Article
Neurosciences
Seema Banerjee, Qing Wang, George Tang, ChungHim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
Summary: Our study demonstrated an increase in phosphorylation of connexin35 at Ser276 in both 12-hour and 7-day stages of lens-induced myopia in cone-dominant chicken retinas, potentially leading to increased coupling with AII amacrine cells.
VISUAL NEUROSCIENCE
(2021)
Article
Neurosciences
Joseph Pottackal, Hannah L. Walsh, Pouyan Rahmani, Kathy Zhang, Nicholas J. Justice, Jonathan B. Demb
Summary: In this study, a circuitry was identified in mice that allows M5 ipRGCs to locally inhibit retinal neurons by forming electrical synapses with nonspiking GABAergic amacrine cells. The results demonstrate a functional role for electrical synapses in translating ipRGC activity into feedforward and feedback inhibition of local retinal circuits.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Qin Wang, Seema Banerjee, ChungHim So, ChunTing Qiu, YingHon Sze, Thomas Chuen Lam, Chi-Ho To, Feng Pan
Summary: Low-dose atropine has been shown to effectively control myopia progression with minimal side effects. However, the impact of atropine on retinal ganglion cells (RGCs) remains unclear. Direct application of atropine on the retina affected the light-evoked responses of ON and OFF alpha RGCs in a dose- and time-dependent manner, but lower concentrations did not disrupt synchronized firing patterns between RGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Silke Haverkamp, Laszlo Albert, Vaishnavi Balaji, Pavel Nemec, Karin Dedek
Summary: In this study, various transcription factors were tested in two avian species, revealing their crucial role in the ganglion cells of birds. The markers established may serve as valuable tools for further detailed studies on the retinal circuitry of these highly visual animals.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Takuma Maruyama, Toshiyuki Ishii, Makoto Kaneda
Summary: This study investigated whether gap junctional coupling occurs between starburst amacrine cells (SACs) during the developmental stage in the mouse retina. The results showed that SACs were coupled with neighboring cells, mainly retinal ganglion cells, before eye-opening. However, this coupling decreased significantly after eye-opening and disappeared by postnatal day 28 (P28). These findings suggest that gap junctional coupling by SACs occurs during development and is regulated by intrinsic factors.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Jongsu Choi, Jin Li, Salma Ferdous, Qingnan Liang, Jeffrey R. Moffitt, Rui Chen
Summary: This study generated a spatial atlas of the mouse retina using MERFISH technique, revealing the spatial arrangement of almost all cell subtypes in the retina and the connection between molecular classification and spatial arrangement. It also identified previously unknown cell subtypes and discovered spatially dependent differential gene expression between subtypes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Uwe Thorsten Lux, Johanna Ehrenberg, Anneka Joachimsthaler, Jenny Atorf, Bianca Pircher, Kerstin Reim, Jan Kremers, Andreas Giessl, Johann Helmut Brandstaetter
Summary: The study found that Cplx 2, not Cplx 1, is the main isoform expressed in mouse retinas, and knockout of Cplx 1 altered retinal function. These results provide an important basis for future research on the function of Cplxs 1 and 2 in processing visual signals in the mammalian retina.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lei Gu, Jacky M. K. Kwong, Joseph Caprioli, Natik Piri
Summary: Rbfox1 is associated with neurodevelopmental and neurological conditions, as well as age-related neurodegenerative diseases. This study showed that 22-month-old Rbfox1 KO mice had visual function deficiencies and normal retinal morphology, with no effect on the survival of injured RGCs.
Article
Neurosciences
Todd Stincic, Jacqueline Gayet-Primo, W. Rowland Taylor, Teresa Puthussery
Summary: The study shows that TARP gamma 2 is associated with AMPARs in the synaptic layers of the retina in different species. Lack of TARP gamma 2 expression in stargazer mice leads to reduced synaptic expression of GluA2, GluA3, and GluA4 and smaller light-evoked EPSCs in ON-SACs. This suggests that TARP gamma 2 is required for normal synaptic expression and function of AMPARs in the inner retina.
Article
Neurosciences
Lei Gu, Jacky M. Kwong, Joseph Caprioli, Natik Piri
Summary: Rbfox1 is a multifunctional RNA binding protein that plays key roles in regulating alternative splicing and cell survival under stress. Deletion of Rbfox1 in retinal ganglion cells results in decreased survival and severe degeneration, indicating its importance in neuronal functions and survival mechanisms.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Silke Haverkamp, Matthias Mietsch, Kevin L. Briggman
Summary: This study provides a first-time description of the structural characteristics and morphological differences of the common marmoset retina. The finding of misplaced ganglion cells and misplaced bipolar cell axon terminals has important implications for future research on the physiological and functional impact.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyu Liu, Mingru Bai, Yimin Sun, Xuchen Hu, Chenglin Wang, Jing Xie, Ling Ye
Summary: In osteoblasts, FGF7 promotes the expression of E11, leading to dendrites elongation and the formation of functional gap junctions through connexin43 (Cx43) interaction. This process is mediated by the MAPK pathway and PI3K-AKT pathway, suggesting a significant role of FGF7 in later stages of bone development and homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tamas Kovacs-Oller, Gergely Szarka, Gyula Hoffmann, Loretta Pentek, Greta Valentin, Liliana Ross, Bela Volgyi
Summary: Gap junctions and connexin proteins undergo major changes in degenerating retinal tissue. It is important to distinguish these adaptive changes from alterations following tissue deterioration.
