Article
Chemistry, Multidisciplinary
James E. Tyrrell, Martyn G. Boutelle, Alasdair J. Campbell
Summary: OECTs have proven to be successful in transducing physiological information and measuring high-frequency signals, with significant improvements in key performance parameters like peak transconductance and response time.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
James E. Tyrrell, Konstantinos Petkos, Emmanuel M. Drakakis, Martyn G. Boutelle, Alasdair J. Campbell
Summary: This study explores the potential and advantages of OECT amplifiers in bioelectronics by implementing high-performance interdigitated electrode OECTs. By determining the stability of performance parameters through variations in OECT geometries and conducting simulations and physical measurements, the study demonstrates the superior performance of OECT amplifiers in transducing and amplifying physiological signals.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Ali Nawaz, Qian Liu, Wei Lin Leong, Kathryn E. Fairfull-Smith, Prashant Sonar
Summary: Organic electrochemical transistors (OECTs) are a focus of intense research with great potential in expanding the horizons of the bioelectronics industry. Their unique characteristics, such as electrolyte-gating and aqueous stability, make them particularly suitable for in vivo applications. OECTs form a soft mechanical contact with the biological milieu, ensuring a high signal-to-noise ratio and amplification capability, making them desirable for a wide range of in vivo applications.
ADVANCED MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Adam Marks, Sophie Griggs, Nicola Gasparini, Maximilian Moser
Summary: Recent research has shown the potential of organic electrochemical transistors (OECTs) as a promising technology for biosensors. This comprehensive summary highlights the significant progress and notable advances in OECT-based biosensors, detailing their working principles and current channel materials. The article also discusses the applications of OECTs in various sensing fields and provides insights into future channel material design.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Myriam Abarkan, Antoine Pirog, Donnie Mafilaza, Gaurav Pathak, Gilles N'Kaoua, Emilie Puginier, Rodney O'Connor, Matthieu Raoux, Mary J. Donahue, Sylvie Renaud, Jochen Lang
Summary: Electrical signals are crucial for key biological events and organic electrochemical transistors (OECTs) have demonstrated their ability to accurately capture neuronal and cardiac signals. Vertical PEDOT:PSS-based OECTs (vOECTs) enhance signal amplification and device density, expanding their potential applications in biomedical fields.
Article
Materials Science, Multidisciplinary
Dimitrios A. Koutsouras, Katharina Lieberth, Fabrizio Torricelli, Paschalis Gkoupidenis, Paul W. M. Blom
Summary: The fabrication approach demonstrated in this study involved integrated devices consisting of two electrochemical transistors, capable of selective simultaneous detection between potassium and sodium ions in an analyte. This versatile approach enables the fabrication of micro-scale ion sensors for biomedical applications and can be extended to include numerous ion-selective transistors on a chip to meet the demand for simultaneous sensing of multiple ions.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Materials Science, Multidisciplinary
Trong Danh Nguyen, Tran Quang Trung, Yurim Lee, Nae-Eung Lee
Summary: The study introduces a highly stable and stretchable synaptic OECT fabricated on a 3D mogul-patterned substrate with improved synaptic properties by enhancing the mechanical stability of the PEDOT:PSS channel and the OECT through the addition of additives, as well as tuning and improving synaptic properties by introducing a Nafion membrane between the channel and the gate electrode to modify ion transport dynamics in the electrolyte.
ADVANCED ENGINEERING MATERIALS
(2022)
Review
Chemistry, Analytical
Cailing He, Mengdan Tao, Chenxi Zhang, Yifang He, Wei Xu, Yan Liu, Wanying Zhu
Summary: Dopamine is an essential neurotransmitter in the central nervous system and its abnormal metabolism is related to various diseases. Electrochemical sensing technology, particularly with microelectrodes, is recognized as the most effective method for measuring neurotransmitters in vivo. This article reviews recent applications and research on microelectrodes for dopamine detection in vivo, highlighting the advantages of high sensitivity and spatial resolution.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Dong Un Lim, Sae Byeok Jo, Jeong Ho Cho
Summary: Organic electrochemical transistors (OECTs) are a promising candidate for printable electronics, offering chemical versatility and a unique redox-based operating principle. This study presents a simple strategy to achieve monolithic multi-valued logic transistors, an important branch of transistor technology. The introduction of a vertically stacked heterogenous dual-channel architecture and patterned reference electrode enables the manifestation of stable ternary logic states with reduced transistor footprint. The dual-ion-penetration mechanism and ultrashort vertical channel also allow for high-frequency accessing of multiple logic states.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Roberto Granelli, Ivano Alessandri, Paschalis Gkoupidenis, Irene Vassalini, Zsolt M. Kovacs-Vajna, Paul W. M. Blom, Fabrizio Torricelli
Summary: This study proposes fully printed mask-less OECTs fabricated on thin-film biodegradable and compostable substrates, enabling monolithic integration of high-performance bioelectronics.
