Article
Gastroenterology & Hepatology
Eiko Yamada, Casey G. Martin, Nancy Moreno-Huizar, Jennifer Fouquier, C. Preston Neff, Sara L. Coleman, Jennifer M. Schneider, Jonathan Huber, Nichole M. Nusbacher, Martin McCarter, Thomas B. Campbell, Catherine A. Lozupone, Brent E. Palmer
Summary: Men who have sex with men (MSM), regardless of HIV infection status, have a distinct intestinal microbiome compared to men who have sex with women (MSW) and women. Elevated expression of CCR5, a critical co-receptor for HIV, in HIV-negative MSM is linked to the altered gut microbiome composition. Holdemanella biformis was found to be associated with increased frequency of CCR5(+) CD4(+) T cells in MSM. This study provides novel insights into the potential mechanism linking intestinal dysbiosis in MSM to HIV transmission and mucosal pathogenesis.
Review
Cell Biology
Sepiso K. Masenga, Bislom C. Mweene, Emmanuel Luwaya, Lweendo Muchaili, Makondo Chona, Annet Kirabo
Summary: The development of antiretroviral drugs (ARVs) is a significant achievement in managing HIV infections by suppressing viral activity and extending lifespan. However, the success of HIV in evading the immune system has hindered the discovery of an effective treatment for four decades. Understanding the molecular interaction between HIV and host cells is crucial for developing preventive and curative therapies. This review highlights the inherent mechanisms of HIV, such as targeting CD4(+) lymphocytes, downregulating MHC class I and II, antigenic variation, and minimizing antibody access, which collectively render the immune system ineffective.
Article
Immunology
Qiongyu Chen, Yan Zhao, Yonghong Zhang, Jianbo Zhang, Wenshu Lu, Chih-Hao Chang, Shisong Jiang
Summary: The human immunodeficiency virus (HIV) is a global pandemic with no cure identified yet. HIV-induced death of lymphocytes involves both necrosis and apoptosis. A pro-apoptotic TNF peptide (P13) inhibits HIV-related cell death and viral transmission, while a pro-necrotic TNF peptide (P16) has little effect. Understanding cell death mechanisms may provide drug targets to reduce CD4(+) cell loss and viral reservoir formation in HIV infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Ju-Shuang Li, Yu-Zhou Gu, Feng-Su Hou, Yong-Heng Lu, Xiao-Ru Fan, Jia-Ling Qiu, Qing-Ling Yang, Jing Gu, Jing-Hua Li, Dong Roman Xu, Chun Hao
Summary: This study explores the effectiveness and associated factors of a recruitment strategy using WeChat-based HIV e-report exchange in social networks among MSM. The results show that using e-report for recruitment is feasible, and the success of online recruitment depends on the familiarity of MSM with the digital tool.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Hematology
Marie Tamagne, Sadaf Pakdaman, Pablo Bartolucci, Anoosha Habibi, Frederic Galacteros, France Pirenne, Benoit Vingert
Summary: The study found that high levels of CXCR5(+)PD1(+)CD4(+) T cells in whole blood may be a characteristic of nonalloimmunized patients; however, these cells did not display the phenotypic characteristics of active Tfh cells. Instead, a decrease in blood quiescent Tfh-cell levels was observed in nonalloimmunized polytransfused patients.
Article
Immunology
Zehua Zhou, Ping Ma, Yi Feng, Weidong Ou, Min Wei, Yiming Shao
Summary: Chinese MSM play a crucial role in HIV-1 transmission to their family members, calling for more effective preventive measures to be implemented.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Multidisciplinary Sciences
Rodrigo R. R. Duarte, Oliver Pain, Robert L. Furler, Douglas F. Nixon, Timothy R. Powell
Summary: This study revealed the host genetic factors associated with protection against HIV-1, identifying 25 genetic loci and 15 susceptibility genes related to HIV-1 acquisition. Further functional studies and larger genetic research have the potential to enhance understanding of the host mechanisms related to protection against HIV-1.
