Journal
CARBOHYDRATE POLYMERS
Volume 148, Issue -, Pages 115-124Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.04.049
Keywords
Chitosan; Biocomposites; Bovine bone powder; Atopic dermatitis; Skin lesions
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Funding
- CAPES
- CNPq [441888/2014-3]
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Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects a large percent of the worldis population. This long-lasting skin disease has been treated by different approaches according to its causative agent and severity. Nonetheless, the use of advanced biomaterials to treat AD is poorly explored. The present study assessed the protective effectiveness of biocomposites films based on chitosan (Cs), poly(vinyl alcohol) (PVA) and bovine bone powder (BBP) on AD-like skin lesions. These original biocomposites were fully characterized and in vivo biological assays concerning the AD treatment were performed using a mouse model induced by 2,4-dinitrochlorobenzene (DNCB). The dorsal skin and ear of Balb/c female mice were challenging cutaneously with DNCB. Our findings demonstrate BBP-based biocomposite attenuated and treated considerably the DNCB-induced skin lesions in an AD-like model. In this sense, this study suggests that this original biocomposite may be applied as an active biomaterial for AD treatment. (C) 2016 Elsevier Ltd. All rights reserved.
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