Review
Cell Biology
Baokang Wu, Yizhou Zhang, Yang Yu, Chongli Zhong, Qi Lang, Zhiyun Liang, Chao Lv, Feng Xu, Yu Tian
Summary: The long noncoding RNA H19 plays crucial roles in cancer by regulating multiple oncogenic signaling pathways that are involved in cell proliferation, migration, invasion, angiogenesis, and apoptosis. This suggests that H19 may be a novel therapeutic target for cancer treatment by modulating oncogenic signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Zhiyu Huang, Maoqing Zhang, Jiayue Li, Chenghua Lou
Summary: MAFG-AS1 is a long non-coding RNA that plays an important role in cancer progression. It has been shown to regulate various microRNAs and cell signaling pathways, leading to effects such as proliferation, metastasis, and epithelial-mesenchymal transition. Abnormal overexpression of MAFG-AS1 is associated with histological grade, TNM stage, invasion depth, poor overall survival, and lymph node metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pathology
Kamilya Jamel Baljon, Pushpamala Ramaiah, Ebraheem Abdu Musad Saleh, F. Al-dolaimy, Farqad Hassan Al-Dami, Kumaraswamy Gandla, Adnan Taan Alkhafaji, Ahmed hussien R. Abbas, Ali Hashiem Alsaalamy, Yashwant Singh Bisht
Summary: A significant number of women are diagnosed with breast cancer each year, making it one of the most common malignancies and leading causes of death globally. LncRNAs, including PVT1, have been identified as biomarkers and potential therapeutic targets for breast cancer due to their role in promoting cancer cell growth, metastasis, and invasion. This article explores the targeting of PVT1 as a treatment strategy for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Ruiming Li, Xia Wang, Chunming Zhu, Kefeng Wang
Summary: Long noncoding RNA PVT1 plays a crucial role in cancer development, being involved in tumor onset, proliferation, invasion, epithelial-mesenchymal transition, apoptosis, as well as influencing prognosis and resistance to radiotherapy and chemotherapy.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Article
Oncology
Agnes Luise Sorteberg, Vesa Halipi, Malin Wickstroem, Shahrzad Shirazi Fard
Summary: This study reveals that the sensitivity of neuroblastoma cells to cisplatin is determined by the phosphorylation of the cyclin-dependent kinase inhibitor p21(Cip1/Waf1). Neuroblastoma cells with high expression of phosphorylated p21(Cip1/Waf1) show resistance to cisplatin, while they are highly sensitive to the p21(Cip1/Waf1) inhibitor UC2288. Combination treatment of UC2288 with cisplatin significantly reduces cell viability and delays regrowth in resistant neuroblastoma cell lines.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Medicinal
Chengyu Hu
Summary: This review discusses the molecular mechanisms and clinical significance of the oncogene DSCAM-AS1 in various tumor types. Overexpression of DSCAM-AS1 is associated with cancer progression and invasion, making it a potential therapeutic target or tumor biomarker.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Diangeng Li, Liangyou Tang, Bo Liu, Shibo Xu, Meiling Jin, Wu Bo
Summary: The study revealed that RIPK2 is upregulated in KIRC tumor samples and is associated with adverse clinical features, metastasis, and immune signaling pathway dysregulations. Inhibition of RIPK2 activity significantly reduces kidney cancer cell viability and migration in vitro, as well as impairs tumor growth in vivo.
Article
Multidisciplinary Sciences
Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, Marta Sanchez-Soto, Jeongkyung Lee, Xiangning Xue, Ryan W. Logan, J. Robert Lane, Vijay K. Yechoor, Peter J. McCormick, Jens Meiler, R. Benjamin Free, David R. Sibley, Rita Bottino, Zachary Freyberg
Summary: Bromocriptine, an approved diabetes therapy, acts on brain dopamine D2 receptors and pancreas to regulate insulin and glucagon secretion, providing a new therapeutic mechanism for improving dysglycemia.