Article
Environmental Sciences
Bugao Guan, Hongbo Li, Jian Yao, Jinbao Guo, Fei Yu, Guangrun Li, Benhai Wan, Jun Ma, Desong Huang, Lu Sun, Yan Chen
Summary: The study finds that CCL3 can be derived from TAMs and tumor cells of colon adenocarcinoma (COAD), and it promotes the migration and invasiveness of COAD cells by activating the Akt signaling pathway through binding to CCR5. High expression of CCL3/CCR5 is closely associated with poor prognosis of COAD patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Immunology
Jessy J. Duran Ramirez, Tala Ballouz, Huyen Nguyen, Katharina Kusejko, Sandra E. Chaudron, Michael Huber, Hans H. Hirsch, Matthieu Perreau, Alban Ramette, Sabine Yerly, Matthias Cavassini, Marcel Stockle, Hansjakob Furrer, Pietro Vernazza, Enos Bernasconi, Huldrych F. Gunthard, Roger D. Kouyos
Summary: The study reveals a significant increase in non-B subtypes of HIV-1 among men who have sex with men (MSM) in Switzerland, with CRF01_AE being the most prevalent subtype. The majority of molecular transmission clusters (MTCs) among MSM were found to be comprised of Europeans.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Abigail J. S. Armstrong, Kevin Quinn, Jennifer Fouquier, Sam X. Li, Jennifer M. Schneider, Nichole M. Nusbacher, Katrina A. Doenges, Suzanne Fiorillo, Tyson J. Marden, Janine Higgins, Nichole Reisdorph, Thomas B. Campbell, Brent E. Palmer, Catherine A. Lozupone
Summary: The study revealed that factors such as gut microbiome, immune phenotype, and diet contribute to metabolic health in people living with HIV. Elevated plasma lipopolysaccharide-binding protein (LBP) was identified as a key predictor of impaired metabolic health. This highlights the role of inflammatory processes and gut microbiome interaction in metabolic disease among HIV-positive and negative individuals.
Article
Public, Environmental & Occupational Health
Shi Zou, Yuting Tan, Yanni Xiang, Yang Liu, Qi Zhu, Songjie Wu, Wei Guo, Mingqi Luo, Ling Shen, Ke Liang
Summary: This study found a significant increase in CD4 and CD8 double-positive (DP) T cells in patients with HIV/TB coinfection. Additionally, these DP T cells also expressed more cytotoxic markers. This suggests that DP T cells may play an important immune role in HIV/TB infection.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Microbiology
Yue Chen, Huang Lin, Mariah Cole, Alison Morris, Jeremy Martinson, Heather Mckay, Matthew Mimiaga, Joseph Margolick, Adam Fitch, Barbara Methe, Vatsala Rangachar Srinivas, Shyamal Peddada, Charles R. Rinaldo
Summary: The study suggests that changes in gut microbiome in MSM prior to HIV-1 infection in the early phase of the AIDS pandemic may be associated with increased inflammatory biomarkers in the blood and risk for developing AIDS.
Article
Immunology
Matthew J. Gartner, Carolin Tumpach, Ashanti Dantanarayana, Jared Stern, Jennifer M. Zerbato, J. Judy Chang, Thomas A. Angelovich, Jenny L. Anderson, Jori Symons, Steve G. Deeks, Jacqueline K. Flynn, Sharon R. Lewin, Melissa J. Churchill, Paul R. Gorry, Michael Roche
Summary: Based on longitudinal env sampling, this study found that HIV can persist in different CD4(+) T-cell subsets despite suppressive ART. The clonal expansion of infected cells was observed over time. The research also revealed that coreceptor usage can influence the sensitivity of broadly neutralizing antibodies.
