Article
Chemistry, Analytical
Hongwei Chu, Conghui Liu, Jinsen Liu, Jiao Yang, Yingchun Li, Xueji Zhang
Summary: The molecular diagnosis has attracted more attention in infectious disease screening with successful understanding of the human genome, especially in light of the recent COVID-19 outbreak. Point-of-care testing (POCT) can expand the application of molecular diagnosis due to its rapid reply, low cost, and ability to work in decentralized environments, which has led many researchers and commercial institutions to focus on POCT-based biosensing for molecular diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Nanoscience & Nanotechnology
Bhaskar Das, Javier Lou Franco, Natasha Logan, Paramasivan Balasubramanian, Moon Il Kim, Cuong Cao
Summary: Nanozymes have attracted attention for their ability to mimic natural enzymes while overcoming their limitations. They offer advantages such as diverse activities, low cost, high stability, and compatibility, making them suitable for various biosensing applications. Their integration in point-of-care diagnostics shows potential, although challenges remain in achieving truly ASSURED solutions.
NANO-MICRO LETTERS
(2021)
Article
Multidisciplinary Sciences
Kaicheng Deng, Yao Tang, Yan Xiao, Danni Zhong, Hua Zhang, Wen Fang, Liyin Shen, Zhaochuang Wang, Jiazhen Pan, Yuwen Lu, Changming Chen, Yun Gao, Qiao Jin, Lenan Zhuang, Hao Wan, Liujing Zhuang, Ping Wang, Junfeng Zhai, Tanchen Ren, Qiaoling Hu, Meidong Lang, Yue Zhang, Huanan Wang, Min Zhou, Changyou Gao, Lei Zhang, Yang Zhu
Summary: The authors present a flexible, biodegradable photonic device called iCarP for illuminating internal organs and tissues with high controllability and adaptability in terms of spectrum, area, depth, and intensity.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Lip Ket Chin, Jun-Yeong Yang, Benjamin Chousterman, Sunghoon Jung, Do-Geun Kim, Dong-Ho Kim, Seunghun Lee, Cesar M. Castro, Ralph Weissleder, Sung-Gyu Park, Hyungsoon Im
Summary: In this study, an ultrasensitive multiplexed plasmonic sensing technology was developed for rapid quantification of multiple biomarkers in point-of-care settings, which could improve the diagnosis and management of sepsis. The technology integrated chemifluorescence signal enhancement with plasmon-enhanced fluorescence detection, allowing for rapid analysis of cytokine biomarkers with high sensitivity. A plasmonic sensing chip based on nanoparticle-spiked gold nanodimple structures was also developed for direct detection of cytokines in clinical plasma samples.
Review
Chemistry, Multidisciplinary
Laura Pasquardini, Nunzio Cennamo, Francesco Arcadio, Luigi Zeni
Summary: Aptamers have great potential as biorecognition elements in biosensors, especially in optical biosensors. Platforms based on silica and plastic optical fibers are promising for the development of portable and small-sized devices using aptamers for various biological applications.
APPLIED SCIENCES-BASEL
(2022)
Review
Chemistry, Analytical
Hichem Moulahoum, Faezeh Ghorbanizamani, Emine Guler Celik, Suna Timur
Summary: The evolution of biosensors and diagnostic devices has facilitated the development of sensing materials, strategies, and device structures. Polymeric composite materials, with their biocompatibility, flexibility, and low cost, show great promise in future lab-on-chip devices. They can also enhance the sensing capabilities of traditional 2D biosensors.
Review
Chemistry, Analytical
Andrea Bonini, Angela Gilda Carota, Noemi Poma, Federico Maria Vivaldi, Denise Biagini, Daria Bottai, Alessio Lenzi, Arianna Tavanti, Fabio Di Francesco, Tommaso Lomonaco
Summary: Sepsis, a systemic inflammatory dysfunction associated with infectious diseases, is a significant health issue with increasing incidence globally. Traditional diagnostic techniques for sepsis management present challenges, making biosensing technologies a valuable alternative.
Review
Chemistry, Multidisciplinary
Sasya Madhurantakam, Sriram Muthukumar, Shalini Prasad
Summary: Rapid diagnosis of COVID-19 is crucial for controlling its spread, and electrochemical sensor platforms show great potential for detecting COVID-19 biomarkers. Point-of-care sensing allows for convenient detection and quantification of health biomarkers, and electrochemical biosensors play a significant role in this field. Integrating electrochemistry with COVID-19 diagnosis and screening using point-of-care technologies enables portable, user-friendly, and rapid analysis.
