Journal
CARBOHYDRATE POLYMERS
Volume 151, Issue -, Pages 313-320Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.05.074
Keywords
Chitosan; Scaffolds; Hydroxylated boron nitride nanotubes; Mechanical strength; Cell adhesion
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Funding
- Scientific and Technological Research Council of Turkey (TUBITAK) [112M480]
- Yeditepe University
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With their low toxicity, high mechanical strength and chemical stability, boron nitride nanotubes (BNNTs) are good candidates to enhance the properties of polymers, composites and scaffolds. Chitosan-based scaffolds are exhaustively investigated in tissue engineering because of their biocompatibility and antimicrobial activity. However, their spontaneous degradation prevents their use in a range of tissue engineering applications. In this study, hydroxylated BNNTs (BNNT-OH) were included into a chitosan scaffold and tested for their mechanical strength, swelling behavior and biodegradability. The results show that inclusion of BNNTs-OH into the chitosan scaffold increases the mechanical strength and pore size at values optimal for high cellular proliferation and adhesion. The chitosan/BNNT-OH scaffold was also found to be non-toxic to Human Dermal Fibroblast (HDF) cells due to its slow degradation rate. HDF cell proliferation and adhesion were increased as compared to the chitosan-only scaffold as observed by scanning electron microscopy (SEM) and fluorescent microscopy images. (C) 2016 Elsevier Ltd. All rights reserved.
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