The Role of Gamma Delta T Cells in Autoimmune Rheumatic Diseases

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

(2020) Jérôme Le Nours et al.   SCIENCE

A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation

(2019) Yunyun Yang et al.   IMMUNITY

γδ T Cell Update: Adaptate Orchestrators of Immune Surveillance

(2019) Adrian C. Hayday   JOURNAL OF IMMUNOLOGY

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

(2018) Pedro H. Papotto et al.   JOURNAL OF AUTOIMMUNITY

γδ T cell responses: How many ligands will it take till we know?

(2018) David Vermijlen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis

(2018) Laura Bouchareychas et al.   Scientific Reports

Prevalence and Characteristics of Persistent Clonal T-LGL Expansions in Rheumatoid Arthritis: a Comprehensive Analysis of 529 Patients

(2018) Eva C. Schwaneck et al.   Arthritis & Rheumatology

Involvement of T helper 17 cells in inflammatory arthritis depends on the host intestinal microbiota

(2018) Heather Evans-Marin et al.   Arthritis & Rheumatology

Dysregulated CD25 and Cytokine Expression by γδ T Cells of Systemic Sclerosis Patients Stimulated With Cardiolipin and Zoledronate

(2018) Helena Migalovich Sheikhet et al.   Frontiers in Immunology

Increased IL-22- and IL-17A-Producing Mucosal-Associated Invariant T Cells in the Peripheral Blood of Patients With Ankylosing Spondylitis

(2018) Éric Toussirot et al.   Frontiers in Immunology

γδ T cells control humoral immune response by inducing T follicular helper cell differentiation

(2018) Rafael M. Rezende et al.   Nature Communications

The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness

(2018) Daisy Melandri et al.   NATURE IMMUNOLOGY

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

(2018) Koen Venken et al.   Nature Communications

Brief Report: Innate lymphoid cells and T-cells contribute to the IL-17A signature detected in the synovial fluid of patients with Juvenile Idiopathic Arthritis

(2018) Elizabeth C Rosser et al.   Arthritis & Rheumatology

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

(2017) M. H. Al-Mossawi et al.   Nature Communications

Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells

(2017) Mariángeles Noto Llana et al.   Frontiers in Cellular and Infection Microbiology

Proinflammatory Cytokine Environments Can Drive Interleukin-17 Overexpression by γ/δ T Cells in Systemic Juvenile Idiopathic Arthritis

(2017) Christoph Kessel et al.   Arthritis & Rheumatology

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients

(2016) Ana Henriques et al.   INFLAMMATION RESEARCH

CD4+B220+TCRγδ+ T cells produce IL-17 in lupus-prone MRL/lpr mice

(2016) Feng Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gamma Delta T Cell Subset V Gamma 2+ Expansion Associated with Longterm Infliximab Treatment in a Patient with Ankylosing Spondylitis

(2016) E. GRACEY et al.   JOURNAL OF RHEUMATOLOGY

IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases

(2016) J.-H. Riedel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interleukin-23-Dependent γ/δ T Cells Produce Interleukin-17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice

(2016) Annika Reinhardt et al.   Arthritis & Rheumatology

Association of γδ T Cell Compartment Size to Disease Activity and Response to Therapy in SLE

(2016) Hongshuang Ma et al.   PLoS One

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

(2016) Xiaohua Xue et al.   Scientific Reports

Clinicopathologic, Immunophenotypic, Cytogenetic, and Molecular Features of γδ T-Cell Large Granular Lymphocytic Leukemia: An Analysis of 14 Patients Suggests Biologic Differences With γδ T-Cell Large Granular Lymphocytic Leukemia

(2015) Mariko Yabe et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Human gamma delta T cells: Evolution and ligand recognition

(2015) Erin J. Adams et al.   CELLULAR IMMUNOLOGY

Natural killer cell and gamma delta T cell alterations in enthesitis related arthritis category of juvenile idiopathic arthritis

(2015) Priyanka Gaur et al.   CLINICAL IMMUNOLOGY

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

(2015) Katrina Blazek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells

(2015) Aoi Akitsu et al.   Nature Communications

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

99Tc-methylene diphosphonate improves rheumatoid arthritis disease activity by increasing the frequency of peripheral γδ T cells and CD4+CD25+Foxp3+Tregs

(2014) Dinglei Su et al.   International Journal of Rheumatic Diseases

Reduced B Lymphoid Kinase (Blk) Expression Enhances Proinflammatory Cytokine Production and Induces Nephrosis in C57BL/6-lpr/lpr Mice

