Article
Neurosciences
Zhiqian Yu, Kazuko Ueno, Ryo Funayama, Mai Sakai, Naoki Nariai, Kaname Kojima, Yoshie Kikuchi, Xue Li, Chiaki Ono, Junpei Kanatani, Jiro Ono, Kazuya Iwamoto, Kenji Hashimoto, Kengo Kinoshita, Keiko Nakayama, Masao Nagasaki, Hiroaki Tomita
Summary: This study investigated the transcriptional profiles in the dorsolateral prefrontal cortex (DLPFC) to understand the clinical and biological differences of schizophrenia between males and females. The results showed that females with schizophrenia had more significantly changed genes compared to males, and these changes were mainly related to mitochondrial, ATP- and metal ion-binding relevant biological processes. The differentially expressed genes related to schizophrenia in females were involved in midbrain dopaminergic and GABA-ergic neurons and microglia. Additionally, analysis of a murine model revealed that the methylation and transcriptional expression of the ACSBG1 locus potentially impact the sex differences in gene transcription.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Multidisciplinary Sciences
Xinxing Wu, Chong Peng, Peter T. Nelson, Qiang Cheng
Summary: Alzheimer's disease (AD) and LATE are complex neurodegenerative disorders affecting cognition and behavior. The development of drugs to target these diseases has been slow due to incomplete understanding of associated genes. Analyzing imbalanced data is challenging, but essential for identifying disease-related genes and improving potential treatment strategies.
Article
Geriatrics & Gerontology
Mohini Gharpure, Jie Chen, Resheek Nerella, Sagar Vyavahare, Sandeep Kumar, Carlos M. Isales, Mark Hamrick, Satish Adusumilli, Sadanand Fulzele
Summary: Sarcopenia, a condition characterized by decreased muscle mass, altered muscle composition, and reduced muscle strength, disproportionately affects males and females with age. This study identified differentially regulated genes in aged skeletal muscle from males and females, with 269 genes showing at least a twofold expression difference. Gene Ontology analysis revealed distinct pathways involved in aged female and male skeletal muscle, suggesting the potential for sex-specific therapeutic targets to combat sarcopenia and promote healthy aging.
Article
Neurosciences
Yudai Iwama, Kouichi Takamoto, Daisuke Hibi, Hiroshi Nishimaru, Jumpei Matsumoto, Tsuyoshi Setogawa, Hisao Nishijo
Summary: Discrimination of cues predicting non-nociceptive/nociceptive stimuli is important for predicting pain outcomes. This study found that young females exhibited attenuated placebo effects due to reduced responses in the right dorsolateral prefrontal cortex (dl-PFC) to cues predicting a safe stimulus.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Vasiliy V. Reshetnikov, Polina E. Kisaretova, Natalia P. Bondar
Summary: Research on the molecular causes of stress-associated psychopathologies is crucial for understanding the development mechanisms of depression, generalized anxiety disorder, and posttraumatic stress disorders. This study conducted a meta-analysis of transcriptome changes in mice and human patients, finding the most reliable molecular alterations associated with different durations of stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Brooke N. Dulka, Sydney Trask, Fred J. Helmstetter
Summary: The study found that age and sex have different effects on memory in rats, with aged males showing behavioral deficits in memory retrieval. The markers of UPS function are differently affected by age and sex in various brain regions, indicating circuit-level differences in aging males and females.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jessica Marie Perez, Stefano Berto, Kelly Gleason, Subroto Ghose, Chunfeng Tan, Tae-Kyung Kim, Genevieve Konopka, Carol A. Tamminga
Summary: The study demonstrates unique molecular changes in hippocampal subfields of individuals with schizophrenia, suggesting different biological functions in each subfield which may help identify potential hippocampal-based therapeutic targets for schizophrenia.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
M. L. Shawn Bates, Jay R. Arner, Andre L. Curtis, Rita Valentino, Seema Bhatnagar
Summary: The locus coeruleus-norepinephrine system, which regulates prefrontal cortical networks, shows sex differences in response to stress, mediated by corticotropin-releasing factor (CRF). The effects of CRF on network activity differ qualitatively between male and female rats in terms of dose, region, and timecourse.
Article
Behavioral Sciences
Anand Gururajan
Summary: This study conducted a meta-analysis of chronic stress effects on the prefrontal cortex transcriptome, revealing differentially expressed genes related to synaptic plasticity in stress mice. Resilient mice did not show differential gene expression, while susceptible mice had genes related to oligodendrocytes. These findings provide new insights for the neurobiology and treatment of chronic stress-induced disorders.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2022)
Review
Behavioral Sciences
Chenyi Chen, Yu-Hsin Chen, Yawei Cheng
Summary: This study conducted meta-analyses to investigate the neural mechanisms of clinical empathy. The results showed that healthcare providers had higher scores in empathic concern and perspective-taking, and the activation of anterior mid-cingulate cortex, anterior insula, and ventrolateral prefrontal cortex were consistently identified in clinical empathy.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Malosree Maitra, Haruka Mitsuhashi, Reza Rahimian, Anjali Chawla, Jennie Yang, Laura M. Fiori, Maria Antonietta Davoli, Kelly Perlman, Zahia Aouabed, Deborah C. Mash, Matthew Suderman, Naguib Mechawar, Gustavo Turecki, Corina Nagy
Summary: Major depressive disorder (MDD) is a common psychiatric illness with diverse brain cell types involved in its development. There are significant sexual differences in MDD clinical presentation and molecular basis. In this study, single-nucleus RNA-sequencing data was used to analyze brain cells from male and female donors, revealing similar gene expression patterns but differentially expressed genes (DEGs) in specific cell types between sexes. This research provides insights into the cell type specificity of sex differences in depression.
NATURE COMMUNICATIONS
(2023)
Review
Behavioral Sciences
Simona Raimo, Maria Cropano, Luigi Trojano, Gabriella Santangelo
Summary: The study identified structural changes in gambling disorder (GD) and specific brain activity patterns associated with decision-making and reward processing. Patients with GD showed cortical grey matter thinning in the right ventrolateral and ventromedial prefrontal cortex and hyperactivation in the medial prefrontal cortex and right ventral striatum during decision-making and gain processing compared to healthy subjects. These findings suggest alterations in brain mechanisms related to top-down control and appraisal of gambling-related stimuli in GD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Songphon Kanlayaprasit, Surangrat Thongkorn, Pawinee Panjabud, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana
Summary: Prenatal exposure to BPA disrupts genes in the offspring's prefrontal cortex and may increase the risk of ASD through various mechanisms. The study found that BPA may regulate gene expression through ASD-related transcription factors in a sex-dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Weiping Dai, Shuying Huang, Yuan Luo, Xin Cheng, Pei Xia, Mengqian Yang, Panwu Zhao, Yingying Zhang, Wei-Jye Lin, Xiaojing Ye
Summary: Neuropathic pain induces distinct transcriptomic changes in the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC), with significant differences between female and male mice. These findings provide novel therapeutic targets for chronic pain and its associated affective disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)