Article
Cardiac & Cardiovascular Systems
Hanjay Wang, Camille E. Hironaka, Danielle M. Mullis, Haley J. Lucian, Hye Sook Shin, Nicholas A. Tran, Akshara D. Thakore, Shreya Anilkumar, Matthew A. Wu, Michael J. Paulsen, Yuanjia Zhu, Sam W. Baker, Y. Joseph Woo
Summary: A neonatal rabbit model of myocardial infarction shows age-dependent natural heart regeneration, but this ability diminishes over time.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Hanjay Wang, Terrence Pong, Oluwatomisin O. Obafemi, Haley J. Lucian, Joy Aparicio-Valenzuela, Nicholas A. Tran, Danielle M. Mullis, Stefan Elde, Yuko Tada, Sam W. Baker, Caroline Y. Wang, Kevin J. Cyr, Michael J. Paulsen, Yuanjia Zhu, Anson M. Lee, Y. Joseph Woo
Summary: Newborn piglets are capable of natural heart regeneration after myocardial infarction (MI) on the first day of birth, but this ability is lost by the seventh day. A study using magnetic resonance imaging and mapping arrays found that the epicardial conduction dynamics are well preserved in the naturally regenerated myocardium.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Hanjay Wang, Andrew Wisneski, Annabel M. Imbrie-Moore, Michael J. Paulsen, Zhongjie Wang, Yue Xuan, Hector Lopez Hernandez, Camille E. Hironaka, Haley J. Lucian, Hye Sook Shin, Shreya Anilkumar, Akshara D. Thakore, Justin M. Farry, Anahita Eskandari, Kiah M. Williams, Frederick Grady, Matthew A. Wu, Jinsuh Jung, Lyndsay M. Stapleton, Amanda N. Steele, Yuanjia Zhu, Y. Joseph Woo
Summary: This study found that neonatal mammals are capable of natural heart regeneration after myocardial infarction (MI), conserving native biaxial left ventricular (LV) mechanics. In contrast, adult mammals exhibit adverse LV remodeling and impaired contractility after MI. This finding provides biomechanical support for the therapeutic potential of cardiac regeneration in the treatment of ischemic heart disease.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Katherine M. Ross Stewart, Sophie L. Walker, Andrew H. Baker, Paul R. Riley, Mairi Brittan
Summary: While humans cannot regenerate their hearts after injury, zebrafish have the ability to fully recover from cardiac insults. The regeneration process in zebrafish involves multiple tissue responses and gene regulatory patterns, with cardiomyocyte regeneration depending on neovascularization and lymphangiogenesis. Studies in zebrafish have provided insights into the mechanisms of cardiovascular repair and regeneration, which can inform strategies for treating human patients with cardiovascular disease.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lisa I. Born, Theresa Andree, Svenja Frank, Judith Huebner, Sandra Link, Marion Langheine, Anne Charlet, Jennifer S. Esser, Ralph Brehm, Martin Moser
Summary: This study found that zebrafish eif4ebp3l plays an important role in vascular development and heart regeneration. Silencing eif4ebp3l promotes angiogenesis in zebrafish, while overexpression of eif4ebp3l alters fibrin deposition in the regenerating heart after injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maria Csobonyeiova, Nikoleta Beerova, Martin Klein, Michaela Debreova-Cehakova, L'ubos Danisovic
Summary: Heart failure is a major cause of morbidity and mortality in modern society due to cardiomyocyte death or dysfunction caused by myocardial infarction. Current therapies for heart failure or myocardial infarction are limited and non-curative. Therefore, research has focused on developing cell-based approaches, such as multipotent stem cells and induced pluripotent stem cells, for myocardial regeneration. Other potential sources for cardiac regeneration include telocytes and cell-free approaches, such as gene therapy and exosomes released from stem cells. This review provides insights into the novel strategies for myocardial repair based on different cell types and cell-free approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Toshiyuki Ko, Seitaro Nomura
Summary: This review summarizes recent studies on manipulating cardiomyocyte plasticity using various approaches such as stem cell differentiation, reprogramming, and reactivation of proliferation as potential treatments for heart disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yanfei Qi, Osama Dasa, Malcolm Maden, Ravneet Vohra, Abhinandan Batra, Glenn Walter, Joshua F. Yarrow, Juan M. Aranda, Mohan K. Raizada, Carl J. Pepine
Summary: The adult spiny mouse's heart displays remarkable recovery properties after acute coronary artery occlusion, making it a potential model for better understanding functional recovery after heart injury. This opens the door to new treatment strategies for millions of patients with heart failure due to tissue damage.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhenbo Han, Xiuxiu Wang, Zihang Xu, Yang Cao, Rui Gong, Yang Yu, Ying Yu, Xiaofei Guo, Shenzhen Liu, Meixi Yu, Wenya Ma, Yiming Zhao, Juan Xu, Xingda Li, Shuainan Li, Yan Xu, Ruijie Song, Binbin Xu, Fan Yang, Djibril Bamba, Natalia Sukhareva, Hong Lei, Manqi Gao, Wenwen Zhang, Naufal Zagidullin, Ying Zhang, Baofeng Yang, Zhenwei Pan, Benzhi Cai
Summary: The study reveals the significant role of m(6)A RNA modification in heart regeneration, with the ALKBH5-m(6)A-YTHDF1-YAP axis regulating cardiomyocytes to re-enter the cell cycle. This finding offers a novel therapeutic strategy for cardiac regeneration.
