Article
Biochemistry & Molecular Biology
Yushi Abe, Daigo Ochiai, Masako Taguchi, Seiji Kanzaki, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: Human amniotic fluid stem cells (hAFSCs) can form aggregates with host immune cells and alleviate inflammation. Additionally, hAFSCs can increase regulatory T cells in the acquired immune system. Therefore, hAFSCs play an important role in the treatment of inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Han Luo, Zhen Wang, Fang Qi, Dali Wang
Summary: Complete wound regeneration is crucial for maintaining skin structure and physiological functions, and amniotic fluid stem cells (AFSCs) have the potential to play a significant role in wound generation and treatment. AFSCs are easily accessible and have advantages such as anti-inflammatory and immunomodulatory properties, which can promote full wound regeneration.
CHINESE MEDICAL JOURNAL
(2022)
Article
Cell Biology
Yushi Abe, Daigo Ochiai, Seiji Kanzaki, Yu Sato, Toshimitsu Otani, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: This study demonstrates that hAFSCs are effective in the treatment and prevention of inflammation-induced preterm birth. hAFSCs suppress inflammation and reduce preterm birth by switching macrophage polarity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Ying-Cheng Chen, Ying-Wei Lan, Shiaw-Min Huang, Chih-Ching Yen, Wei Chen, Wan-Ju Wu, Theresa Staniczek, Kowit-Yu Chong, Chuan-Mu Chen
Summary: The study demonstrates that hAFMSCs can inhibit the proliferation, tumor growth, and invasion of PDAC cells by altering cell cycle and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Rodrigo N. Riedel, Antonio Perez-Perez, Victor Sanchez-Margalet, Cecilia L. Varone, Julieta L. Maymo
Summary: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant social, economic, and health challenges globally. Stem cells, particularly human amniotic membrane cells, have shown promising potential as a therapeutic approach for COVID-19 due to their immunoregulatory and anti-inflammatory properties.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Francesca Casciaro, Silvia Zia, Mattia Forcato, Manuela Zavatti, Francesca Beretti, Emma Bertucci, Andrea Zattoni, Pierluigi Reschiglian, Francesco Alviano, Laura Bonsi, Matilde Yung Follo, Marco Demaria, Barbara Roda, Tullia Maraldi
Summary: This study utilized Celector® technology to classify and characterize hAFSCs, uncovering deep intra-population differences and validating their impact on stemness properties. The results suggest the importance of selecting cellular fractions with the highest potential for use in regenerative medicine.
Article
Cell & Tissue Engineering
Jiayue Huang, Wenwen Zhang, Jie Yu, Yating Gou, Nizhou Liu, Tingting Wang, Congcong Sun, Benyuan Wu, Changjiang Li, Xinpei Chen, Yanhua Mao, Yingfeng Zhang, Jia Wang
Summary: This study investigated the therapeutic effect of hAMSCs combined with PPCNg transplantation on promoting the regeneration of injured endometrium. The results showed that hAMSCs maintained normal cell proliferation, apoptosis and cell cycle in PPCNg. In addition, hAMSCs combined with PPCNg intrauterine transplantation facilitated the regeneration of injured endometrium and restored reproductive capacity.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Maryam Lale Ataei, Mohammad Karimipour, Parviz Shahabi, Roghiyeh Pashaei-Asl, Esmaeil Ebrahimie, Maryam Pashaiasl
Summary: In the study of spinal cord injury, the use of MSCs and CM from human amniotic fluid can promote neuroblast regeneration and repair of damaged neural tissue, while reducing the number of astrocytes. MSCs have a higher potential for restoration compared to CM.
Review
Cell Biology
Aisha Naeem, Nikita Gupta, Usra Naeem, Muhammad Jawad Khan, Mohamed A. Elrayess, Wanxing Cui, Chris Albanese
Summary: The successful translation of MSCs from bench to bedside relies on their regenerative capabilities and immunomodulatory potential. Adult tissue-derived MSCs face challenges in sourcing and characterization, while alternative sources, such as amniotic membrane, offer advantages for clinical applications with optimized culture methods.
Article
Cell Biology
Yuli Hu, Yang V. Li
Summary: Environmental changes can induce stress-induced cellular reprogramming, as evidenced by the expression of pluripotent stem cell markers following brief strong acid treatment. This phenomenon resulted in faster cell growth and shorter doubling time, along with sensitivity to metal ion chelation. The findings suggest that somatic cells have the potential to express pluripotent markers under stressful conditions, providing new insights into cellular survival mechanisms.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Cell & Tissue Engineering
Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali, Hassan Niknejad
Summary: Human amniotic fluid/membrane mesenchymal stem cells have conflicting roles in cancer treatment, with some studies demonstrating their anticancer effects while others suggesting their potential to promote cancer progression.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Giedre Valiuliene, Aiste Zentelyte, Elizabet Berzanskyte, Ruta Navakauskiene
Summary: hAFSCs derived from pathological gestations with polyhydramnios exhibit differences in metabolic and inflammatory status compared to hAFSCs from normal gestations, as well as possessing lower neurogenic potential. Further studies are necessary to explore the potential of hAFSCs from polyhydramnios in stem cell-based therapies and strategies to enhance their characteristics for regenerative medicine purposes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Anatomy & Morphology
Milad Hasanpour, Reza Rahbarghazi, Alireza Nourazarian, Fatemeh Khaki-Khatibi, Cigir Biray Avci, Mehdi Hassanpour, Mehdi Talebi, Hossein Taghavi, Leila Salimi
Summary: This study investigated the paracrine effect of amniotic fluid-derived mesenchymal stem cells on Alzheimer's disease changes. The results showed that the secretion of amniotic fluid stem cells can reduce AD-like pathologies and improve cell viability.
Article
Biotechnology & Applied Microbiology
Aiste Zentelyte, Deimante Zukauskaite, Ieva Jaceryte, Veronika V. Borutinskaite, Ruta Navakauskiene
Summary: In this study, short-term treatments of small molecules were used to enhance the properties and differentiation capability of human amniotic fluid stem cells (AFSC). The combinations of epigenetically active compounds and multifunctional molecules upregulated genes involved in pluripotency, leading to a more energetically active phenotype in AFSCs. The small molecule treatments also showed a beneficial effect on differentiation potential towards a neurogenic lineage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naiyou Liu, Charles M. Bowen, Mohammadali M. Shoja, Karen Larissa Castro de Pereira, Laxmi Priya Dongur, Antonio Saad, William K. Russell, Thomas Christopher Broderick, Jeffrey H. Fair, William Samuel Fagg
Summary: Myofibroblast activation is a cellular response to physiological or pathological insults. In this study, co-cultured amniotic cell conditioned media (coACCM) was found to activate myofibroblast, while amniotic fluid (AF) represses it. These findings suggest that different biologics can elicit different cellular responses and may have broad utility in the clinic and the lab.