Article
Infectious Diseases
Yun Lan, Xizi Deng, Linghua Li, Weiping Cai, Junbin Li, Xiaoli Cai, Feng Li, Fengyu Hu, Chunliang Lei, Xiaoping Tang
Summary: The study in Guangdong province found that drug resistance mutations were more common in NNRTIs among MSM with ART failure. The transmission network analysis revealed a complex transmission pattern, with younger HIV-1-infected MSM with multiple links requiring more attention.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Multidisciplinary Sciences
Nienke H. van Teijlingen, Julia Eder, Ramin Sarrami-Forooshani, Esther M. Zijlstra-Willems, Jan-Paul W. R. Roovers, Elisabeth van Leeuwen, Carla M. S. Ribeiro, Teunis B. H. Geijtenbeek
Summary: This study assessed the impact of immune activation on the susceptibility of primary human vaginal Langerhans cells (LCs) to HIV-1. It was found that bacterial TLR ligand activation increased HIV-1 infection in immature vaginal LCs, while viral TLR ligands were unable to induce HIV-1 replication. This study highlights the role of vaginal LCs in protecting against mucosal HIV-1 infection and suggests that bacterial STIs can increase the risk of HIV-1 acquisition in women.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
S. X. Li, A. J. S. Armstrong, C. P. Neff, M. Shaffer, C. A. Lozupone, B. E. Palmer
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2016)
Article
Plant Sciences
Sara L. Coleman, Roger D. Hurst, Gregory M. Sawyer, Marlena C. Kruger
JOURNAL OF BERRY RESEARCH
(2016)
Review
Medical Laboratory Technology
Michael Shaffer, Abigail J. S. Armstrong, Vanessa V. Phelan, Nichole Reisdorph, Catherine A. Lozupone
TRANSLATIONAL RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Sara L. Coleman, Odette M. Shaw
Article
Medicine, General & Internal
Charles Preston Neff, Owen Krueger, Kathy Xiong, Sabrina Arif, Nichole Nusbacher, Jennifer M. Schneider, Annie W. Cunningham, Abigail Armstrong, Sam Li, Martin D. McCarter, Thomas B. Campbell, Catherine A. Lozupone, Brent E. Palmer
Article
Nutrition & Dietetics
Sara L. Coleman, Young-Ki Park, Ji-Young Lee
EUROPEAN JOURNAL OF NUTRITION
(2011)
Article
Biochemistry & Molecular Biology
Chai Siah Ku, Youngki Park, Sara L. Coleman, Jiyoung Lee
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2012)
Article
Microbiology
Abigail J. S. Armstrong, Michael Shaffer, Nichole M. Nusbacher, Christine Griesmer, Suzanne Fiorillo, Jennifer M. Schneider, C. Preston Neff, Sam X. Li, Andrew P. Fontenot, Thomas Campbell, Brent E. Palmer, Catherine A. Lozupone
Article
Microbiology
Sam X. Li, Sharon Sen, Jennifer M. Schneider, Ka-Na Xiong, Nichole M. Nusbacher, Nancy Moreno-Huizar, Michael Shaffer, Abigail J. S. Armstrong, Erin Severs, Kristine Kuhn, Charles P. Neff, Martin McCarter, Thomas Campbells, Catherine A. Lozupone, Brent E. Palmer
Article
Microbiology
Abigail J. S. Armstrong, Kevin Quinn, Jennifer Fouquier, Sam X. Li, Jennifer M. Schneider, Nichole M. Nusbacher, Katrina A. Doenges, Suzanne Fiorillo, Tyson J. Marden, Janine Higgins, Nichole Reisdorph, Thomas B. Campbell, Brent E. Palmer, Catherine A. Lozupone
Summary: The study revealed that factors such as gut microbiome, immune phenotype, and diet contribute to metabolic health in people living with HIV. Elevated plasma lipopolysaccharide-binding protein (LBP) was identified as a key predictor of impaired metabolic health. This highlights the role of inflammatory processes and gut microbiome interaction in metabolic disease among HIV-positive and negative individuals.
Article
Biotechnology & Applied Microbiology
Abigail J. S. Armstrong, Veenat Parmar, Martin J. Blaser
Summary: The oral microbiome is connected with lung health and may play a role in the progression of SARS-CoV-2 infection. Saliva-based tests for SARS-CoV-2 can be used to assess the oral microbiome, but collection kits have not been tested for accuracy. Collecting saliva with a preservative and depleting human DNA before sequencing can lead to more consistent measures of the oral microbiome and increased abundance of bacterial sequences. Additionally, the study found that the distance of microbiome composition was smaller within subjects over time compared to between unrelated subjects.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Biochemistry & Molecular Biology
Sara L. Coleman, Marlena C. Kruger, Gregory M. Sawyer, Roger D. Hurst
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)