Article
Materials Science, Multidisciplinary
Sin Yu Yeung, Asmita Veronica, Yue Li, I-Ming Hsing
Summary: This study comprehensively investigates the structural and functional properties of ion-embedded PEDOT:PSS modified by different annealing temperatures, and correlates them to the performance of the IGT. The results show that short-time high-temperature annealing treatment improves the film's conductivity and hole mobility, leading to enhanced performance of the IGT.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
Reem B. Rashid, Austin M. Evans, Lyndon A. Hall, Raghunath R. Dasari, Emily K. Roesner, Seth R. Marder, Deanna M. D'Allesandro, William R. Dichtel, Jonathan Rivnay
Summary: Organic electrochemical transistors (OECTs) have great potential in bioelectronic sensing, circuits, and neuromorphic hardware. The use of organic mixed ionic/electronic conductors (OMIECs) as the active channel allows for precise control of electronic and ion transport. Two-dimensional polymers (2DPs) offer new opportunities to control OECT performance by providing well-defined channels for ion transport.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Marc Clua Estivill, Adil Ait Yazza, Pascal Blondeau, Francisco J. Andrade
Summary: This study presents the development and optimization of a paper-based ion-selective organic electrochemical transistor (IS-OECT) with remarkable analytical performance. The device combines thick-film transistor technology, optimal ion-selective membrane composition and thickness to achieve high sensitivities and good selectivity for detecting potassium concentrations in blood.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Review
Materials Science, Multidisciplinary
Henrique Teixeira, Catarina Dias, Paulo Aguiar, Joao Ventura
Summary: The research has uncovered a new class of high aspect ratio gold-mushroom microelectrode arrays (GM mu EAs) that can be used for long-term recording of neuronal signals and enhancing the cell-microelectrode interface, addressing the issue of low sensitivity of traditional MEAs to sub-threshold neuronal signals. These devices show promising development prospects, serving not only as an electrophysiological tool but also playing a role in applications such as plasmonics.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Physics, Multidisciplinary
Alain Boldini, Youngsu Cha, Maurizio Porfiri
Summary: This study demonstrates a novel principle of contactless actuation for ionic membranes in salt solution based on solvation, showing a strong dependence of membrane deflection on the hydration numbers of mobile ions. It suggests a critical role of solvation in the chemoelectro-mechanics of natural and artificial selectively permeable membranes.
PHYSICAL REVIEW LETTERS
(2021)
Article
Engineering, Biomedical
Changho Chun, Alec S. T. Smith, Hyejin Kim, Dana S. Kamenz, Jung Hyun Lee, Jong Bum Lee, David L. Mack, Mark Bothwell, Claire D. Clelland, Deok-Ho Kim
Summary: This study investigated the impact of astrocyte-derived extracellular vesicles (EVs) on human neurons cultured in vitro, demonstrating that these EVs can enhance the electrophysiological function and anti-apoptotic behavior of neurons. The cargo proteins found in the EVs include various neuroprotective proteins and proteins that positively regulate neuronal excitability and synaptic development, suggesting the potential for EV-based therapeutics in treating neuropathies.
Article
Engineering, Biomedical
Jonathan H. Tsui, Andrea Leonard, Nathan D. Camp, Joseph T. Long, Zeid Y. Nawas, Rakchanok Chavanachat, Alec S. T. Smith, Jong Seob Choi, Zhipeng Dong, Eun Hyun Ahn, Alejandro Wolf-Yadlin, Charles E. Murry, Nathan J. Sniadecki, Deok-Ho Kim
Summary: Hybrid hydrogels composed of decellularized porcine myocardial extracellular matrix (dECM) and reduced graphene oxide (rGO) were developed to improve the functionality of cardiomyocytes. These hydrogels can also be used as bioinks to print cardiac tissues in a high-throughput manner. Modulating the composition and properties of the materials can enhance the electrophysiological function of cardiac tissues.
Article
Polymer Science
Yeon Jae Kim, Deok-Ho Kim, Jong Seob Choi, Jin-Heong Yim
Summary: Fabrication methods for 3D soft and flexible gas/strain sensing materials were investigated in this study. Electrically modifying 3D-printed soft thermoplastic polyurethane (TPU) with polypyrrole (PPy) led to excellent electrical strain sensing behavior and stability. The modified TPU also showed great potential as an ammonia gas sensor.
Article
Chemistry, Multidisciplinary
Tatsuya Matsubara, Jong Seob Choi, Deok-Ho Kim, Joon-Wan Kim
Summary: This paper proposes a microsyringe pump that utilizes the interface between water and oil, as well as ECF-driven electrohydrodynamic flow, to withdraw and infuse aqueous solution. By integrating ECF-driven leakless on/off microvalves, the system can accurately control the flow direction and rate.
