(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer (ESWN 01): a prospective randomized, multicenter, open-labeled phase 3 trial

(2019) Jing Huang et al.   Cancer Communications

A novel oral camptothecin analog, gimatecan, exhibits superior antitumor efficacy than irinotecan toward esophageal squamous cell carcinoma in vitro and in vivo

(2018) Jianling Zou et al.   Cell Death & Disease

Hydroxycamptothecin mediates antiproliferative effects through apoptosis and autophagy in A549 cells

(2018) Yanjie Wei et al.   Oncology Letters

Current and future treatment options for esophageal cancer in the elderly

(2017) Elfriede Bollschweiler et al.   EXPERT OPINION ON PHARMACOTHERAPY

10-Hydroxycamptothecin (HCPT) nanosuspensions stabilized by mPEG1000-HCPT conjugate: high stabilizing efficiency and improved antitumor efficacy

(2017) Linjie Yang et al.   International Journal of Nanomedicine

Type I DNA Topoisomerases

(2017) Giovanni Capranico et al.   JOURNAL OF MEDICINAL CHEMISTRY

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Anticancer effects of 10-hydroxycamptothecin induce apoptosis of human osteosarcoma through activating caspase-3, p53 and cytochrome�c pathways

(2017) Xiong Min et al.   Oncology Letters

Phosphorylation of H2A.XTyr39positively regulates DNA damage response and is linked to cancer progression

(2016) Yan Liu et al.   FEBS Journal

In vitro and in vivo anti-tumor efficacy of 10-hydroxycamptothecin polymorphic nanoparticle dispersions: shape- and polymorph-dependent cytotoxicity and delivery of 10-hydroxycamptothecin to cancer cells

(2016) Hongdi Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

The histone variant H2A.X is a regulator of the epithelial–mesenchymal transition

(2016) Urbain Weyemi et al.   Nature Communications

Topoisomerase I in Human Disease Pathogenesis and Treatments

(2016) Min Li et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level

(2014) Joanna Proszek et al.   SENSORS

Epidemiology of esophageal cancer

(2014) Yuwei Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research

(2014) M. Hidalgo et al.   Cancer Discovery

Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression

(2013) Bojian Fei et al.   World Journal of Surgical Oncology

DNA Repair and Resistance to Topoisomerase I Inhibitors: Mechanisms, Biomarkers and Therapeutic Targets

(2012) M. Alagoz et al.   CURRENT MEDICINAL CHEMISTRY

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Topoisomerase I expression in tumors as a biological marker for CPT-11 chemosensitivity in patients with colorectal cancer

(2011) Masahide Ikeguchi et al.   SURGERY TODAY

Albumin attenuates DNA damage in primary-cultured neurons

(2008) Fernando C. Baltanás et al.   NEUROSCIENCE LETTERS