Article
Veterinary Sciences
Chang Liu, Liangshan Wang, Xianpei Wang, Xiaotong Hou
Summary: In a neonatal mice myocardial infarction model, cardiomyocyte death and heart regeneration were observed, with inflammation playing a crucial role in the process. Inhibition of inflammation by dexamethasone impaired heart regeneration, suggesting that modulating inflammation may provide a promising therapeutic strategy to support heart regeneration.
EXPERIMENTAL ANIMALS
(2021)
Review
Physiology
Florian Weinberger, Thomas Eschenhagen
Summary: The regenerative capacity of the heart is minimal due to the lack of progenitor cell population and the inability of cardiomyocytes to re-enter the cell cycle after birth. Loss of cardiomyocytes can lead to irreversible damage and exacerbate heart failure. Advances in understanding signaling pathways and stem cell technology have provided strategies for potential generation of new myocytes, fulfilling a central criterion for heart repair.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Cardiac & Cardiovascular Systems
Siyuan Ma, Junyu Yan, Dexuan Yang, Wangjun Liao, Jianping Bin, Hairuo Lin, Yulin Liao
Summary: The study shows that using a modified SVR procedure without aggressive purse string suture can persistently alleviate heart failure and improve cardiac regeneration post-MI. The inhibitory effects of SVR on LV remodeling and HF persisted for at least eight weeks, significantly reducing LV volume and improving myocardial function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biology
Ke-Hsuan Wei, I-Ting Lin, Kaushik Chowdhury, Khai Lone Lim, Kuan-Ting Liu, Tai-Ming Ko, Yao-Ming Chang, Kai-Chien Yang, Shih-Lei (Ben) Lai
Summary: Zebrafish have a robust ability to regenerate their hearts, and the immune system plays a key role in this process. By comparing non-regenerative and regenerative hearts, researchers have identified diverse functions and interactions between macrophages and neutrophils, and identified unique resident macrophages that are necessary for zebrafish heart regeneration.
Article
Multidisciplinary Sciences
Rafael Kramann
Summary: Myocardial infarction, also known as heart attack, is one of the deadliest diseases worldwide. Analyzing the changes in human tissue after a heart attack, both spatially and at the single-cell level, provides valuable insights into disease mechanisms and serves as a resource for therapeutic discoveries.
Review
Cardiac & Cardiovascular Systems
Amirala Bakhshian Nik, Santiago Alvarez-Argote, Caitlin C. O'Meara
Summary: IL4 and IL13 play a significant role in cardiac regeneration and repair following injury, leading to beneficial outcomes. However, there is still a lack of comprehensive understanding about their molecular and cellular actions in the heart.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michael J. Paulsen, Annabel M. Imbrie-Moore, Hanjay Wang, Jung Hwa Bae, Camille E. Hironaka, Justin M. Farry, Haley J. Lucian, Akshara D. Thakore, John W. MacArthur, Mark R. Cutkosky, Y. Joseph Woo
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Annabel M. Imbrie-Moore, Michael J. Paulsen, Yuanjia Zhu, Hanjay Wang, Haley J. Lucian, Justin M. Farry, John W. MacArthur, Michael Ma, Y. Joseph Woo
Summary: The study successfully developed a cross-species ex vivo model to simulate Barlow's disease. Repair of the regurgitant valves resulted in reduced mitral leakage volume and decreased chordal forces, providing insight into the biomechanics of the disease.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cell & Tissue Engineering
Yuanjia Zhu, Akshara D. Thakore, Justin M. Farry, Jinsuh Jung, Shreya Anilkumar, Hanjay Wang, Annabel M. Imbrie-Moore, Matthew H. Park, Nicholas A. Tran, Yi-Ping Joseph Woo
Summary: This study demonstrated that rapid mechanical property augmentation of monolayer fibroblast cell sheets can be achieved by treating them with collagen I in a concentration-dependent manner. This methodology has the potential to improve the ease of construct manipulation in cell sheet technology and enable new translational tissue engineering applications.