Article
Cell Biology
Alec S. T. Smith, Changho Chun, Jennifer Hesson, Julie Mathieu, Paul N. Valdmanis, David L. Mack, Byung-Ok Choi, Deok-Ho Kim, Mark Bothwell
Summary: Gene editing technologies can enhance modeling of inheritable neurodegenerative diseases, but careful comparison of multiple cell lines is needed to ensure consistency and accuracy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Alec S. T. Smith, Jong Hyun Kim, Changho Chun, Ava Gharai, Hyo Won Moon, Eun Young Kim, Soo Hyun Nam, Nina Ha, Ju Young Song, Ki Wha Chung, Hyun Myung Doo, Jennifer Hesson, Julie Mathieu, Mark Bothwell, Byung-Ok Choi, Deok-Ho Kim
Summary: This study used human induced pluripotent stem cell models to investigate CMT2D disease, finding significant neuronal activity defects in cells with GARS1 mutations, and treatment with histone deacetylase 6 inhibitor CKD504 can improve these defects.
Article
Multidisciplinary Sciences
Dylan Shea, Elizabeth Colasurdo, Alec Smith, Courtnie Paschall, Suman Jayadev, C. Dirk Keene, Douglas Galasko, Andrew Ko, Ge Li, Elaine Peskind, Valerie Daggett
Summary: The formation of toxic Amyloid beta-peptide oligomers is an early event in Alzheimer's Disease. A designed alpha-sheet peptide can inhibit the deleterious effects on neuronal signaling and serve as a capture agent in a soluble oligomer binding assay. This method can detect toxic oligomers in Alzheimer's Disease and discriminate them from other forms of dementia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Electrical & Electronic
Taiki Otomo, Tatsuya Matsubara, Kazuhiro Yoshida, Deok-Ho Kim, Masashi Ikeuchi, Joon-wan Kim
Summary: This study proposes a microfluidic device that uses MEMS-fabricated micro-pumps to apply stretch stimulation to cells in order to mimic the in vivo environment of organs. The device successfully stretches a microporous membrane with similar frequency and strain as the organs' in vivo environment, demonstrating its potential for efficient and effective drug discovery screening.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Materials Science, Biomaterials
Chia-Yi Su, Tatsuya Matsubara, Alex Wu, Eun Hyun Ahn, Deok-Ho Kim
Summary: Cells detached from collectively migrating cells are frequently found during tumor invasion at the invasion front, where extracellular matrix fibers are parallel to the cell migration direction. It remains unclear how anisotropic topography promotes the transition of collective to disseminated cell migration.
Article
Cell & Tissue Engineering
Alec S. T. Smith, Shawn M. Luttrell, Jean-Baptiste Dupont, Kevin Gray, Daniel Lih, Jacob W. Fleming, Nathan J. Cunningham, Sofia Jepson, Jennifer Hesson, Julie Mathieu, Lisa Maves, Bonnie J. Berry, Elliot C. Fisher, Nathan J. Sniadecki, Nicholas A. Geisse, David L. Mack
Summary: Engineered muscle tissues combined with a magnetic sensing system allow non-invasive longitudinal analysis of developing contraction kinetics, improving research efficiency and drug screening capabilities. The platform enables identification and classification of healthy and diseased muscle cells, and has significant implications for the translation of novel therapies.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Jong Seob Choi, Byunggik Kim, Gwangjun Go, Deok-Ho Kim
Summary: A nanopatterned PEDOT:Nafion composite layer integrated with interdigitated electrodes was developed to enhance the device performance for cellular impedance spectroscopy. The mixing ratio of PEDOT and Nafion was found to affect the cellular alignment and the electrical characteristics of the composite. Computational modeling demonstrated the electrical current flow and density in the composite at different frequency ranges. These findings highlight the potential of using an electrically modified Nafion nanopattern interface with interdigitated electrodes for impedance-based cellular biosensors in a more biomimetic and sensitive manner.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Yeon Jae Kim, Jong Seob Choi, Jin-Heong Yim
Summary: This study investigates the effects of different infill patterns on the mechanical and electrical properties of TPU and conductive TPU composites. The rhombus infill pattern showed a more uniform stress distribution, which contributed to reduced cracking and defect formation under repetitive stress. Additionally, the different infill patterns also influenced the performance of strain sensors and ammonia gas sensors.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Materials Science, Multidisciplinary
Jin Seul Park, Hoe Jin Kang, Byong Taek Lee, Jong Seob Choi, Jin-Heong Yim
ACS APPLIED POLYMER MATERIALS
(2020)
