Article
Environmental Sciences
Jiajing Cui, Pingwei Wang, Shuqi Yan, Yujun Liang, Dongge Liu, Shuping Ren
Summary: The study aims to explore the role of ferroptosis in endothelial cell dysfunction and its underlying mechanisms.
Article
Environmental Sciences
Guiyi Gong, Hiotong Kam, Yubin Bai, Wai San Cheang, Shuilong Wu, Xiaoning Cheng, John P. Giesy, Simon Ming-yuen Lee
Summary: This study reveals that 6-benzylaminopurine (6-BA) has adverse effects on human-derived cells and zebrafish endothelial system, potentially posing risks to the cerebral vascular system through its impact on the MAPK signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pablo C. Caracciolo, Patricia Diaz-Rodriguez, Ines Ardao, David Moreira, Florencia Montini-Ballarin, Gustavo A. Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The study developed bioresorbable small-diameter vascular grafts functionalized with heparin to promote endothelial cell growth and inhibit smooth muscle cells over-proliferation. The tensile properties of the heparin-functionalized vascular grafts resembled those of saphenous veins, indicating potential clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biotechnology & Applied Microbiology
Hui Kang, Hui Yu, Jingxiu Fan, Ge Cao
Summary: Rotigotine shows beneficial effects on Ox-LDL-induced endothelial cell damage, including inhibition of cholesterol accumulation, improvement of monocyte adhesion, reduction of oxidative stress and inflammation. Its potential therapeutic role in cardiovascular diseases is highlighted through these effects.
Article
Cell Biology
Sandra Dienemann, Vanessa Schmidt, Tabea Fleischhammer, Julia H. H. Mueller, Antonina Lavrentieva
Summary: In vitro cultivation conditions are important for understanding cell physiology and responses to external stimuli. Oxygen concentrations are crucial in influencing cell behaviors in both 2D and 3D cultures. This study genetically modified two types of human endothelial cells and monitored their responses to different oxygen concentrations. The findings demonstrated different hypoxic signatures for these cells in both 2D and 3D culture systems.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Da-Qiang Song, Jiao Liu, Fang Wang, Xiao-Fang Li, Ming-Hua Liu, Zhuo Zhang, Shou-Song Cao, Xian Jiang
Summary: PB2 pretreatment significantly reduced LPS-induced cytotoxicity and apoptosis in HUVECs, and modulated the expression levels of IL-1 beta, IL-6, TNF-alpha, Bax, cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, etc. PB2 may exert its effects through the Bax/Bcl-2 and NF-kappa B signaling pathways, providing potential therapeutic benefits for infectious vascular diseases.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Nutrition & Dietetics
Na Zhu, Xinran Liu, Meihong Xu, Yong Li
Summary: The study found that dietary nucleotides can delay HUVECs senescence induced by oxidative stress, with GMP100 exhibiting the best effect. The mixture of nucleotides plays a comprehensive role in delaying HUVECs senescence, possibly related to its antioxidant and anti-inflammatory properties.
Article
Biotechnology & Applied Microbiology
Yunxin Zhang, Jianlong Liu, Wei Jia, Xuan Tian, Peng Jiang, Zhiyuan Cheng, Jinyong Li
Summary: The study aimed to identify the roles of AGE/RAGE and ET-1 in deep vein thrombosis (DVT). Blocking AGE/RAGE pathway was found to mitigate HUVEC damage in DVT by improving cell viability, reducing apoptosis, alleviating inflammatory cytokine release, oxidative stress, and downregulating the expression of certain proteins.
Article
Pharmacology & Pharmacy
Lin Che, Zi-Li Wu, Lian-Yun Huang, Jia-Shen Wu, Ze-Bang Du, Jin-Xian Lin, Yan-Hua Su, Xiao-Xuan Chen, Zhong-Ning Lin, Yu-Chun Lin
Summary: The study elucidates the mechanism by which cadmium pollutants affect vascular health, highlighting the importance of regulating the expression of the COX-2 gene in patients with cardiovascular diseases to mitigate the adverse effects caused by cadmium exposure.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Jinpeng Wang, Yue Wang, Yuyi Zhao, Jinbin Zhao, Beilin Zhang, Kun Xu
Summary: This study demonstrated that EGCG inhibits proliferation, induces apoptosis, and up-regulates genes associated with cell apoptosis and autophagy in HUVECs grown on 316L stainless steel, suggesting its potential as a novel drug for stent implantation.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Toxicology
Xudong Liu, Yuchao Zhang, Liangyu Liu, Sijie Zhu
Summary: The study showed that ethanol could induce systemic effects and alter signaling pathways in HUVECs.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lifang Chen, Chenxu Shang, Bo Wang, Guan Wang, Zhen Jin, Feng Yao, Zejun Yue, Liang Bai, Rong Wang, Sihai Zhao, Enqi Liu, Weirong Wang
Summary: The study revealed that HDAC3 inhibitor suppresses EndMT in both ApoE / mice and HUVECs by modulating inflammatory response, thus significantly impacting the formation of atherosclerotic plaques.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingmei Luo, Xuefeng Wang, Yi Cao
Summary: The study found that the cytotoxicity of graphene oxide (GO) on human umbilical vein endothelial cells (HUVECs) is related to impaired lipid droplet biogenesis, with the size of GO and lipid metabolism pathways also influencing its cytotoxicity. GO-L induced more significant cytotoxicity, while GO-S had a greater impact on KEGG pathways related to lipid metabolism.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Food Science & Technology
Ho-Jeong Bang, Eunju Yoon, Sun Wook Kim, Mok-Ryeon Ahn
Summary: Benzyl caffeate significantly inhibits angiogenesis by inducing apoptosis and anti-proliferative effects on endothelial cells, showing potential antiangiogenic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)