, Yaohang Long, Zuquan Hu
Summary: This review summarizes the latest strategies for overcoming hypoxia in tumor photodynamic therapy (PDT), categorizing them into oxygen-independent phototherapy, oxygen-economizing PDT, and oxygen-supplementing PDT. The strengths, shortcomings, opportunities, and challenges of different methods are analyzed.
Article
Chemistry, Multidisciplinary
Zhiwan Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yaping Li, Xianyi Sha, Zhiwen Zhang
Summary: This study presents an amphiphilic F-11-derivative-based oxygen-delivering polyfluorocarbon nanovehicle for cancer therapy, aiming to relieve tumor hypoxia and boost antitumor immunity. The optimized PF(11)DG nanovehicles showed enhanced tumor oxygenation and significant inhibition of tumor growth in breast and pancreatic cancer models, indicating promising therapeutic benefits.
Article
Chemistry, Multidisciplinary
Jie Wang, Fernando Soto, Shiqin Liu, Qingqing Yin, Emma Purcell, Yitian Zeng, En-Chi Hsu, Demir Akin, Bob Sinclair, Tanya Stoyanova, Utkan Demirci
Summary: In this study, an all-in-one self-propelled volvox-based multifunctional robot, named Volbot, was developed with built-in capabilities of fluid mixing, multimode imaging, and photosynthesis-mediated in situ oxygen generation. Volbots can follow a pre-specified route and directionality under the control of a magnetic field. The findings suggest that Volbots hold considerable promise as a multifunctional microrobotics-based theranostic approach for a precision tumor therapy strategy.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Yu Chong, Jiayu Ning, Shengyi Min, Jiaquan Ye, Cuicui Ge
Summary: Radiotherapy is an important treatment for malignant tumors, but tumor resistance and damage to healthy tissues limit its efficacy. Developing novel radioenhancers and radioprotectants is crucial for improving clinical radiotherapy. Nanozymes have shown great potential in radiation medicine due to their multi-enzyme activities and microenvironment-responsive feature. This review systematically illustrates the progress of nanozymes in potentiating radiotherapy and radiation protection, including promoting reactive oxygen species generation, relieving tumor hypoxia, and preventing radiation-induced damage.
CHINESE CHEMICAL LETTERS
(2022)
Article
Engineering, Biomedical
Rong Chai, Luodan Yu, Caihong Dong, Yipengchen Yin, Sheng Wang, Yu Chen, Qin Zhang
Summary: In this study, a biomimetic radiosensitized platform based on a natural in-situ oxygen-evolving photosynthetic cyanobacteria combined with a high atomic-number two-dimensional (2D) bismuthene is designed and engineered to effectively modulate the radiotherapy-resistant hypoxic tumor environment and achieve sufficient radiation energy deposition into tumor. This platform shows enhanced therapeutic efficacy of radiotherapy and suppressed tumor growth, demonstrating the potential of microorganism-enabled tumor-microenvironment modulation and nanoradiosensitizer-augmented radiotherapy for efficient tumor treatment.
BIOACTIVE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Xianqiang Li, Yue Wu, Rui Zhang, Wei Bai, Tiantian Ye, Shujun Wang
Summary: Oxygen-based nanocarriers play a crucial role in enhancing anti-tumor therapy by increasing oxygen concentration in hypoxic tumor areas. Despite the potential benefits, there are still challenges and limitations that need to be addressed for improving targeting ability and clinical translation in the future.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Green & Sustainable Science & Technology
Kokouvi Edem N'Tsoukpoe, Frederic Kuznik
Summary: This paper focuses on the challenges and questioning of long-term thermochemical heat storage for household applications, highlighting the significant thermal losses in seasonal thermochemical storage. The study suggests that the energy storage density based on solid hydrates or aqueous solutions may not be practical for long-term thermal energy storage for domestic hot water and heating.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