Article
Chemistry, Analytical
Misagh Rezapour Sarabi, Sattar Akbari Nakhjavani, Savas Tasoglu
Summary: Microneedles are a promising technology for painless and minimally invasive injections, offering lower tissue damage. By combining biosensors and samples collected with microneedles, portable biosensing applications can be enabled.
Article
Chemistry, Multidisciplinary
Francesco Arcadio, Luigi Zeni, Aldo Minardo, Caterina Eramo, Stefania Di Ronza, Chiara Perri, Girolamo D'Agostino, Guido Chiaretti, Giovanni Porto, Nunzio Cennamo
Summary: In this study, a nanoplasmonic sensor chip based on a gold nanograting was tested using an experimental setup, and the orientation of the nanostripes forming the grating pattern was found to influence the biosensing performance, resulting in a best limit of detection of 23 pM for BSA detection. The longitudinal configuration showed two observable plasmonic phenomena sensitive to different BSA concentration ranges, ranging from pM to μM, which is important for various biochemical sensing applications requiring a wide working range.
Article
Chemistry, Multidisciplinary
Zhuopeng Tang, Xinyi Li, Linjing Tong, Huangsheng Yang, Jiayi Wu, Xiliu Zhang, Ting Song, Siming Huang, Fang Zhu, Guosheng Chen, Gangfeng Ouyang
Summary: The use of MHOFs as a protecting scaffold for organizing biocatalytic cascades has shown superior activity, expanded scope of catalytic substrates, and ultrahigh stability. The study also demonstrates the advantages of MHOF-confined cascades system for point-of-care biosensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Patricia Batista Deroco, Dagwin Wachholz Junior, Lauro Tatsuo Kubota
Summary: The advancement in bioelectronics and micro-and nanofabrication technologies has led to the development of new analytical platforms suitable for rapid and highly sensitive point-of-care (POC) devices, which offer low cost, simplicity, user-friendly performance, and quick accurate results in limited-resource settings.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Sile Deng, Lingfeng Li, Jiaxi Zhang, Yongjun Wang, Zhongchao Huang, Haobin Chen
Summary: In recent years, semiconducting polymer dots (Pdots) have gained significant attention for their exceptional photophysical properties and versatility in various applications. They have been widely used in sensing and imaging in biological medicine due to their large absorption cross section, high brightness, tunable fluorescence emission, excellent photostability, good biocompatibility, facile modification, and regulation. Furthermore, Pdots have shown great promise as optical diagnostic technologies for clinical applications, especially in point-of-care biosensing and in vivo imaging. This review provides an overview of Pdots' preparation and modification strategies, discusses recent progress in the development of Pdots-based optical probes for analytical detection and biomedical imaging, and presents the challenges and future directions for their biomedical applications.
Article
Biochemical Research Methods
Zhenghan Shi, Chaobo Dai, Peixue Deng, Yue Wu, Guang Liu, Zijian An, Hao Liang, Fenni Zhang, Yanli Lu, Qingjun Liu
Summary: In this study, a fully integrated handheld smartphone-based photoelectrochemical biosensing system was developed for simultaneous analysis of creatinine and albumin, which are crucial biomarkers for health monitoring. The system utilized graphitic carbon nitride (g-C3N4)/chitosan nanocomposites modified on a transparent indium tin oxide (ITO) electrode as photoactive materials to detect creatinine through chelate formation with copper ion probes, and recognize albumin specifically by an antigen-antibody reaction based on immunoassay. The biosensing system showed good linearity and high sensitivity, with detection ranges of 100μg mL(-1) to 1500μg mL(-1) for creatinine, and 9.9μg mL(-1) to 500μg mL(-1) for albumin. The practical validity of the system was confirmed through testing spiked artificial urine samples with acceptable recovery rates ranging from 98.7% to 105.3%. This portable photoelectrochemical biosensing platform provides a convenient and cost-effective method for biofluid analysis, with promising prospects in point-of-care testing (POCT) for mobile health.
Review
Chemistry, Physical
Giuseppe Mattia Lo Piccolo, Marco Cannas, Simonpietro Agnello
Summary: Silica, as a key material in various technological fields, faces limitations in its widespread application due to radiation-induced point defects. Understanding the structure-reactivity relationship in silica is crucial for predicting optical properties and achieving more efficient devices.