(2014) Elizabeth M. Samuelson et al.   PLoS One

Synergistic Effects of Ethanol and Isopentenyl Pyrophosphate on Expansion of γδ T Cells in Synovial Fluid from Patients with Arthritis

(2014) Agneta J. Laurent et al.   PLoS One

Mannan induces ROS-regulated, IL-17A-dependent psoriasis arthritis-like disease in mice

(2014) I. Khmaladze et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of CD161+ Vδ1+ γδ T cells in systemic sclerosis: association with interstitial pneumonia

(2014) Seiji Segawa et al.   RHEUMATOLOGY

Systemic Juvenile Idiopathic Arthritis-like Syndrome in Mice Following Stimulation of the Immune System With Freund's Complete Adjuvant: Regulation by Interferon-γ

(2014) Anneleen Avau et al.   Arthritis & Rheumatology

A Novel Prothrombotic Pathway in Systemic Sclerosis Patients: Possible Role of Bisphosphonate-Activated γδ T Cells

(2014) Victoria Marcu-Malina et al.   Frontiers in Immunology

Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications

(2013) Ilan Bank et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites

(2012) Miguel A. Pineda et al.   ARTHRITIS AND RHEUMATISM

Circulating γ/δ T cells in systemic sclerosis exhibit activated phenotype and enhance gene expression of proalpha2(I) collagen of fibroblasts

(2012) Ikuko Ueda-Hayakawa et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Cellular Interactions of Synovial Fluid    T Cells in Juvenile Idiopathic Arthritis

(2012) A. Bendersky et al.   JOURNAL OF IMMUNOLOGY

Downregulation of CD94/NKG2A Inhibitory Receptor on Decreased γδ T Cells in Patients with Systemic Lupus Erythematosus

(2012) L. Wang et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis

(2011) Tony J. Kenna et al.   ARTHRITIS AND RHEUMATISM

Antigen-presenting effects of effector memory Vγ9Vδ2 T cells in rheumatoid arthritis

(2011) Chaoying Hu et al.   Cellular & Molecular Immunology

Th17 Cells, Not IL-17+    T Cells, Drive Arthritic Bone Destruction in Mice and Humans

(2011) B. Pollinger et al.   JOURNAL OF IMMUNOLOGY

Generation of Human Regulatory    T Cells by TCR   Stimulation in the Presence of TGF-  and Their Involvement in the Pathogenesis of Systemic Lupus Erythematosus

(2011) X. Li et al.   JOURNAL OF IMMUNOLOGY

  T cells in Juvenile Idiopathic Arthritis: Higher Percentages of Synovial V 1+ and V 9+ T Cell Subsets Are Associated with Milder Disease

(2011) Y. BERKUN et al.   JOURNAL OF RHEUMATOLOGY

Disparate effects of depletion of CD1d-reactive T cells during early versus late stages of disease in a genetically susceptible model of lupus

(2011) J Jacinto et al.   LUPUS

IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis

(2011) Jian Tao et al.   ARTHRITIS RESEARCH & THERAPY

Analysis of T cell receptors in rheumatoid arthritis: the increased expression of HLA-DR antigen on circulating γδ+ T cells is correlated with disease activity

(2010) A. LAMOUR et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

A high proportion of the Vδ1+ synovial fluid γδ T cells in juvenile rheumatoid arthritis patients express the very early activation marker CD69, but carry the high molecular weight isoform of the leucocyte common antigen (CD45RA)

(2010) J. KJELDSEN-KRAGH et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The cytotoxic analysis of T cell receptor Vδ+ T cell lines derived from the synovial fluid of rheumatoid arthritis patients

(2010) M. OHTA et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Variable gene usage of T cell receptor γ- and δ-chain transcripts expressed in synovia and peripheral blood of patients with rheumatoid arthritis

(2010) C. OLIVE et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis

(2009) Yoshinaga Ito et al.   ARTHRITIS AND RHEUMATISM

Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states

(2009) Claudia Macaubas et al.   CLINICAL IMMUNOLOGY

Vγ9+ γδ T cells in systemic sclerosis patients are numerically and functionally preserved and induce fibroblast apoptosis

(2009) Anna Bendersky et al.   IMMUNOBIOLOGY

The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

(2009) Nicolas Page et al.   PLoS One

Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells

(2009) Ferry Cornelissen et al.   ARTHRITIS RESEARCH & THERAPY

Clinical spectrum of γδ+ T cell LGL leukemia: Analysis of 20 cases

(2007) A.S. Bourgault-Rouxel et al.   LEUKEMIA RESEARCH