Cellular and Molecular Differences between HFpEF and HFrEF: A Step Ahead in an Improved Pathological Understanding

Non-cardiac comorbidities and mortality in patients with heart failure with reduced vs. preserved ejection fraction: a study using the Swedish Heart Failure Registry

(2019) Constantinos Ergatoudes et al.   Clinical Research in Cardiology

Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction

(2019) Jasper Tromp et al.   DIABETES CARE

Endothelial Dysfunction in Chronic Heart Failure: Assessment, Findings, Significance, and Potential Therapeutic Targets

(2019) Manal Alem   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling

(2018) Caojian Zuo et al.   CARDIOVASCULAR RESEARCH

Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1Novelty and Significance

(2018) Anna-Eliane Hopf et al.   CIRCULATION RESEARCH

Titin cardiomyopathy leads to altered mitochondrial energetics, increased fibrosis and long-term life-threatening arrhythmias

(2018) Job A J Verdonschot et al.   EUROPEAN HEART JOURNAL

Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction

(2018) Koen W. Streng et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiac macrophages promote diastolic dysfunction

(2018) Maarten Hulsmans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Distinct Myocardial Targets for Diabetes Therapy in Heart Failure With Preserved or Reduced Ejection Fraction

(2018) Walter J. Paulus et al.   JACC-Heart Failure

Temporal Trends in the Incidence of and Mortality Associated With Heart Failure With Preserved and Reduced Ejection Fraction

(2018) Connie W. Tsao et al.   JACC-Heart Failure

The interstitium in cardiac repair: role of the immune–stromal cell interplay

(2018) Elvira Forte et al.   Nature Reviews Cardiology

High-sensitivity C-reactive protein in heart failure with preserved ejection fraction

(2018) Hilary M. DuBrock et al.   PLoS One

A comprehensive population-based characterization of heart failure with mid-range ejection fraction

(2017) Angela S. Koh et al.   EUROPEAN JOURNAL OF HEART FAILURE

HFpEF and HFrEF Display Different Phenotypes as Assessed by IGF-1 and IGFBP-1

(2017) Ulrika Ljung Faxén et al.   JOURNAL OF CARDIAC FAILURE

The Renin Angiotensin Aldosterone System in Obesity and Hypertension

(2017) Peminda K. Cabandugama et al.   MEDICAL CLINICS OF NORTH AMERICA

Papel del colágeno miocárdico en la estenosis aórtica grave con fracción de eyección conservada y síntomas de insuficiencia cardiaca

(2017) Kattalin Echegaray et al.   REVISTA ESPANOLA DE CARDIOLOGIA

Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in women

(2016) Janet Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

(2016) Antoine H. Chaanine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals

(2016) Jelena S Bezbradica et al.   Cellular & Molecular Immunology

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Extent of Vascular Remodeling Is Dependent on the Balance Between Estrogen Receptor α and G-Protein–Coupled Estrogen ReceptorNovelty and Significance

(2016) Robert Gros et al.   HYPERTENSION

Differences in biochemical and genetic biomarkers in patients with heart failure of various etiologies

(2016) Agata Bielecka-Dabrowa et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Understanding heart failure with preserved ejection fraction: where are we today?

(2016) L. van Heerebeek et al.   Netherlands Heart Journal

Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction

(2016) Constantijn Franssen et al.   JACC-Heart Failure

Precipitating Clinical Factors, Heart Failure Characterization, and Outcomes in Patients Hospitalized With Heart Failure With Reduced, Borderline, and Preserved Ejection Fraction

(2016) John R. Kapoor et al.   JACC-Heart Failure

Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity

(2016) Manlio Vinciguerra et al.   Aging-US

Monocytes in Myocardial Infarction

(2015) P. Dutta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting metabolic disturbance in the diabetic heart

(2015) Jesús Fuentes-Antrás et al.   Cardiovascular Diabetology

Myocardial Stiffness in Patients With Heart Failure and a Preserved Ejection Fraction: Contributions of Collagen and Titin

(2015) M. R. Zile et al.   CIRCULATION

Diastolic Dysfunction

(2015) Euy-Myoung Jeong et al.   CIRCULATION JOURNAL

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?

(2015) Matthias Nahrendorf et al.   EUROPEAN HEART JOURNAL

Exaggerated Inflammation and Monocytosis Associate With Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction: Evidence of M2 Macrophage Activation in Disease Pathogenesis

(2015) Nadezhda Glezeva et al.   JOURNAL OF CARDIAC FAILURE

Viral myocarditis—diagnosis, treatment options and current controversies

(2015) Ari Pollack et al.   Nature Reviews Cardiology

Gigantic Business

(2014) Wolfgang A. Linke et al.   CIRCULATION RESEARCH

Fibrosis Marker Syndecan-1 and Outcome in Patients With Heart Failure With Reduced and Preserved Ejection Fraction

(2014) Jasper Tromp et al.   Circulation-Heart Failure

The Global Health and Economic Burden of Hospitalizations for Heart Failure

(2014) Andrew P. Ambrosy et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chronic Kidney Disease and Outcomes in Heart Failure With Preserved Versus Reduced Ejection Fraction

(2013) David H. Smith et al.  

Myocardial Titin Hypophosphorylation Importantly Contributes to Heart Failure With Preserved Ejection Fraction in a Rat Metabolic Risk Model

(2013) Nazha Hamdani et al.   Circulation-Heart Failure

Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND

(2013) F. P. Brouwers et al.   EUROPEAN HEART JOURNAL

Nitroso-Redox Imbalance Affects Cardiac Structure and Function**Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.

