Journal
CARBOHYDRATE POLYMERS
Volume 151, Issue -, Pages 511-522Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2016.05.098
Keywords
Marine angiosperm; Sulfated polysaccharide; LC-ESI-MS/MS analysis; NMR spectroscopy; Antihypertensive properties
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A sulfated polysaccharide was successfully isolated from Cymodocea nodosa (CNSP). This is the first report that indicates the chemical composition, structural characterization, functional and antihypertensive properties of this polysaccharide. The CNSP consisted mainly of sulfate (23.17%), total sugars (54.90%), galactose (44.89%), mannose (17.30%), arabinose (12.05%), xylose (9.18%), maltose (1.07%) and uronic acid (11.03%) with low water activity (0.49). CNSP had an XRD pattern that was typical for a semi-crystalline polymer with homogeneous structure. It also displayed an important anti -hypertensive activity (IC50 = 0.43 mg ml) with a dose-dependent manner using a synthetic substrate, N-hippuryl-His-Leu hydrate salt (HHL). Overall, the results indicate that CNSP have attractive chemical, functional and biological properties, with a preliminary structural may have a backbone of branched 6-O-sulfated (1 -> 4) galactosidic linkages, which can be considered in the future as alternative additive in various foods, cosmetic and pharmaceutical preparations. (C) 2016 Elsevier Ltd. All rights reserved.
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