Fat Wasting Is Damaging: Role of Adipose Tissue in Cancer-Associated Cachexia

Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model

(2019) Qiqi Yang et al.   Disease Models & Mechanisms

CD8+ T cells induce cachexia during chronic viral infection

(2019) Hatoon Baazim et al.   NATURE IMMUNOLOGY

Macrophages protect against loss of adipose tissue during cancer cachexia

(2019) Merve Erdem et al.   Journal of Cachexia Sarcopenia and Muscle

Modeling Human Cancer-induced Cachexia

(2019) Erin E. Talbert et al.   Cell Reports

Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance

(2018) Hideki Iwamoto et al.   Cell Metabolism

The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting

(2018) Sawsan Elattar et al.   FASEB JOURNAL

Crotamine induces browning of adipose tissue and increases energy expenditure in mice

(2018) Marcelo P. Marinovic et al.   Scientific Reports

Mitochondrial dynamics in cancer-induced cachexia

(2018) Miranda van der Ende et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Adipose tissue browning in cancer-associated cachexia can be attenuated by inhibition of exosome generation

(2018) Wenjun Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inter-tissue communication in cancer cachexia

(2018) Josep M. Argilés et al.   Nature Reviews Endocrinology

TNF-α and cancer cachexia: Molecular insights and clinical implications

(2017) Hetal J. Patel et al.   LIFE SCIENCES

Alcohol intake aggravates adipose browning and muscle atrophy in cancer-associated cachexia

(2017) Bo Wang et al.   Oncotarget

Establishment and characterization of a novel murine model of pancreatic cancer cachexia

(2017) Katherine A. Michaelis et al.   Journal of Cachexia Sarcopenia and Muscle

A phase III randomized study comparing the effects of oxandrolone (Ox) and megestrol acetate (Meg) on lean body mass (LBM), weight (wt) and quality of life (QOL) in patients with solid tumors and weight loss receiving chemotherapy

(2017) G. J. Lesser et al.   JOURNAL OF CLINICAL ONCOLOGY

Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials

(2016) Jennifer S Temel et al.   LANCET ONCOLOGY

Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia

(2016) Tomoya Fukawa et al.   NATURE MEDICINE

Experimental cancer cachexia: Evolving strategies for getting closer to the human scenario

(2016) Fabio Penna et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

(2016) Andrea Bonetto et al.   Jove-Journal of Visualized Experiments

Detection of Pancreatic Cancer–Induced Cachexia Using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance

(2015) Paul T. Winnard et al.   CANCER RESEARCH

Myocardin-Related Transcription Factor A Regulates Conversion of Progenitors to Beige Adipocytes

(2015) Meghan E. McDonald et al.   CELL

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

Malignant Drosophila Tumors Interrupt Insulin Signaling to Induce Cachexia-like Wasting

(2015) Alejandra Figueroa-Clarevega et al.   DEVELOPMENTAL CELL

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

Cellular origins of cold-induced brown adipocytes in adult mice

(2015) Yun-Hee Lee et al.   FASEB JOURNAL

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

(2015) Surendra K. Shukla et al.   Oncotarget

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Ebf2 is a selective marker of brown and beige adipogenic precursor cells

(2014) Wenshan Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New cancer cachexia rat model generated by implantation of a peritoneal dissemination-derived human stomach cancer cell line

(2013) Kiyoshi Terawaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma–induced cachexia

(2013) Melissa J. Puppa et al.   FASEB JOURNAL

Simvastatin reduces wasting and improves cardiac function as well as outcome in experimental cancer cachexia

(2013) Sandra Palus et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

(2013) Tim J. Schulz et al.   NATURE

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Inhibitory Effects of Isoflavones on Tumor Growth and Cachexia in Newly Established Cachectic Mouse Models Carrying Human Stomach Cancers

(2013) Kazuyoshi Yanagihara et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Stem cells for skeletal muscle regeneration: therapeutic potential and roadblocks

(2013) Fabrizio Rinaldi et al.   Translational Research

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

(2012) Paul A. Dutchak et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia

(2012) K. T. Murphy et al.   Disease Models & Mechanisms

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Cancer cachexia is associated with a decrease in skeletal muscle mitochondrial oxidative capacities without alteration of ATP production efficiency

(2012) Cloé M. Julienne et al.   Journal of Cachexia Sarcopenia and Muscle

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

(2011) Tomas B. Waldén et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gut barrier dysfunction in the ApcMin/+ mouse model of colon cancer cachexia

(2011) Melissa J. Puppa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival

(2011) F. Robert et al.   CANCER RESEARCH

Cancer cachexia: A systematic literature review of items and domains associated with involuntary weight loss in cancer

(2011) David Blum et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Nutritional Interventions for Cancer-Induced Cachexia

(2011) Norleena P. Gullett et al.   CURRENT PROBLEMS IN CANCER

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Low Levels of Lipogenic Enzymes in Peritumoral Adipose Tissue of Colorectal Cancer Patients

(2011) Maria Notarnicola et al.   LIPIDS

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia

(2011) S. K. Das et al.   SCIENCE

Ursodeoxycholic acid treatment in a rat model of cancer cachexia

(2011) Anika Tschirner et al.   Journal of Cachexia Sarcopenia and Muscle

The cachexia score (CASCO): a new tool for staging cachectic cancer patients

(2011) Josep M. Argilés et al.   Journal of Cachexia Sarcopenia and Muscle

The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial

(2011) James T. Dalton et al.   Journal of Cachexia Sarcopenia and Muscle

Intramyocellular lipid droplets increase with progression of cachexia in cancer patients

(2011) Nathan A. Stephens et al.   Journal of Cachexia Sarcopenia and Muscle

Potentiation of ghrelin signaling attenuates cancer anorexia–cachexia and prolongs survival

(2011) N Fujitsuka et al.   Translational Psychiatry

Role of β1-adrenoceptor in increased lipolysis in cancer cachexia

(2010) Dong-xing Cao et al.   CANCER SCIENCE

Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells

(2010) Christoph Lepper et al.   GENESIS

Activity level, apoptosis, and development of cachexia in ApcMin/+ mice

(2010) Kristen A. Baltgalvis et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

Increased Bone Marrow Fat in Anorexia Nervosa

(2009) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A placebo-controlled, double-blind trial of infliximab for cancer-associated weight loss in elderly and/or poor performance non-small cell lung cancer patients (N01C9)

(2009) Aminah Jatoi et al.   LUNG CANCER

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Lipolysis-Not inflammation, cell death, or lipogenesis-Is involved in adipose tissue loss in cancer cachexia

(2008) Mikael Rydén et al.   CANCER

Rikkunshito, an Herbal Medicine, Suppresses Cisplatin-Induced Anorexia in Rats Via 5-HT2 Receptor Antagonism

(2008) Hiroshi Takeda et al.   GASTROENTEROLOGY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR