Article
Endocrinology & Metabolism
Jackie Elliott, Gordon Sloan, Lynda Stevens, Dinesh Selvarajah, Giorgio Cruccu, Rajiv A. Gandhi, Peter Kempler, John H. Fuller, Nishi Chaturvedi, Solomon Tesfaye
Summary: This study analyzed the EURODIAB Prospective Complications Study data to investigate the incidence and risk factors of painful DPN. It found that female sex was a risk factor for painful DPN and there was less evidence of diabetic nephropathy in painful DPN cases.
Article
Pharmacology & Pharmacy
Qingqing Yuan, Xiang Zhang, Wandi Wei, Jialing Zhao, Yuhao Wu, Song Zhao, Lin Zhu, Peiran Wang, Jun Hao
Summary: In this study, lycorine was identified as a potential drug for diabetic peripheral neuropathy. It was found that lycorine promoted autophagy in Schwann cells through AMPK pathway activation and MMP9 downregulation.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Chenxi Li, Weimin Wang, Qiuhe Ji, Xingwu Ran, Hongyu Kuang, Xuefeng Yu, Hui Fang, Jing Yang, Jing Liu, Yaoming Xue, Bo Feng, Minxiang Lei, Dalong Zhu
Summary: This study aimed to investigate the prevalence and risk factors of painful diabetic peripheral neuropathy (PDPN) in mainland China among patients with type 2 diabetes mellitus (T2DM) and diabetic peripheral neuropathy (DPN). A nationwide cross-sectional study was conducted, involving T2DM patients with DPN from 25 provinces in China. The study found that over half of the patients with DPN in mainland China had PDPN. Various factors such as age, education level, duration of diabetes, cholesterol levels, and comorbidities were independently associated with PDPN.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Jia-Lin Yuan, Le Sun, Bao-Lin Su, Chuang-Xiong Hong
Summary: This case presents a specific adverse drug reaction of corticosteroids that causes diabetes mellitus and subsequently leads to peripheral neuropathy in an acute onset. Mecobalamin and Acupuncture were employed and steroids were discontinued, 8 months later he recovered part of his strength and sensation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Domenico Beccia, Chiara Brin, Maria Alfano, Jessica Di Salvo, Raffaella Epifani, Alessia Piacevole, Giuseppina Tagliaferri, Maria Rocco, Ilaria Iadicicco, Giovanni Docimo, Luca Rinaldi, Celestino Sardu, Teresa Salvatore, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes mellitus. It can manifest as sensory-motor symptoms in the peripheral nervous system and as multiorgan neurovegetative symptoms due to impairment in sympathetic/parasympathetic conduction. The exact pathophysiology and progression of diabetic neuropathy are not fully understood. This review aims to provide insights into the recent discoveries in the pathophysiological and diagnostic aspects of this complex complication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Tatiane Vilaca, Margaret Paggiosi, Jennifer S. Walsh, Dinesh Selvarajah, Richard Eastell
Summary: The study found that fracture risk is increased in type 1 diabetes patients, and diabetic neuropathy may contribute to this. Patients with neuropathy had poorer performance in bone structure and physical tests compared to the control group.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Rehabilitation
Martin Vargas Matamala, Claudio Tapia, Francisco Salvador Saguez, Juan Guerrero-Henriquez
Summary: This study aimed to investigate the impact of sensory perturbations on static postural control in older individuals with type 2 diabetes mellitus. The results showed that participants with diabetes, with or without neuropathy, exhibited altered postural performance under sensory perturbations compared to those without diabetes. Additionally, participants with neuropathy showed impaired postural performance when one sensory system was disturbed. Overall, the Wii Balance Board can be a cost-effective tool for assessing balance impairment in individuals with diabetic neuropathy and can contribute to early interventions in diabetes care.
DISABILITY AND REHABILITATION
(2023)
Article
Pharmacology & Pharmacy
Noo Ree Cho, Yeuni Yu, Chang-Kyu Oh, Dai Sik Ko, Kyungjae Myung, Yoonsung Lee, Hee Sam Na, Yun Hak Kim
Summary: This study identified NPY and SLPI as potential biomarkers for diagnosing DPN in T2DM patients, with NPY potentially playing a protective role in the peripheral nervous system. Baseline characteristics did not differ between T2DM patients with and without DPN, except for a difference in sex ratio. Serum NPY levels were higher in T2DM patients with DPN compared to those without, while SLPI levels showed no significant difference.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Integrative & Complementary Medicine
Ahmed Essmat, Mohammed Salah Hussein
Summary: The study showed that green tea extract (GTE) may have a beneficial effect on certain neurophysiological parameters in patients with diabetic peripheral neuropathy (DPN), especially with more significant improvements observed at 8 and 16 weeks of treatment.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Yue Yin, Lina Wang, Ling Zhao, Lin Lin, Xueyong Shen
Summary: 10.6 μm laser moxibustion can relieve pain, improve microcirculation, and alleviate inflammation in DPN rats, possibly via the NF-κB inflammatory pathway.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jiangli Ban, Xiaoyu Pan, Liqun Yang, Zhuoya Ji, Ruoxi Zhen, Xueqing Zhang, Shuchun Chen
Summary: This study found a correlation between fibrinogen/albumin (FAR) index and diabetic peripheral neuropathy (DPN), with higher FAR levels associated with a higher prevalence of DPN. Furthermore, FAR had a negative correlation with nerve conduction velocities (NCV). Therefore, monitoring FAR levels in patients with diabetes is important for identifying those at higher risk for developing DPN, and managing FAR may be beneficial in preventing and delaying the onset of DPN.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Anna Vagvolgyi, Agnes Maroti, Monika Szocs, Csongor Poczik, Dora Urban-Pap, Istvan Baczko, Attila Nemes, Eva Csajbok, Krisztian Sepp, Peter Kempler, Andrea Orosz, Tamas Varkonyi, Csaba Lengyel
Summary: The study found early signs of peripheral sensory neurological impairments in young T1DM patients at the time of transition to adult diabetes care, providing valuable feedback for future follow-up care.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yifan Cheng, Wen Cao, Junzhe Zhang, Jiabin Wang, Xiang Liu, Qianqian Wu, Qingxia Lin
Summary: This study investigated the epidemiological characteristics and predictors of diabetic peripheral neuropathy (DPN) in adult patients with type 2 diabetes mellitus (DM). The results showed that age, history of hypertension, neutrophil and lymphocyte levels, HbA1c, and FT3 were significant predictors for the prevalence of DPN.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Multidisciplinary Sciences
Muhammad Akbar, Alvian Wandy, Gita Vita Soraya, Yudy Goysal, Mimi Lotisna, Muhammad Iqbal Basri
Summary: Long term consequences of diabetes mellitus (DM) may include multi-organ complications such as retinopathy, cardiovascular disease, neuronal, and kidney damage. One of the most prevalent and disabling complications of DM is diabetic peripheral neuropathy (DPN), which affects half of all diabetics. Early detection of small fiber neuropathy (SFN), a precursor to DPN, is crucial as it can help prevent cardiovascular events. Current testing modalities for SFN, such as punch skin biopsy, are invasive and impractical, leading to the need for alternative methods.
Article
Pharmacology & Pharmacy
L. -X. Xu, J. -H. Yin, D. Liang, P. Li, M. -G. Xu, G-L. Shi, Y. Wang, J. Yang
Summary: This study found a positive correlation between serum asprosin and diabetic peripheral neuropathy (DPN), and it identified asprosin as an influencing factor for DPN in community patients with type 2 diabetes mellitus (T2DM). The risk of DPN increased with higher levels of asprosin.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)