Review
Cell Biology
Alin Garcia-Miranda, Alejandra Garcia-Hernandez, Eduardo Castaneda-Saucedo, Napoleon Navarro-Tito, Paola Maycotte
Summary: Excess body weight and obesity have been identified as significant risk factors for cancer development, with adipokines playing a crucial role in promoting an inflammatory microenvironment conducive to carcinogenesis and tumor progression. Autophagy, a process implicated in both tumor suppression and cancer progression, has been suggested as a therapeutic target in cancer treatment, with its effectiveness potentially influenced by tumor type and microenvironmental conditions influenced by circulating adipokines.
Article
Biochemistry & Molecular Biology
Sevdalina Nikolova Lambova, Tsvetelina Batsalova, Dzhemal Moten, Stela Stoyanova, Elenka Georgieva, Lyudmila Belenska-Todorova, Desislava Kolchakova, Balik Dzhambazov
Summary: Obesity is a major risk factor for the development and progression of knee osteoarthritis (OA). The levels of leptin and resistin are higher in knee OA patients, especially those with high BMI. This study suggests a possible link between obesity, leptin, resistin, and OA pathogenesis.
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Lourdes Hontecillas-Prieto, Daniel J. Garcia-Dominguez, Fernando Zapata, Natalia Palazon-Carrion, Maria L. Sanchez-Leon, Malika Tami, Antonio Perez-Perez, Flora Sanchez-Jimenez, Teresa Vilarino-Garcia, Luis De la Cruz-Merino, Victor Sanchez-Margalet
Summary: Obesity is considered a pandemic and a risk factor for various types of cancers, including lymphoma, due to its promotion of an inflammatory state. Leptin, as a key adipokine, has been studied for its potential role in connecting obesity and lymphomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Georgios-Ioannis Verras, Levan Tchabashvili, David-Dimitris Chlorogiannis, Francesk Mulita, Maria-Ioanna Argentou
Summary: Breast cancer is a common and deadly disease, with obesity and hormonal changes being known risk factors. Adipokines, which are molecules related to fatty tissue, play a key role in these hormonal changes and have been linked to breast cancer development. This review aims to summarize the evidence and highlight the potential of adipokines as biomarkers, predictive indicators, and therapeutic targets for breast cancer.
Article
Geriatrics & Gerontology
Sanne S. Mooldijk, Mohammad Kamran Ikram, Mohammad Arfan Ikram
Summary: This study examined the association between plasma levels of adiponectin, leptin, and resistin with the risk of dementia. The results showed that higher levels of leptin and resistin were associated with a decreased risk of dementia, while adiponectin levels were not associated.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Wenhao Lu, Wenjie Feng, Jieyu Lai, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
Summary: Sarcopenia is an age-related disease characterized by decreases in muscle mass, strength, and function, and an increase in body fat content, particularly visceral fat. Adipose tissue secretes adipokines, which have regulatory effects on muscle. For example, high levels of leptin decrease muscle function, while adiponectin inhibits muscle atrophy-related genes to prevent muscle mass loss. This article discusses the effects of adipokines such as leptin, adiponectin, resistin, mucin, and lipocalin-2 on muscle and their importance in understanding sarcopenia development.
CHINESE MEDICAL JOURNAL
(2023)
Article
Health Care Sciences & Services
Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O'haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
Summary: The study found significantly altered concentrations of four adipokines, adiponectin, leptin, visfatin and chemerin, in the T2DM patient group compared to the controls, with more pronounced alterations in the obese and highly obese patients. This suggests that these four adipokines play a significant role in the onset, progression, and associated complications of T2DM. More research on a larger sample size is needed to further explore the relationship between adipokines and T2DM.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Cell Biology
Talitha Abraham, Andrea M. P. Romani
Summary: Obesity has been on the rise in the US and globally, with the prevalence increasing by 2% per decade since 1975. Maternal obesity rates have also increased worldwide, leading to obstetric complications such as gestational diabetes, high blood pressure, and pre-eclampsia. This literature review aims to explore the relationship between obesity and predictive biomarkers for pre-eclampsia in order to improve future prediction and prevention of the condition in at-risk women.
Article
Virology
Mao-Seng Zeng, Wen-Di Yu, Hui-Xian Wang, Pei-Ping Xu, Jin-Yuan Liu
Summary: The study showed that puerarin can reverse the impairment of intestinal and adipose immune responses caused by influenza virus infection.
ARCHIVES OF VIROLOGY
(2021)
Article
Oncology
Emanuele Vita, Alessio Stefani, Geny Piro, Luca Mastrantoni, Marco Cintoni, Giuseppe Cicchetti, Ileana Sparagna, Federico Monaca, Guido Horn, Jacopo Russo, Diletta Barone, Mariantonietta Di Salvatore, Rocco Trisolini, Filippo Lococo, Ciro Mazzarella, Alessandra Cancellieri, Carmine Carbone, Anna Rita Larici, Maria Cristina Mele, Sara Pilotto, Michele Milella, Giampaolo Tortora, Emilio Bria
Summary: Leptin may play a crucial role in the effectiveness of immunotherapy in lung adenocarcinoma, and is associated with metabolic immune dysfunctions.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Medicine, General & Internal
Felipe Mattioni Maturana, Rebecca Rolf, Simone Schweda, Max Reimer, Manuel Widmann, Christof Burgstahler, Andreas M. Niess, Inga Krauss, Barbara Munz
Summary: Physical exercise has positive effects on chronic conditions, and leptin may serve as a suitable biomarker in exercise-based lifestyle intervention programs for subjects with multimorbidity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Klaudia Parafiniuk, Wiktoria Skiba, Anna Pawlowska, Dorota Suszczyk, Aleksandra Maciejczyk, Iwona Wertel
Summary: The relationship between obesity and epithelial ovarian cancer (EOC) remains inconclusive. The adipokine hypothesis suggests that adipocytes in obese individuals interact with cancer cells and promote their migration and metastasis through the secretion of adipokines, growth factors, and hormones. Resistin, one of the adipokines, has been found to stimulate the growth and differentiation of ovarian cancer cells, increase angiogenesis factors, induce epithelial-mesenchymal transition (EMT), and affect survival in EOC patients.
Article
Biochemistry & Molecular Biology
Katarzyna Madra-Gackowska, Karolina Szewczyk-Golec, Marcin Gackowski, Alina Wozniak, Kornelia Kedziora-Kornatowska
Summary: The objective of this study was to identify potential biomarkers of malnutrition in hospitalized older patients. Selected parameters of oxidative stress and adipokines were determined in 137 senile patients, and leptin and resistin were found to have statistically significant differences between patients classified according to the Mini Nutritional Assessment (MNA) and Geriatric Nutritional Risk Index (GNRI). Additional parameters showing differences included oxidized low-density lipoprotein level and activity of glutathione peroxidase. These markers could be suggested for early risk identification and personalized nutritional therapy in hospitalized senile patients.
Article
Multidisciplinary Sciences
Andrea Marcinno, Erica Gallo, Fausto Roveta, Silvia Boschi, Alberto Grassini, Innocenzo Rainero, Elisa Rubino
Summary: This study investigated the expression of adiponectin, leptin, and resistin in Alzheimer's disease (AD) and Frontotemporal Dementia (FTD). The results showed that lower resistin concentrations were associated with an increased risk of dementia, particularly in AD. The study suggests that the resistin-linked metabolic profile should be further investigated in AD.