Article
Ophthalmology
Agustina Noailles, Oksana Kutsyr, Aloma Mayordomo-Febrer, Pedro Lax, Maria Lopez-Murcia, Silvia M. Sanz-Gonzalez, Maria Dolores Pinazo-Duran, Nicolas Cuenca
Summary: By studying a rat model of chronic glaucoma, it was found that intraocular injections of sodium hyaluronate result in increased intraocular pressure and changes in retinal morphology, similar to the characteristics of human open-angle glaucoma.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Neurosciences
Pablo Beltran-Matas, Espen Hartveit, Margaret L. Veruki
Summary: The NMDA receptors expressed by AII and A17 amacrine cells in the mammalian retina are extrasynaptic and molecularly distinct, being activated by different sources of glutamate and endogenous co-agonists. The differential and independent activation of these receptors likely play specific roles in signal processing and plasticity of the rod pathway microcircuit.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Seema Banerjee, Qin Wang, Fuxin Zhao, George Tang, Chunghim So, Dennis Tse, Chi-Ho To, Yun Feng, Xiangtian Zhou, Feng Pan
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Ophthalmology
Rohit C. Khanna, Srinivas Marmamula, Maria Vittoria Cicinelli, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare E. Gilbert, Gullapalli Nageswara Rao
Summary: The incidence rate of pterygium is higher in rural populations, particularly among men, outdoor workers, individuals with low education levels, and those with lower body mass index (BMI). Greater exposure to ultraviolet light is a major contributing factor to the increased risk of developing pterygium in these populations, highlighting the need for preventive strategies.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Rohit C. Khanna, Srinivas Marmamula, Pooja Pendri, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare Gilbert, Gullapalli N. Rao
Summary: The high incidence of visual loss in rural participants of APEDS III study is mainly attributed to cataract and uncorrected refractive errors. Significant independent risk factors for incident visual loss include increasing age, female gender, illiteracy, past or current smoking, and current alcohol use, with lower levels of education being an additional risk factor according to the USA definition.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qin Wang, Seema Banerjee, Chunghim So, Chunting Qiu, Hang-I Christie Lam, Dennis Tse, Bela Volgyi, Feng Pan
Article
Ophthalmology
Nikhil S. Choudhari, Rohit C. Khanna, Srinivas Marmamula, Asha Latha Mettla, Pyda Giridhar, Seema Banerjee, Konegari Shekhar, Subhabrata Chakrabarti, Gudlavalleti V. S. Murthy, Clare Gilbert, Gullapalli N. Rao
Summary: This study reported the long-term incidence of PACD in rural India, with female gender identified as a significant risk factor and myopia as a protective factor.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Neurosciences
Qin Wang, Seema Banerjee, ChungHim So, ChunTing Qiu, YingHon Sze, Thomas Chuen Lam, Chi-Ho To, Feng Pan
Summary: Low-dose atropine has been shown to effectively control myopia progression with minimal side effects. However, the impact of atropine on retinal ganglion cells (RGCs) remains unclear. Direct application of atropine on the retina affected the light-evoked responses of ON and OFF alpha RGCs in a dose- and time-dependent manner, but lower concentrations did not disrupt synchronized firing patterns between RGCs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Samuel Abokyi, Sze-Wan Shan, Christie Hang- Lam, Kirk Patrick Catral, Feng Pan, Henry Ho-Lung Chan, Chi-Ho To, Dennis Yan-Yin Tse
Summary: This study found that lysosomal dysfunction and autophagy defects underlie oxidative damage induced by HQ in human RPE cells, and supports lysosomal stabilization with the proteasome inhibitor MG132 as a potential remedy for oxidative damage in RPE and AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Correction
Neurosciences
Seema Banerjee, Qin Wang, George Tang, ChungHim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
VISUAL NEUROSCIENCE
(2021)
Article
Neurosciences
Seema Banerjee, Qing Wang, George Tang, ChungHim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
Summary: Our study demonstrated an increase in phosphorylation of connexin35 at Ser276 in both 12-hour and 7-day stages of lens-induced myopia in cone-dominant chicken retinas, potentially leading to increased coupling with AII amacrine cells.
VISUAL NEUROSCIENCE
(2021)