Journal
CARBOHYDRATE POLYMERS
Volume 137, Issue -, Pages 214-221Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.10.026
Keywords
Carrageenan hydrogel; Polythiophene; Acetylsalicylic acid; Diffusion coefficient; Electrically controlled release
Categories
Funding
- Conductive and Electroactive Polymers Research Unit of Chulalongkorn University
- Thailand Research Fund (TRF)
- Royal Thai Government
Ask authors/readers for more resources
Blends between polythiophene (PTh) and a carrageenan hydrogel were fabricated as the matrix for the electric field assisted drug release. The pristine carrageenan and the blend films were prepared by the solution casting using acetylsalicylic acid (ASA) as the anionic model drug and Mg2+, Ca2+, and Ba2+ as the crosslinking agents. The ASA was released by the Fickian diffusion mechanism. The diffusion coefficient decreased with increasing crosslinking ratio or decreasing crosslinking ionic radii. The diffusion coefficients were greater with the applied electrical potentials by an order of magnitude relative to those without electric field. Moreover, the diffusion coefficients with PTh as the drug carrier were higher than those without PTh. Thus, the presence of the conductive polymer in the hydrogel blend coupled with applied electric field is shown here to drastically enhance the drug delivery rate. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available