Article
Biochemistry & Molecular Biology
Guoyao Wu, Xilong Li, Heewon Seo, Bryan A. McLendon, Avery C. Kramer, Fuller W. Bazer, Gregory A. Johnson
Summary: This study demonstrates a novel mechanism of OPN/SPP1 in increasing ion transport across the porcine chorioallantoic placenta by binding to integrins.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Immunology
Elliot Yi-Hsin Lin, Wen Xi, Nupur Aggarwal, Mari L. Shinohara
Summary: Osteopontin (OPN) is a multifunctional protein with various functions in both peripheral immune system and central nervous system (CNS). It is involved in mediating osteoblast adhesion and is associated with inflammatory conditions, infections, allergies, autoimmunity, tissue damage, and CNS diseases and development. However, mechanisms underlying OPN's functions in the CNS are not fully understood.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Cell Biology
Katyana Amilca-Seba, Tuan Zea Tan, Jean-Paul Thiery, Lila Louadj, Sandrine Thouroude, Anais Bouygues, Michele Sabbah, Annette K. Larsen, Jerome A. Denis
Summary: The expression of the transcription factor Slug/SNAI2 is associated with the aggressiveness and metastasis of colorectal cancer. The study reveals that Slug can regulate the expression of osteopontin, a protein involved in colorectal cancer progression. Furthermore, Slug expression and osteopontin secretion are correlated both in vitro and in vivo. These findings suggest that liquid biopsies may provide a valuable biomarker for estimating the aggressiveness phenotype of colorectal tumors.
Article
Virology
Michinori Ishitoku, Sho Mokuda, Kei Araki, Hirofumi Watanabe, Hiroki Kohno, Tomohiro Sugimoto, Yusuke Yoshida, Takemasa Sakaguchi, Junya Masumoto, Shintaro Hirata, Eiji Sugiyama
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes ACE2 and NRP1 to enter host cells. The function of NRP2, another isoform of NRP1, in COVID-19 has rarely been reported. This study aims to clarify the roles of proinflammatory cytokines in NRP expressions and SARS-CoV-2 infection.
Article
Oncology
Yafei Liu, Guanchao Ye, Bo Dong, Lan Huang, Chunyang Zhang, Yinliang Sheng, Bin Wu, Lu Han, Chunli Wu, Yu Qi
Summary: This study provides a comprehensive overview of the role of SPP1 in various cancer types, suggesting it is an important player and a potential prognostic marker in different types of cancer.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sandra Sagmeister, Juliane Merl-Pham, Agnese Petrera, Cornelia A. Deeg, Stefanie M. Hauck
Summary: Using a quantitative proteomic workflow, this study revealed significant changes in the proteome of retinal Muller glial cells under high glucose treatment, particularly in proteins involved in extracellular matrix remodeling, indicating a rapid response to high glucose. The downregulation of Osteopontin and its interacting integrins suggests a potential neuroprotective role of RMG in early neurodegenerative processes in diabetic retinopathy. Data from the study is available through ProteomeXchange with identifier PXDO15879.
Article
Genetics & Heredity
Sarah Foerster, Maryam Givehchi, Katja Nitschke, Thomas Mayr, Kerstin Kilian, Samikshan Dutta, Kaustubh Datta, Philipp Nuhn, Zoran Popovic, Michael H. Muders, Philipp Erben
Summary: This study investigates the predictive and biological functions of neuropilin-2 (NRP2) and its transcript variants in patients with muscle-invasive bladder cancer, finding that NRP2A emerges as an independent prognostic marker associated with more aggressive disease. High messenger expression of NRP2, NRP1, PDGFC, and PDGFD are also linked to aggressive disease and reduced survival in this cohort.
Article
Nutrition & Dietetics
Qinggang Xie, Youbo Zhang, Jinlan Zhang, Dongying Cui, Qile Zhou, Mingruo Guo
Summary: During early neurodevelopment, nutrition plays a crucial role in shaping the myelination process and cognitive development of infants. A study was conducted to analyze the effects of specific nutrients (2'-fucosyllactose, osteopontin, and docosahexaenoic acid) on the myelination and cognitive function of neural cells. The results showed that these nutrients had a synergistic effect in promoting the proliferation, maturation, and differentiation of oligodendrocyte progenitor cells. This study provides experimental evidence for further optimization of infant formula.
FRONTIERS IN NUTRITION
(2022)
Article
Oncology
Chu-Fang Chou, Conway C. Huang, Noura Bin Dabil, Pi-Ling Chang
Summary: The study evaluated the differential expression of SPP1/osteopontin (OPN) splice variants in nonmelanoma skin cancer compared to normal skin. Higher levels of certain splice variants were found in cutaneous squamous cell carcinomas (cSCCs) and basal cell carcinomas relative to normal skin.
CANCER INVESTIGATION
(2021)
Article
Cell Biology
Xiaocong Pang, Junling Zhang, Xu He, Yanlun Gu, Bin-zhi Qian, Ran Xie, Wei Yu, Xiaodan Zhang, Teng Li, Xuedong Shi, Ying Zhou, Yimin Cui
Summary: SPP1 plays a crucial role in predicting the development of mCRPC and is closely associated with the malignant progression and enzalutamide resistance in CRPC. Knockdown of SPP1 enhances enzalutamide sensitivity and suppresses invasion and migration of prostate cancer cells. Upregulation of SPP1 is linked to the maintenance of PI3K/AKT and ERK1/2 signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Chemistry, Multidisciplinary
Bin Liu, Yvonne Vonhausen, Alexander Schulz, Claudia Hoebartner, Frank Wuerthner
Summary: The study demonstrated the suitability of the N-(2-aminoethyl)-glycine oligomers backbone for the formation of structurally defined dye stacks, but the peptide backbone cannot direct the formation of a defined duplex architecture upon further extension of the oligomer.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Julia Patricia Bischoff, Alexander Schulz, Helen Morrison
Summary: Exosomes, nano-sized extracellular vesicles produced through the endosomal pathway, play a crucial role in cell-to-cell communication by transporting bioactive substances to neighboring cells or distant organs. Utilizing exosomes for treating PNS injuries has potential benefits, and they also serve as important vehicles for physiological systemic crosstalk failures during neuroinflammation or aging.
Article
Environmental Sciences
Matthew D. Shupe, Markus Rex, Byron Blomquist, P. Ola G. Persson, Julia Schmale, Taneil Uttal, Dietrich Althausen, Helene Angot, Stephen Archer, Ludovic Bariteau, Ivo Beck, John Bilberry, Silvia Bucci, Clifton Buck, Matt Boyer, Zoe Brasseur, Ian M. Brooks, Radiance Calmer, John Cassano, Vagner Castro, David Chu, David Costa, Christopher J. Cox, Jessie Creamean, Susanne Crewell, Sandro Dahlke, Ellen Damm, Gijs de Boer, Holger Deckelmann, Klaus Dethloff, Marina Duetsch, Kerstin Ebell, Andre Ehrlich, Jody Ellis, Ronny Engelmann, Allison A. Fong, Markus M. Frey, Michael R. Gallagher, Laurens Ganzeveld, Rolf Gradinger, Juergen Graeser, Vernon Greenamyer, Hannes Griesche, Steele Griffiths, Jonathan Hamilton, Guenther Heinemann, Detlev Helmig, Andreas Herber, Celine Heuze, Julian Hofer, Todd Houchens, Dean Howard, Jun Inoue, Hans-Werner Jacobi, Ralf Jaiser, Tuija Jokinen, Olivier Jourdan, Gina Jozef, Wessley King, Amelie Kirchgaessner, Marcus Klingebiel, Misha Krassovski, Thomas Krumpen, Astrid Lampert, William Landing, Tiia Laurila, Dale Lawrence, Michael Lonardi, Brice Loose, Christof Luepkes, Maximilian Maahn, Andreas Macke, Wieslaw Maslowski, Christopher Marsay, Marion Maturilli, Mario Mech, Sara Morris, Manuel Moser, Marcel Nicolaus, Paul Ortega, Jackson Osborn, Falk Paetzold, Donald K. Perovich, Tuukka Petaja, Christian Pilz, Roberta Pirazzini, Kevin Posman, Heath Powers, Kerri A. Pratt, Andreas Preusser, Lauriane Quelever, Martin Radenz, Benjamin Rabe, Annette Rinke, Torsten Sachs, Alexander Schulz, Holger Siebert, Tercio Silva, Amy Solomon, Anja Sommerfeld, Gunnar Spreen, Mark Stephens, Andreas Stohl, Gunilla Svensson, Janek Uin, Juarez Viegas, Christiane Voigt, Peter von der Gathen, Birgit Wehner, Jeffrey M. Welker, Manfred Wendisch, Martin Werner, ZhouQing Xie, Fange Yue
Summary: With the Arctic rapidly changing, there is a crucial need to observe, understand, and model these changes. The MOSAiC expedition successfully documented and characterized various aspects of the Arctic atmospheric system through a comprehensive observational program. The observations revealed the significant influence of atmospheric variability and highlighted the higher temperatures and moisture near the sea ice edge during summer. The obtained data will support further research and modeling capabilities in the Arctic.
ELEMENTA-SCIENCE OF THE ANTHROPOCENE
(2022)
Article
Cardiac & Cardiovascular Systems
Ruben Evertz, Torben Lange, Soeren J. Backhaus, Alexander Schulz, Bo Eric Beuthner, Rodi Topci, Karl Toischer, Miriam Puls, Johannes T. Kowallick, Gerd Hasenfuss, Andreas Schuster
Summary: This study compared the performance of fully automated and manual data analysis in patients with severe aortic stenosis. The results showed that fully automated biventricular volumetric assessment had similar risk prediction to the conventional manual approach, and it also saved approximately 10 minutes per patient compared to manual analysis.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Benjamin Paassen, Alexander Schulz, Terrence C. Stewart, Barbara Hammer
Summary: In this work, the authors successfully achieved some of the computational capabilities of DNCs using an echo state network with efficient training. The model can recognize all regular languages and performs comparably to fully trained deep versions on typical benchmark tasks for DNCs.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2022)
Article
Chemistry, Multidisciplinary
Adam Yuile, Alexander Schulz, Erik Wiss, Jens Mueller, Steffen Wiese
Summary: This study conducted a theoretical analysis and thermal CFD simulation to evaluate the potential of reactive multilayer systems (rms) in bonding silicon chips and ceramic substrates. The analysis focused on the temperature and liquid fraction contours to understand the bonding process. The results provide valuable information for the design of test substrates in experimental investigations.
APPLIED SCIENCES-BASEL
(2022)
Article
Physics, Multidisciplinary
Amin Padash, Erez Aghion, Alexander Schulz, Eli Barkai, Aleksei Chechkin, Ralf Metzler, Holger Kantz
Summary: We conducted numerical studies on a thermally driven, overdamped particle in the Sinai model with random quenched force field, showing that unbounded motion closely approaches the equilibrium state of finite systems due to time scale separation. Using a fast numerical algorithm, we explored phenomena up to 10^17 steps and studied the time-dependent mean squared displacement, mean energy, and entropy of the probability distribution.