Article
Oncology
Wei Dai, Suqing Xie, Changyan Chen, Byeong Hyeok Choi
Summary: Ras proteins play important roles in cell processes through posttranslational modifications, such as sumoylation, which can affect cell signaling, migration, and tumorigenesis. Inhibiting the sumoylation process can potentially suppress tumor development by blocking key cellular pathways.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vittoria Infantino, Anna Santarsiero, Paolo Convertini, Simona Todisco, Vito Iacobazzi
Summary: In cancer cells, metabolic reprogramming under low-oxygen conditions is crucial for tumor survival, with HIF-1 playing a pivotal role. Mitochondria are key players in regulating cellular energy and closely interact with HIF-1 to drive metabolic and functional changes in cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Michael Latour, Nam-Gu Her, Santosh Kesari, Elmar Nurmemmedov
Summary: The WNT signaling pathway plays a crucial role in glioblastoma genesis and therapy resistance, presenting a therapeutic challenge. Current targeted therapies under clinical investigation may offer new treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K. C. Ng, Chengzhi Zhou, Ka Fai To, Yangchao Chen
Summary: The study identifies GRIN2D as a potential therapeutic target for pancreatic ductal adenocarcinoma (PDAC) and demonstrates its oncogenic role in PDAC progression.
BIOMARKER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sara Al Hussein Al Awamlh, Lauren K. Wareham, Michael L. Risner, David J. Calkins
Summary: Glaucoma, a multifactorial disease managed by lowering intraocular pressure, often leads to vision loss. The degeneration of retinal ganglion cells in glaucoma is similar to neurodegeneration in age-related CNS disorders, highlighting the potential of targeting insulin signaling for neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Duygu Kuzuoglu-Ozturk, Ozlem Aksoy, Christin Schmidt, Robin Lea, Jon D. Larson, Ryan R. L. Phelps, Nicole Nasholm, Megan Holt, Adrian Contreras, Miller Huang, Shannon Wong-Michalak, Hao Shao, Robert Wechsler-Reya, Joanna J. Phillips, Jason E. Gestwicki, Davide Ruggero, William A. Weiss
Summary: Deregulation of N-myc is a major cause of malignant brain tumors in children. This study characterizes the translatome of medulloblastoma and reveals that N-myc drives selective translation of transcripts promoting protein homeostasis. These findings identify a hidden molecular program promoting medulloblastoma formation and suggest potential new therapies for clinical use.
Article
Microbiology
Gargi Pal, Sheela Srivastava
ARCHIVES OF MICROBIOLOGY
(2015)
Article
Biotechnology & Applied Microbiology
Gargi Pal, Sheela Srivastava
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2015)
Article
Genetics & Heredity
Gargi Pal, Jeannette Huaman, Fayola Levine, Akintunde Orunmuyi, E. Oluwabunmi Olapade-Olaopa, Onayemi T. Onagoruwa, Olorunseun O. Ogunwobi
Article
Multidisciplinary Sciences
Gargi Pal, Olorunseun O. Ogunwobi
Article
Genetics & Heredity
Gargi Pal, Lia Di, Akintunde Orunmuyi, E. Oluwabunmi Olapade-Olaopa, Weigang Qiu, Olorunseun O. Ogunwobi
G3-GENES GENOMES GENETICS
(2020)
Article
Oncology
E. O. Asante-Asamani, Gargi Pal, Leslie Liu, Olorunseun O. Ogunwobi
Summary: Prostate cancer is the most commonly diagnosed solid organ cancer in men globally, and current diagnosis methods have limitations. The creation of a new composite score, Prostac, based on recently discovered PCa biomarkers, shows promise for improving PCa diagnosis accuracy.
FRONTIERS IN ONCOLOGY
(2021)
Meeting Abstract
Oncology
Fayola Levine, Emmanuel Asante-Asamani, Gargi Pal, Michael Liss, Olorunseun Ogunwobi
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Lin Zhu, Gargi Pal, Taylor Kazaoka, Rubia Shahbaz, Marsha Zibalese-Crawford, Sarah-Jane Dodd, Carolyn Y. Fang, Yin Tan, Grace X. Ma, Olorunseun O. Ogunwobi
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Meeting Abstract
Oncology
Gargi Pal, Emmanuel Asante-Asamani, Leslie Liu, Olorunseun O. Ogunwobi
Meeting Abstract
Oncology
Gargi Pal, Olorunseun Ogunwobi
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Meeting Abstract
Oncology
Gargi Pal, Lia Di, Akintunde Orunmuyi, E. Oluwabunmi Olapade-Olaopa, Weigang Qiu, Olorunseun O. Ogunwobi
Meeting Abstract
Oncology
Gargi Pal, Jeannette Huaman, Fayola Levine, Akintunde Orunmuyi, E. Oluwabunmi Olapade-Olaopa, Olorunseun O. Ogunwobi
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Chemistry, Multidisciplinary
Prachi Agarwala, Gargi Pal, Satyaprakash Pandey, Souvik Maiti