Prevention of Bacterial Colonization Based on Self-Assembled Metal-Phenolic Nanocoating from Rare-Earth Ions and Catechin

Clinically related infection is a critical risk for human health and is usually caused by biofilm formation on medical devices. Herein, typical polyphenols, catechin (Cat), and rare-earth ions (Re3+) were used for self-assembled Cat-Re nanoparticles that can be facilely coated on the surface of a polyamide (PA) membrane to synergistically prevent bacterial adhesion and subsequent biofilm formation. The antibacterial adhesion feature of the assembled Cat-Re nanoparticles coated on the PA membrane surface was assessed using Pseudomonas aeruginosa, one of the most common pathogenic bacteria, as probe bacteria under static and dynamic simulation flow conditions. The Cat-Re nanocoating showed excellent antibacterial and anti-adhesion activities against P. aeruginosa and successfully prevented biofilm formation on the material's surface. Regardless of the conditions, the Cat-Re nanocoating significantly suppressed the growth and attachment of P. aeruginosa and maintained >90% inhibition activity with favorable reusability and long-term stability. The results suggest that the self-assembled rare-earth-phenolic nanocoating has promising application potential in the prevention of medical device-related biofilm formation.