NEW JOURNAL OF PHYSICS
(2022)
Article
Medicine, Research & Experimental
Clara Marie Munz, Henriette Kreher, Alexander Erdbeer, Stefanie Richter, Dana Westphal, Buqing Yi, Rayk Behrendt, Nicole Stanke, Fabian Lindel, Dirk Lindemann
Summary: This study identified the role of HS-PG in enhancing the infectivity of foamy viruses (FVs) and the negative impact of PEI residues on target cell transduction. By generating HS-PG-deficient packaging cell lines through genome engineering, high-titer inhibitor-free FV Env-containing virus supernatants could be successfully produced.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Ruben Evertz, Alexander Schulz, Torben Lange, Soeren J. Backhaus, Dirk Vollmann, Johannes T. Kowallick, Stephan von Haehling, Gerd Hasenfuss, Andreas Schuster
Summary: This study provides the first evidence that COVID-19 mRNA vaccine-associated myocarditis does not exhibit specific cardiac magnetic resonance (CMR) patterns during the acute stage in young male patients. The imaging markers observed were closely related to classical viral myocarditis in our cohort.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Correction
Immunology
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M. C. Boehner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. I. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Roesen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Dermatology
Dana Westphal, Matthias Meinhardt, Konrad Gruetzmann, Lisa Schoene, Julian Steininger, Lena T. Neuhaus, Miriam Wiegel, Daniel Schrimpf, Daniela E. Aust, Evelin Schroeck, Gustavo B. Baretton, Stefan Beissert, Tareq A. Juratli, Gabriele G. Schackert, Jan Gravemeyer, Juergen C. Becker, Andreas von Deimling, Christian Koelsche, Barbara Klink, Friedegund Meier, Alexander Schulz, Michael H. Muders, Michael Seifert
Summary: This study integrated omics data analysis to evaluate the methylomes and transcriptomes of matched melanoma metastases, identifying 38 candidate genes with distinct promoter methylation and gene expression changes in intracranial compared with extracranial metastases. The protein expression of the 11 most promising genes was validated using immunohistochemistry, and significant differences were observed in intracranial metastases. Knockdown of PRKCZ or GRB10 altered protein kinase B expression and decreased the viability of a brain-specific melanoma cell line. These findings provide insights into the molecular mechanisms that differentiate brain metastases and could be targeted for therapy.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Cell Biology
Silke Lambing, Yu Pan Tan, Paraskevi Vasileiadou, Stefan Holdenrieder, Patrick Mueller, Christian Hagen, Stephan Garbe, Rayk Behrendt, Martin Schlee, Jasper G. van den Boorn, Eva Bartok, Marcel Renn, Gunther Hartmann
Summary: Radiotherapy induces DNA damage and activates cell death pathways, but its effectiveness is limited in radioresistant tumors such as melanoma. This study shows that activation of the immune sensing receptor RIG-I can enhance irradiation-induced tumor cell death, leading to improved survival in melanoma models. The results suggest that combining RIG-I ligands with radiotherapy may be a promising approach for treating radioresistant tumors with functional p53 pathways, such as melanoma.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Medicine, General & Internal
Marian Simon Schulz, Cay Bennet Sartorius von Bach, Emilija Marinkovic, Claudia Guenther, Rayk Behrendt, Axel Roers
Summary: As a key enzyme in ribonucleotide excision repair, RNase H2 is crucial for removing single ribonucleotides from DNA to prevent genome damage. Loss of RNase H2 activity is directly linked to the development of autoinflammatory and autoimmune diseases, as well as potential involvement in aging and neurodegeneration. Furthermore, RNase H2 activity can serve as a potential diagnostic and prognostic marker for various types of cancer. However, there is currently no validated method for quantifying RNase H2 activity in clinical settings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Johanna Nelkner, Liren Huang, Timo W. W. Lin, Alexander Schulz, Benedikt Osterholz, Christian Henke, Jochen Blom, Alfred Puehler, Alexander Sczyrba, Andreas Schlueter
Summary: The family Nitrososphaeraceae is important in agricultural microbiomes. Metabolic reconstruction of Thaumarchaeota MAGs from German soil showed their relevance for soil fertility and plant health. This family plays a crucial role in agricultural soil microbial communities.
ENVIRONMENTAL MICROBIOME
(2023)
Article
Oncology
Lisa Dinter, Paula C. Karitzky, Alexander Schulz, Alexander A. Wurm, Marie-Christin Mehnert, Mildred Sergon, Antje Tunger, Mathias Lesche, Rebekka Wehner, Anja Mueller, Theresa Kaeubler, Heike Niessner, Andreas Dahl, Stefan Beissert, Marc Schmitz, Friedegund Meier, Barbara Seliger, Dana Westphal
Summary: This study investigated the combined effects of MEK inhibitors (MEKi) and BRAF inhibitors (BRAFi) on sensitive NRAS-mutant melanoma cells, including their ability to inhibit proliferation, induce apoptosis, and alter the expression of immune modulatory molecules. The study found that BRAFi significantly enhanced the antiproliferative and proapoptotic activity of MEKi, and upregulated the expression of immune relevant molecules in melanoma cells.
INTERNATIONAL JOURNAL OF CANCER
(2023)