TISSUE ENGINEERING PART A
(2021)
Article
Cardiac & Cardiovascular Systems
Yuanjia Zhu, Annabel M. Imbrie-Moore, Michael J. Paulsen, Bryant Priromprintr, NlattheIN H. Park, Hanjay Wang, Haley J. Lucian, Justin M. Farry, Y. Joseph Woo
Summary: The study successfully developed a disease model that mimics human aortic regurgitation by inducing cusp prolapse, allowing for accurate examination of valve biomechanics and surgical repair techniques.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Andreas R. de Biasi, Hanjay Wang, Melissa G. Medina, Elan Burton, W. David Ogden
Summary: Pulmonary artery dissection, though rare, can be lethal. Surgical repair may yield good outcomes in selected patients, but postoperative right ventricular failure and death are possible. Only one patient over the age of 60 has been reported to survive open surgical repair, using a composite valve-tube graft.
JOURNAL OF CARDIAC SURGERY
(2021)
Review
Biotechnology & Applied Microbiology
Hye Sook Shin, Heather Hyeyoon Shin, Yasuhiro Shudo
Summary: Establishing an appropriate disease model, frequent modifications to surgical procedures, and insufficient transparency in reporting are three major inhibitors in current preclinical myocardial infarction research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hanjay Wang, Camille E. Hironaka, Danielle M. Mullis, Haley J. Lucian, Hye Sook Shin, Nicholas A. Tran, Akshara D. Thakore, Shreya Anilkumar, Matthew A. Wu, Michael J. Paulsen, Yuanjia Zhu, Sam W. Baker, Y. Joseph Woo
Summary: A neonatal rabbit model of myocardial infarction shows age-dependent natural heart regeneration, but this ability diminishes over time.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Engineering, Biomedical
Hanjay Wang, Andrew Wisneski, Annabel M. Imbrie-Moore, Michael J. Paulsen, Zhongjie Wang, Yue Xuan, Hector Lopez Hernandez, Camille E. Hironaka, Haley J. Lucian, Hye Sook Shin, Shreya Anilkumar, Akshara D. Thakore, Justin M. Farry, Anahita Eskandari, Kiah M. Williams, Frederick Grady, Matthew A. Wu, Jinsuh Jung, Lyndsay M. Stapleton, Amanda N. Steele, Yuanjia Zhu, Y. Joseph Woo
Summary: This study found that neonatal mammals are capable of natural heart regeneration after myocardial infarction (MI), conserving native biaxial left ventricular (LV) mechanics. In contrast, adult mammals exhibit adverse LV remodeling and impaired contractility after MI. This finding provides biomechanical support for the therapeutic potential of cardiac regeneration in the treatment of ischemic heart disease.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Education, Scientific Disciplines
Deven C. Patel, Hanjay Wang, Simar S. Bajaj, Kiah M. Williams, Joshua M. Pickering, Joseph C. Heiler, Keerthi Manjunatha, Christian T. O'Donnell, Mark Sanchez, Jack H. Boyd, Leah M. Backhus
Summary: This study aimed to investigate the impact of an advanced clinical fellowship on the research productivity and academic career advancement of general thoracic surgeons. The study found that completing an advanced clinical fellowship did not lead to significant differences in research productivity and academic rank compared to those who did not pursue additional training.
JOURNAL OF SURGICAL EDUCATION
(2022)
Article
Cell & Tissue Engineering
Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian, Lauren E. Woodard
Summary: This study successfully derived podocytes from human-induced pluripotent stem cells using a accelerated 12-day protocol. The derived podocytes showed comparable marker expression and morphology to longer cultured podocytes. These podocytes can be used for modeling diabetic kidney disease.
STEM CELL RESEARCH & THERAPY
(2022)