(2013) Vasileios Karantalis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts

(2013) Vennece Fowlkes et al.   LIFE SCIENCES

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

(2013) Yasmine Zouggari et al.   NATURE MEDICINE

Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction

(2012) Nazha Hamdani et al.   CARDIOVASCULAR RESEARCH

Low Myocardial Protein Kinase G Activity in Heart Failure With Preserved Ejection Fraction

(2012) Loek van Heerebeek et al.   CIRCULATION

Predictors of New-Onset Heart Failure

(2012) Jennifer E. Ho et al.   Circulation-Heart Failure

Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes

(2012) Huriya Beyan et al.   DIABETES

Vascular Function and the Role of Oxidative Stress in Heart Failure, Heart Transplant, and Beyond

(2012) Melissa A.H. Witman et al.   HYPERTENSION

Bone marrow-derived cells contribute to cell turnover in aging murine hearts

(2012) SEBASTIAN SZARDIEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Coronary perivascular fibrosis is associated with impairment of coronary blood flow in patients with non-ischemic heart failure

(2012) Zhehao Dai et al.   Journal of Cardiology

Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction

(2012) Sameer Ather et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Endothelial Dysfunction, Arterial Stiffness, and Heart Failure

(2012) Catherine N. Marti et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Republished: Healing and adverse remodelling after acute myocardial infarction: role of the cellular immune response

(2012) Anja M van der Laan et al.   POSTGRADUATE MEDICAL JOURNAL

Oxidative stress and heart failure

(2011) Hiroyuki Tsutsui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

(2011) Ting-Ting Tang et al.   BASIC RESEARCH IN CARDIOLOGY

Antiproliferative effect of estrogen in vascular smooth muscle cells is mediated by Kruppel-like factor-4 and manganese superoxide dismutase

(2011) Derya Sivritas et al.   BASIC RESEARCH IN CARDIOLOGY

Prevalence and Significance of Alterations in Cardiac Structure and Function in Patients With Heart Failure and a Preserved Ejection Fraction

(2011) Michael R. Zile et al.   CIRCULATION

Prognostic Impact of Myocardial Interstitial Fibrosis in Non-Ischemic Heart Failure

(2011) Tatsuo Aoki et al.   CIRCULATION JOURNAL

Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure

(2011) Jasper W.L. Hartog et al.   EUROPEAN JOURNAL OF HEART FAILURE

Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?

(2011) Patrick Collier et al.   EUROPEAN JOURNAL OF HEART FAILURE

Viral myocarditis: potential defense mechanisms within the cardiomyocyte against virus infection

(2011) Toshitaka Yajima   Future Microbiology

Diastolic Tissue Doppler Indexes Correlate With the Degree of Collagen Expression and Cross-Linking in Heart Failure and Normal Ejection Fraction

(2011) Mario Kasner et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

New Targets to Treat the Structural Remodeling of the Myocardium

(2011) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man

(2011) Andrew J Boyle et al.   Journal of Translational Medicine

Titin is a Target of Matrix Metalloproteinase-2

(2010) Mohammad A.M. Ali et al.   CIRCULATION

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1α and MCP-1 levels in type 2 diabetic patients

(2010) Pei-chun Chao et al.   EUROPEAN JOURNAL OF NUTRITION

Insulin signaling regulates cardiac titin properties in heart development and diabetic cardiomyopathy

(2010) Martina Krüger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy

(2010) Sandra B. Haudek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inflammatory Markers and Incident Heart Failure Risk in Older Adults

(2010) Andreas Kalogeropoulos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing

(2009) Amy D. Bradshaw et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy, Redox Signaling, and Ventricular Remodeling

(2009) Narasimman Gurusamy et al.   ANTIOXIDANTS & REDOX SIGNALING

Relation of Disease Pathogenesis and Risk Factors to Heart Failure With Preserved or Reduced Ejection Fraction

(2009) Douglas S. Lee et al.   CIRCULATION

Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function

(2009) Amy D. Bradshaw et al.   CIRCULATION

Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium

(2009) Attila Borbély et al.   CIRCULATION RESEARCH

Prognostic value of apoptosis markers in advanced heart failure patients

(2009) A. Niessner et al.   EUROPEAN HEART JOURNAL

Circulating Estradiol and Mortality in Men With Systolic Chronic Heart Failure

(2009) Ewa A. Jankowska   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antioxidant effect of estrogen on bovine aortic endothelial cells

(2009) Jae-Yen Song et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition?

(2009) Karen A. Matthews et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

The Role of Leukocyte-Generated Oxidants in Left Ventricular Remodeling

(2008) Marc S. Penn   AMERICAN JOURNAL OF CARDIOLOGY

Usefulness of the Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality in ST Segment Elevation Myocardial Infarction

(2008) Julio Núñez et al.   AMERICAN JOURNAL OF CARDIOLOGY

Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling

(2008) G. W. Dorn   CARDIOVASCULAR RESEARCH

Role of Left Ventricular Stiffness in Heart Failure With Normal Ejection Fraction

(2008) Dirk Westermann et al.   CIRCULATION

Progestins oppose the effects of estradiol on the endothelin-1 receptor type B in coronary arteries from ovariectomized hyperlipidemic rabbits

(2008) Susan H. Pedersen et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy

(2007) Makoto Kobayashi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY