Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan

Smad3 suppresses epithelial cell migration and proliferation via the clock gene Dec1, which negatively regulates the expression of clock genes Dec2 and Per1

(2019) Fuyuki Sato et al.   AMERICAN JOURNAL OF PATHOLOGY

RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression

(2019) Catharina Melzer et al.   Cells

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5

(2019) Hendrik Ungefroren et al.   Cancers

RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition

(2019) Rabea Zinn et al.   Cells

Paving the Rho in cancer metastasis: Rho GTPases and beyond

(2018) Sepp Jansen et al.   PHARMACOLOGY & THERAPEUTICS

Clinico-Pathological Importance of TGF-β/Phospho-Smad Signaling during Human Hepatic Fibrocarcinogenesis

(2018) Katsunori Yoshida et al.   Cancers

TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

(2018) Vincent Drubay et al.   Cancers

Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3

(2018) Jianning Yao et al.   Cancer Cell International

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

(2017) Aleksandra Adamska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b

(2017) David Witte et al.   Scientific Reports

TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma

(2016) A K Thakur et al.   CELL DEATH AND DIFFERENTIATION

Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway

(2015) Cedric Carl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients

(2015) Maria Serova et al.   Oncotarget

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling

(2015) Hendrik Ungefroren et al.   Oncotarget

The prognostic significance of Smad3, Smad4, Smad3 phosphoisoform expression in esophageal squamous cell carcinoma

(2014) Soo Youn Cho et al.   MEDICAL ONCOLOGY

Smad3 regulates E-cadherin via miRNA-200 pathway

(2011) S-M Ahn et al.   ONCOGENE

Phenotype and Genotype of Pancreatic Cancer Cell Lines

(2010) Emily L. Deer et al.   PANCREAS

Angiotensin II Induces Connective Tissue Growth Factor and Collagen I Expression via Transforming Growth Factor–β–Dependent and –Independent Smad Pathways

(2009) Fuye Yang et al.   HYPERTENSION

Role of Smad3, acting independently of transforming growth factor-β, in the early induction of Wnt-β-catenin signaling by parathyroid hormone in mouse osteoblastic cells

(2009) Yoshifumi Inoue et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antitumor Efficacy of Trastuzumab in Nude Mice Orthotopically Xenografted With Human Pancreatic Tumor Cells Expressing Low Levels of HER-2/neu

(2009) Graziella Pratesi et al.   JOURNAL OF IMMUNOTHERAPY

Advanced Glycation End-Products Induce Tubular CTGF via TGF- -Independent Smad3 Signaling

(2009) A. C.K. Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition

(2009) Theresa Vincent et al.   NATURE CELL BIOLOGY