Article
Veterinary Sciences
Michal Mazaki-Tovi, Omer Shachar, Tzachi Even Zur
Summary: Hypothyroidism in dogs is associated with altered serum concentrations of visfatin and betatrophin, and these alterations can be partially resolved with thyroxine treatment.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Vitaly A. Bekenev, Sergey N. Mager, Anatoly A. Arishin, Olga G. Merzlyakova, Elena V. Kashtanova, Yana V. Polonskaya, Victor G. Chegodaev, Valentina I. Frolova, Izolda V. Bolshakova, Yulia V. Frolova, Yuri V. Ites
Summary: The study investigates the effects of different breeds of pig fat and vegetable oil on the growth, productivity, and lipid metabolism characteristics of quails. Quails fed with K-breed fat showed the most rapid growth, and the level of total cholesterol significantly decreased in all groups. Quails fed with P-breed fat had a higher risk of atherogenic index.
NATURAL PRODUCTS JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Evgeniia V. Garbuzova (Striukova), Victoriya S. Shramko, Elena V. Kashtanova, Yana V. Polonskaya, Ekaterina M. Stakhneva, Alexey V. Kurguzov, Ivan S. Murashov, Alexander M. Chernyavsky, Yuliya I. Ragino
Summary: The study aimed to investigate the levels of adipokines and their associations with unstable atherosclerotic plaques in patients with coronary atherosclerosis and abdominal obesity (AO). The findings showed that patients with AO and unstable plaques had higher levels of GLP-1 and lower levels of lipocalin-2. Lipocalin-2 was inversely associated with unstable plaques. The conclusion is that GLP-1 is directly associated with AO, while lipocalin-2 is inversely associated with unstable plaques in patients with AO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Evgeniia V. Garbuzova, Alyona D. Khudiakova, Lilia V. Shcherbakova, Elena V. Kashtanova, Yana V. Polonskaya, Ekaterina M. Stakhneva, Yulia I. Ragino
Summary: This study found that in young people with dyslipidemia, abdominal obesity and increased resistin and GIP levels are associated with the presence of renal dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Evgeniia V. Garbuzova, Lilia V. Shcherbakova, Oksana D. Rymar, Alyona D. Khudiakova, Victoria S. Shramko, Yulia I. Ragino
Summary: In young people, high triglyceride levels, obesity, and a low level of education are associated with the risk of developing type 2 diabetes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
A. V. Polonskaya, E. V. Kashtanova, E. M. Stakhneva, V. S. Shramko, E. V. Sadovski, S. R. Ledovskikh, L. V. Shcherbakova, E. V. Garbuzova, A. D. Khudyakova, Yu. Ragino, Ragino Yu.I
Summary: The study examined the levels of metabolic hormones in young people with arterial hypertension and abdominal obesity. It found that individuals with arterial hypertension had higher levels of amylin, C-peptide, and glucose, as well as lower levels of peptide YY. Other studied parameters did not show significant differences between the experimental and control groups. Abdominal obesity was associated with the levels of C-peptide, glucagon-like peptide-1, glucagon, and insulin in the experimental group, and with the levels of C-peptide, insulin, and glucose in the control group. The odds of arterial hypertension in individuals under 45 years old were associated with a decrease in the level of peptide YY, an increase in the level of amylin, and an increase in waist circumference.
BYULLETEN SIBIRSKOY MEDITSINY
(2023)
Article
Biochemistry & Molecular Biology
Sergey Semaev, Elena Shakhtshneider, Liliya Shcherbakova, Pavel Orlov, Dinara Ivanoshchuk, Sofia Malyutina, Valery Gafarov, Mikhail Voevoda, Yuliya Ragino
Summary: This study aimed to analyze the potential associations between several genetic factors and the risk of myocardial infarction (MI). The results showed that certain genotypes of rs1333049 and rs429358 and rs7412 were highly associated with MI, suggesting their inclusion in a genetic risk score.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Alena D. Khudiakova, Yana V. Polonskaya, Victoria S. Shramko, Lilia V. Shcherbakova, Evgeniia V. Garbuzova, Elena V. Kashtanova, Yulia I. Ragino
Summary: The research aimed to study the associations between adipocytokines and cardiovascular events risk and determine the threshold values of adipocytes for the prognosis of cardiovascular events in young individuals. The study found that measuring levels of amylin, PP, and TNFa in blood serum can be used to assess the risk of cardiovascular events in young people.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
